{"id":"https://openalex.org/W4401749570","doi":"https://doi.org/10.1109/isbi56570.2024.10635774","title":"AI-Driven Integration of Histological and Genomic Data for Understanding Breast Cancer Survival","display_name":"AI-Driven Integration of Histological and Genomic Data for Understanding Breast Cancer Survival","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401749570","doi":"https://doi.org/10.1109/isbi56570.2024.10635774"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635774","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635774","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092211007","display_name":"Laura Valeria Perez-Herrera","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Valeria Perez-Herrera","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004317311","display_name":"Aurora Sucre","orcid":"https://orcid.org/0000-0002-4078-9275"},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aurora Sucre","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088090513","display_name":"Xabier Calle S\u00e1nchez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xabier Calle Sanchez","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017729193","display_name":"Mar\u00eda Jes\u00fas Garc\u00eda-Gonz\u00e1lez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Jes\u00fas Garc\u00eda-Gonz\u00e1lez","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113342660","display_name":"Guillermo de Celis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillermo de Celis","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077885679","display_name":"Alba Gar\u00edn-Muga","orcid":"https://orcid.org/0000-0002-7160-1191"},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alba Garin-Muga","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091309671","display_name":"Mar\u00eda dM Vivanco","orcid":"https://orcid.org/0000-0002-9540-247X"},"institutions":[{"id":"https://openalex.org/I4210112728","display_name":"CIC bioGUNE","ror":"https://ror.org/02x5c5y60","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210112728"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria dM Vivanco","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Cancer Heterogeneity Lab, CIC bioGUNE,48160,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Cancer Heterogeneity Lab, CIC bioGUNE,48160,Spain","institution_ids":["https://openalex.org/I4210112728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031842436","display_name":"Eduardo Alonso","orcid":"https://orcid.org/0000-0002-3306-695X"},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Alonso","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051099649","display_name":"Karen L\u00f3pez\u2010Linares","orcid":"https://orcid.org/0000-0002-4800-6052"},"institutions":[{"id":"https://openalex.org/I4210092551","display_name":"Vicomtech","ror":"https://ror.org/0023sah13","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092551"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karen L\u00f3pez-Linares","raw_affiliation_strings":["Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basque Research and Technology Alliance (BRTA),Fundación Vicomtech,San Sebastián,Spain,20009","institution_ids":["https://openalex.org/I4210092551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3556,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53139176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6402466893196106},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4672671854496002},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44718867540359497},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3389251232147217},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3308621048927307},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26959067583084106},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23223277926445007}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6402466893196106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4672671854496002},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44718867540359497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3389251232147217},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3308621048927307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26959067583084106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23223277926445007}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635774","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635774","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2005895632","https://openalex.org/W2129112648","https://openalex.org/W2162956417","https://openalex.org/W2585769337","https://openalex.org/W2795989238","https://openalex.org/W2922239620","https://openalex.org/W2954499361","https://openalex.org/W3082123160","https://openalex.org/W3092913069","https://openalex.org/W3128646645","https://openalex.org/W3132836459","https://openalex.org/W3137675974","https://openalex.org/W3175968406","https://openalex.org/W3203898052","https://openalex.org/W4213164367","https://openalex.org/W4280494974","https://openalex.org/W4291021272","https://openalex.org/W4385827562","https://openalex.org/W6637373629"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,51],"(BC)":[2],"poses":[3],"a":[4,18,66,96],"significant":[5,105],"threat":[6],"to":[7,49,130],"public":[8],"health.":[9],"Understanding":[10],"its":[11],"complex":[12],"nature":[13],"using":[14,65],"high-dimensional":[15,135],"data":[16,34],"remains":[17],"challenge.":[19],"Here,":[20],"we":[21,41,54],"explored":[22],"the":[23,36,46,56,126],"predictive":[24,57],"capabilities":[25,127],"of":[26,38,59,80,99,128],"feature":[27],"extraction":[28],"algorithms":[29],"on":[30,45,69],"genomic":[31,75],"and":[32,62,85,109,118],"image":[33,61,89],"within":[35],"context":[37],"BC.":[39],"Firstly,":[40],"trained":[42],"AI":[43,129],"models":[44,76,103],"TCGA":[47],"dataset":[48,72],"identify":[50],"signatures.":[52],"Secondly,":[53],"evaluated":[55],"power":[58],"these":[60],"omics":[63],"features":[64,110,133],"survival":[67,102,139],"framework":[68],"an":[70],"independent":[71],"(METABRIC).":[73],"The":[74,88],"achieved":[77],"AUC":[78],"values":[79],"0.99":[81],"(expression),":[82],"0.78":[83],"(SNPs),":[84],"0.72":[86],"(CNVs).":[87],"segmentation":[90],"model":[91],"distinguished":[92],"histological":[93],"structures":[94],"with":[95],"dice":[97],"score":[98],"0.63.":[100],"Finally,":[101],"showed":[104],"associations":[106],"between":[107],"BC":[108,138],"such":[111],"as":[112],"image-derived":[113],"cell":[114],"stroma":[115],"%":[116],"(p=0.002)":[117],"genetic-derived":[119],"CNV":[120],"status":[121],"(p=4.34\u00d710\u22124).":[122],"Our":[123],"study":[124],"highlights":[125],"capture":[131],"relevant":[132],"in":[134],"data,":[136],"enhancing":[137],"predictions.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}