{"id":"https://openalex.org/W4401749705","doi":"https://doi.org/10.1109/isbi56570.2024.10635626","title":"Deep Learning Enables Reduced Gadolinium Dose for Contrast-Enhanced Blood-Brain Barrier Opening Quantitative Measurement","display_name":"Deep Learning Enables Reduced Gadolinium Dose for Contrast-Enhanced Blood-Brain Barrier Opening Quantitative Measurement","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401749705","doi":"https://doi.org/10.1109/isbi56570.2024.10635626"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635626","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635626","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013269675","display_name":"Pin-Yu Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pin-Yu Lee","raw_affiliation_strings":["Columbia University,Department of Biomedical Engineering,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Department of Biomedical Engineering,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108749740","display_name":"S Mehta","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubh P. Mehta","raw_affiliation_strings":["Columbia University,Department of Biomedical Engineering,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Department of Biomedical Engineering,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101580492","display_name":"Anurag Sharma","orcid":"https://orcid.org/0000-0003-0926-1699"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anurag Sharma","raw_affiliation_strings":["Columbia University,Department of Biomedical Engineering,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Department of Biomedical Engineering,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067008386","display_name":"Hongjian Wei","orcid":"https://orcid.org/0000-0001-8841-5419"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Jian Wei","raw_affiliation_strings":["Columbia University Irving Medical Center,Department of Radiation Oncology,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center,Department of Radiation Oncology,New York,NY,USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067166873","display_name":"Antonios N. Pouliopoulos","orcid":"https://orcid.org/0000-0002-8891-1495"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonios N. Pouliopoulos","raw_affiliation_strings":["School of Biomedical Engineering &amp; Imaging Sciences, King&#x2019;s College London,London,UK"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering &amp; Imaging Sciences, King&#x2019;s College London,London,UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552790","display_name":"Yanting Yang","orcid":"https://orcid.org/0000-0001-6076-6436"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanting Yang","raw_affiliation_strings":["Columbia University,Department of Biomedical Engineering,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Department of Biomedical Engineering,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006526154","display_name":"Chenghao Zhang","orcid":"https://orcid.org/0000-0002-5252-0046"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenghao Zhang","raw_affiliation_strings":["Columbia University,Department of Biomedical Engineering,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Department of Biomedical Engineering,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090489079","display_name":"Andrew F. Laine","orcid":"https://orcid.org/0000-0003-3797-0628"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew F. Laine","raw_affiliation_strings":["Columbia University,Departments of Biomedical Engineering and Radiology,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Departments of Biomedical Engineering and Radiology,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000454252","display_name":"Elisa E. Konofagou","orcid":"https://orcid.org/0000-0002-9636-7936"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa E. Konofagou","raw_affiliation_strings":["Columbia University,Departments of Biomedical Engineering and Radiology,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University,Departments of Biomedical Engineering and Radiology,New York,NY,USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028180281","display_name":"Cheng\u2013Chia Wu","orcid":"https://orcid.org/0000-0002-5908-0143"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng-Chia Wu","raw_affiliation_strings":["Columbia University Irving Medical Center,Department of Radiation Oncology,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center,Department of Radiation Oncology,New York,NY,USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043650123","display_name":"Jia Guo","orcid":"https://orcid.org/0000-0003-4803-0279"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Guo","raw_affiliation_strings":["Columbia University Irving Medical Center,Department of Psychiatry,New York,NY,USA"],"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center,Department of Psychiatry,New York,NY,USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5013269675"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":1.2886,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.80449631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium","display_name":"Gadolinium","score":0.7962161302566528},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.7144714593887329},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.5465372800827026},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3858920931816101},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.37088292837142944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34921860694885254},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2921909987926483},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21209141612052917},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14573746919631958},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.09486398100852966}],"concepts":[{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.7962161302566528},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7144714593887329},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5465372800827026},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3858920931816101},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37088292837142944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34921860694885254},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2921909987926483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21209141612052917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14573746919631958},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09486398100852966},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635626","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635626","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1976910291","https://openalex.org/W2007906038","https://openalex.org/W2028062716","https://openalex.org/W2101099825","https://openalex.org/W2109775563","https://openalex.org/W2117538553","https://openalex.org/W2138053088","https://openalex.org/W2150489367","https://openalex.org/W2168127946","https://openalex.org/W2419203739","https://openalex.org/W2751129484","https://openalex.org/W2783216098","https://openalex.org/W2789565832","https://openalex.org/W2796476116","https://openalex.org/W2946993208","https://openalex.org/W3111040627","https://openalex.org/W4241074797","https://openalex.org/W6631190155"],"related_works":["https://openalex.org/W4385543984","https://openalex.org/W2751885695","https://openalex.org/W4301391107","https://openalex.org/W2328364605","https://openalex.org/W2964601861","https://openalex.org/W3022866692","https://openalex.org/W3040057392","https://openalex.org/W2054514606","https://openalex.org/W2065385185","https://openalex.org/W1580543246"],"abstract_inverted_index":{"Focused":[0],"ultrasound":[1],"(FUS)":[2],"has":[3],"the":[4,8,28,48,88,99,105,143],"capability":[5],"to":[6,23,46,59],"open":[7],"blood-brain":[9],"barrier":[10],"(BBB),":[11],"and":[12,66],"magnetic":[13],"resonance":[14],"imaging":[15],"(MRI)":[16],"with":[17,73],"contrast":[18,33,75],"agents":[19,34],"can":[20],"be":[21],"employed":[22],"detect":[24],"this":[25,40,80],"opening.":[26],"However,":[27],"repeated":[29],"use":[30],"of":[31,125,142],"gadolinium-based":[32],"(GBCAs)":[35],"raises":[36],"safety":[37],"concerns.":[38],"In":[39],"study,":[41],"we":[42,103],"propose":[43],"an":[44],"approach":[45],"modeling":[47],"volume":[49],"transfer":[50],"constant":[51],"(K<sup":[52],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[53,63],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">trans</sup>)":[54],"through":[55],"deep":[56,115],"learning,":[57],"aiming":[58],"reconstruct":[60],"artificial":[61],"K<sup":[62],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">trans</sup>":[64],"maps":[65],"enhance":[67],"intensity":[68],"using":[69,82],"T1-weighted":[70],"MRI":[71],"scans":[72],"low-dose":[74],"agents.":[76],"We":[77],"successfully":[78],"validated":[79],"concept":[81],"a":[83,109,119],"state-of-the-art":[84],"algorithm":[85],"known":[86],"as":[87],"temporal":[89],"network,":[90],"which":[91],"focuses":[92],"on":[93,129],"extracting":[94],"time":[95],"domain":[96],"features":[97],"at":[98],"voxel":[100],"level.":[101],"Subsequently,":[102],"introduced":[104],"Spatiotemporal":[106],"Network":[107],"(ST-Net),":[108],"spatiotemporal":[110],"convolutional":[111],"neural":[112],"network":[113],"(CNN)-based":[114],"learning":[116],"architecture,":[117],"incorporating":[118],"three-dimensional":[120],"CNN":[121],"encoder.":[122],"The":[123],"performance":[124],"ST-Net":[126],"was":[127],"evaluated":[128],"nine":[130],"separate":[131],"testing":[132],"datasets,":[133],"each":[134],"representing":[135],"FUS-induced":[136],"BBB":[137],"opening":[138],"in":[139],"different":[140],"regions":[141],"brain.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
