{"id":"https://openalex.org/W4386362643","doi":"https://doi.org/10.1109/isbi53787.2023.10230486","title":"GLFA-NET: A Hybrid Network for Mr-To-Ct Synthesis Via Global and Local Feature Aggregation","display_name":"GLFA-NET: A Hybrid Network for Mr-To-Ct Synthesis Via Global and Local Feature Aggregation","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4386362643","doi":"https://doi.org/10.1109/isbi53787.2023.10230486"},"language":"en","primary_location":{"id":"doi:10.1109/isbi53787.2023.10230486","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi53787.2023.10230486","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101912002","display_name":"Zeli Chen","orcid":"https://orcid.org/0009-0006-8976-1771"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zeli Chen","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063253388","display_name":"Chuanpu Li","orcid":null},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanpu Li","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068119300","display_name":"Kaiyi Zheng","orcid":"https://orcid.org/0009-0003-0462-9949"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiyi Zheng","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430664","display_name":"Yiwen Zhang","orcid":"https://orcid.org/0000-0002-4883-0607"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Zhang","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085066668","display_name":"Yuankui Wu","orcid":"https://orcid.org/0000-0002-5140-4860"},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuankui Wu","raw_affiliation_strings":["Southern Medical University,Nanfang Hospital,Department of Medical Imaging Center,Guangzhou,China,510515"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,Nanfang Hospital,Department of Medical Imaging Center,Guangzhou,China,510515","institution_ids":["https://openalex.org/I58200834","https://openalex.org/I4210103346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100772585","display_name":"Qianjin Feng","orcid":"https://orcid.org/0000-0001-8647-0596"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianjin Feng","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070483964","display_name":"Liming Zhong","orcid":"https://orcid.org/0000-0002-0048-7838"},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Zhong","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834","https://openalex.org/I4210103346"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044127793","display_name":"Wei Yang","orcid":"https://orcid.org/0000-0002-2161-3231"},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["Southern Medical University,School of Biomedical Engineering,Guangzhou,China","School of Biomedical Engineering, Southern Medical University, Guangzhou, China","Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China","Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Southern Medical University,School of Biomedical Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Biomedical Engineering, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834","https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101912002"],"corresponding_institution_ids":["https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":0.6993,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75685015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11105","display_name":"Advanced Image Processing Techniques","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7181029319763184},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5605556964874268},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.507072925567627},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4855663478374481},{"id":"https://openalex.org/keywords/residual","display_name":"Residual","score":0.47553205490112305},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.46959176659584045},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.46162158250808716},{"id":"https://openalex.org/keywords/discriminator","display_name":"Discriminator","score":0.4243607521057129},{"id":"https://openalex.org/keywords/wavelet","display_name":"Wavelet","score":0.41083014011383057},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2904474139213562},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12902984023094177},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.09178587794303894}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7181029319763184},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5605556964874268},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.507072925567627},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4855663478374481},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.47553205490112305},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