{"id":"https://openalex.org/W4401795030","doi":"https://doi.org/10.1109/isbi56570.2024.10635442","title":"Late Life Depression Automated Detection by Means of Advanced Diffusion Tensor Imaging Segmentation and Artificial Intelligence","display_name":"Late Life Depression Automated Detection by Means of Advanced Diffusion Tensor Imaging Segmentation and Artificial Intelligence","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401795030","doi":"https://doi.org/10.1109/isbi56570.2024.10635442"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635442","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635442","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065465237","display_name":"Kostas Siarkos","orcid":"https://orcid.org/0000-0002-3366-2989"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Kostas Siarkos","raw_affiliation_strings":["National and Kapodistrian University of Athens,Division of Geriatric Psychiatry,First Department of Psychiatry,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"National and Kapodistrian University of Athens,Division of Geriatric Psychiatry,First Department of Psychiatry,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033299914","display_name":"Christos D. Katsis","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos D. Katsis","raw_affiliation_strings":["University of Ioannina,Department of Informatics and Telecommunications,Kostakioi, Arta,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Department of Informatics and Telecommunications,Kostakioi, Arta,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020230795","display_name":"Georgios Antonopoulos","orcid":"https://orcid.org/0000-0002-1274-5160"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georgios Antonopoulos","raw_affiliation_strings":["Heinrich Heine University Düsseldorf,Institute of Systems Neuroscience,Düsseldorf,Germany"],"affiliations":[{"raw_affiliation_string":"Heinrich Heine University Düsseldorf,Institute of Systems Neuroscience,Düsseldorf,Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081498241","display_name":"Efstratios Karavasilis","orcid":"https://orcid.org/0000-0002-7291-2231"},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Efstratios Karavasilis","raw_affiliation_strings":["Democritus University of Thrace,Medical School,Alexandroupolis,Greece"],"affiliations":[{"raw_affiliation_string":"Democritus University of Thrace,Medical School,Alexandroupolis,Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086712742","display_name":"Georgios Velonakis","orcid":"https://orcid.org/0000-0002-0050-284X"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Velonakis","raw_affiliation_strings":["Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Radiology,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040542387","display_name":"Charalabos Papageorgiou","orcid":"https://orcid.org/0000-0001-7635-1956"},"institutions":[{"id":"https://openalex.org/I4210115397","display_name":"University Mental Health Research Institute","ror":"https://ror.org/02d439m40","country_code":"GR","type":"education","lineage":["https://openalex.org/I4210115397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalabos Papageorgiou","raw_affiliation_strings":["University Mental Health, Neurosciences and Precision Medicine Research Institute \"Costas Stefanis\",Athens,Greece"],"affiliations":[{"raw_affiliation_string":"University Mental Health, Neurosciences and Precision Medicine Research Institute \"Costas Stefanis\",Athens,Greece","institution_ids":["https://openalex.org/I4210115397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042620146","display_name":"Nikolaos Smyrnis","orcid":"https://orcid.org/0000-0002-1461-6151"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Smyrnis","raw_affiliation_strings":["Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Psychiatry,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Psychiatry,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046145965","display_name":"Nikolaos Kelekis","orcid":"https://orcid.org/0000-0002-8958-4668"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Kelekis","raw_affiliation_strings":["Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Radiology,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens,Second Department of Radiology,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031438015","display_name":"Euripidis Glavas","orcid":"https://orcid.org/0000-0002-5604-3507"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Euripidis Glavas","raw_affiliation_strings":["University of Ioannina,Department of Informatics and Telecommunications,Kostakioi, Arta,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Department of Informatics and Telecommunications,Kostakioi, Arta,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087578031","display_name":"Antonios Politis","orcid":"https://orcid.org/0000-0003-0261-7517"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonios Politis","raw_affiliation_strings":["National and Kapodistrian University of Athens,Division