.46959176659584045},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.46162158250808716},{"id":"https://openalex.org/C2779803651","wikidata":"https://www.wikidata.org/wiki/Q5282088","display_name":"Discriminator","level":3,"score":0.4243607521057129},{"id":"https://openalex.org/C47432892","wikidata":"https://www.wikidata.org/wiki/Q831390","display_name":"Wavelet","level":2,"score":0.41083014011383057},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2904474139213562},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12902984023094177},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.09178587794303894},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi53787.2023.10230486","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi53787.2023.10230486","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.5799999833106995,"display_name":"Reduced inequalities"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1859655790","https://openalex.org/W1901129140","https://openalex.org/W2038406583","https://openalex.org/W2567079332","https://openalex.org/W2783666954","https://openalex.org/W2962793481","https://openalex.org/W2963073614","https://openalex.org/W2963152299","https://openalex.org/W2963176524","https://openalex.org/W2964261768","https://openalex.org/W3006334245","https://openalex.org/W3094502228","https://openalex.org/W3127751679","https://openalex.org/W3150890754","https://openalex.org/W3176466780","https://openalex.org/W4221163766","https://openalex.org/W4312358791","https://openalex.org/W6784333009","https://openalex.org/W6790275670"],"related_works":["https://openalex.org/W4293202849","https://openalex.org/W1980965563","https://openalex.org/W1489300767","https://openalex.org/W4380714744","https://openalex.org/W2387995142","https://openalex.org/W4319453655","https://openalex.org/W2089959425","https://openalex.org/W2964074194","https://openalex.org/W2057775761","https://openalex.org/W2904326725"],"abstract_inverted_index":{"Synthesis":[0],"of":[1,81,145,166,180,197,202,208,227],"Computed":[2],"Tomography":[3],"(CT)":[4],"images":[5,10],"from":[6,34,99,121],"Magnetic":[7],"Resonance":[8],"(MR)":[9],"is":[11],"clinical":[12],"significance":[13],"for":[14,90],"MR-only":[15],"treatment":[16],"planning":[17],"to":[18,41,113,140,160],"eliminate":[19],"the":[20,35,70,79,115,122,133,142,162,167,220],"co-registration":[21],"errors":[22],"between":[23],"MR":[24,52],"and":[25,44,73,95,101,124,137,147,149,184,206,229,231],"CT":[26,215],"images.":[27,53,186],"Existing":[28],"convolutional":[29],"neural":[30],"network-based":[31],"methods,":[32],"suffering":[33],"inherent":[36],"local":[37,75,96,134],"inductive":[38],"biases,":[39],"struggle":[40],"distinguish":[42],"bone":[43,146,228],"air":[45,148,230],"which":[46],"show":[47,188,218],"low":[48],"signals":[49],"in":[50],"conventional":[51],"ViT-based":[54],"methods":[55],"can":[56],"learn":[57],"long-range":[58],"contextual":[59],"information":[60,165],"by":[61,69],"a":[62,87,108,126,156,175],"global":[63,94,109,117,138],"self-attention":[64],"mechanism":[65],"but":[66],"are":[67],"limited":[68],"quadratic":[71],"complexity":[72],"generating":[74],"detailed":[76,135,164],"structures.":[77],"Combining":[78],"merits":[80],"these":[82],"two":[83],"architectures,":[84],"we":[85,106,154],"propose":[86],"hybrid":[88],"network":[89],"MR-to-CT":[91],"synthesis":[92,143],"via":[93],"feature":[97],"aggregation":[98],"Transformer":[100],"CNN,":[102],"named":[103],"GLFA-NET.":[104],"Specifically,":[105],"add":[107],"patch":[110],"embedding":[111],"branch":[112],"supplement":[114],"patch-based":[116],"representative":[118],"features":[119,136,139],"directly":[120],"image":[123],"design":[125],"residual":[127],"dilated":[128],"swin":[129],"transformer":[130],"block":[131],"aggregating":[132],"improve":[141],"performance":[144,194],"reduce":[150],"computational":[151],"overhead.":[152],"Furthermore,":[153],"adopt":[155],"wavelet":[157],"PatchGAN":[158],"discriminator":[159],"enhance":[161],"high-frequency":[163],"synthetic":[168,214],"CT.":[169],"Our":[170],"GLFA-NET":[171,191,222],"was":[172],"implemented":[173],"on":[174],"dataset":[176],"with":[177,195],"154":[178],"pairs":[179],"3D":[181],"MR-CT":[182],"head":[183],"neck":[185],"Experiments":[187],"that":[189,219],"our":[190],"achieves":[192,224],"impressive":[193],"MAE":[196],"71.12":[198],"\u00b1":[199,204,210],"10.87,":[200],"SSIM":[201],"0.771":[203],"0.028,":[205],"PSNR":[207],"28.91":[209],"1.33.":[211],"The":[212],"visual":[213],"results":[216],"also":[217],"proposed":[221],"method":[223],"better":[225],"discrimination":[226],"higher":[232],"structural":[233],"similarity":[234],"than":[235],"other":[236],"state-of-the-art":[237],"methods.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}