of Geriatric Psychiatry,First Department of Psychiatry,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"National and Kapodistrian University of Athens,Division of Geriatric Psychiatry,First Department of Psychiatry,Athens,Greece","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5065465237"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22893915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6023731827735901},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5447030067443848},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5446502566337585},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5433313846588135},{"id":"https://openalex.org/keywords/artificial-life","display_name":"Artificial life","score":0.4805094003677368},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.4333745837211609},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4227627217769623},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.16131865978240967},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12091413140296936},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.07950213551521301}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6023731827735901},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5447030067443848},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5446502566337585},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5433313846588135},{"id":"https://openalex.org/C19273510","wikidata":"https://www.wikidata.org/wiki/Q263847","display_name":"Artificial life","level":2,"score":0.4805094003677368},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4333745837211609},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4227627217769623},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.16131865978240967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12091413140296936},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07950213551521301},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635442","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635442","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1594031697","https://openalex.org/W1847168837","https://openalex.org/W1998049664","https://openalex.org/W2076143792","https://openalex.org/W2089899747","https://openalex.org/W2106617446","https://openalex.org/W2117684832","https://openalex.org/W2127610265","https://openalex.org/W2145073242","https://openalex.org/W2148143831","https://openalex.org/W2518294556","https://openalex.org/W3036341959","https://openalex.org/W3099245566","https://openalex.org/W4220722125","https://openalex.org/W4388297464","https://openalex.org/W4390009423","https://openalex.org/W6601913397","https://openalex.org/W6681651645"],"related_works":["https://openalex.org/W2537246788","https://openalex.org/W4214553788","https://openalex.org/W2091786736","https://openalex.org/W2363328217","https://openalex.org/W2145162363","https://openalex.org/W2899801428","https://openalex.org/W3088448422","https://openalex.org/W1768769760","https://openalex.org/W2413360119","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Although":[0],"late-life":[1],"depression":[2],"(LLD)":[3],"is":[4,22],"a":[5,51],"common":[6],"mental":[7],"health":[8],"problem":[9],"in":[10,43],"seniors":[11],"and":[12,24,64,70,83,106,110,119,127],"linked":[13],"with":[14],"dementia,":[15],"its":[16],"diagnosis":[17],"remains":[18],"challenging.":[19],"Early":[20],"treatment":[21],"vital":[23],"depending":[25],"on":[26,58],"accurate":[27],"diagnosis.":[28],"Brain":[29],"white":[30],"matter":[31],"(WM)":[32],"changes":[33],"revealed":[34],"by":[35,99],"Diffusion":[36],"Tensor":[37],"Imaging":[38],"(DTI)":[39],"have":[40],"been":[41],"identified":[42],"LLD,":[44],"yet":[45],"results":[46,141],"exhibit":[47],"variability.":[48],"We":[49],"propose":[50],"methodology":[52],"for":[53,80],"LLD":[54,126],"automated":[55],"classification":[56],"based":[57],"an":[59],"advanced":[60],"DTI":[61,87],"segmentation":[62],"framework":[63],"artificial":[65],"intelligence":[66],"(AI).":[67],"Twenty-six":[68],"patients":[69],"12":[71],"healthy":[72],"individuals":[73],"(HC)":[74],"aged":[75],">":[76],"55":[77],"years,":[78],"matched":[79],"age,":[81],"education,":[82],"MMSE":[84],"participated.":[85],"Five":[86],"measures":[88],"were":[89],"calculated":[90],"within":[91],"146":[92],"WM":[93],"segments.":[94],"A":[95],"dataset":[96],"was":[97,137],"constructed":[98],"the":[100,112],"extracted":[101],"features":[102],"from":[103],"each":[104],"subject":[105],"used":[107],"to":[108,123,130],"train":[109],"test":[111],"AdaBoost,":[113],"Multilayer":[114],"Perceptron":[115],"Artificial":[116],"Neural":[117],"Network":[118],"Random":[120],"Tree":[121],"classifiers":[122],"automatically":[124],"detect":[125],"HC.":[128],"Due":[129],"class":[131],"imbalance,":[132],"Synthetic":[133],"Minority":[134],"Over-sampling":[135],"Technique":[136],"applied.":[138],"Our":[139],"initial":[140],"encourage":[142],"further":[143],"investigation.":[144]},"counts_by_year":[],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}