{"id":"https://openalex.org/W4386362745","doi":"https://doi.org/10.1109/isbi53787.2023.10230362","title":"Scale-Aware Multi-Instance Learning for Early Prognosis of Subjects at Risk of Developing Hepatocellular Carcinoma","display_name":"Scale-Aware Multi-Instance Learning for Early Prognosis of Subjects at Risk of Developing Hepatocellular Carcinoma","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4386362745","doi":"https://doi.org/10.1109/isbi53787.2023.10230362"},"language":"en","primary_location":{"id":"doi:10.1109/isbi53787.2023.10230362","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi53787.2023.10230362","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055502200","display_name":"Ananya Jana","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ananya Jana","raw_affiliation_strings":["Rutgers University,Department of Computer Science","Department of Computer Science, Rutgers University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University,Department of Computer Science","institution_ids":["https://openalex.org/I4210096112"]},{"raw_affiliation_string":"Department of Computer Science, Rutgers University","institution_ids":["https://openalex.org/I4210096112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047957264","display_name":"Ramanathan Arunachalam","orcid":"https://orcid.org/0000-0001-8934-0981"},"institutions":[{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ramanathan Arunachalam","raw_affiliation_strings":["Rutgers University,Department of Computer Science","Department of Computer Science, Rutgers University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University,Department of Computer Science","institution_ids":["https://openalex.org/I4210096112"]},{"raw_affiliation_string":"Department of Computer Science, Rutgers University","institution_ids":["https://openalex.org/I4210096112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081747918","display_name":"Carlos D. Minacapelli","orcid":"https://orcid.org/0000-0001-7295-0249"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I2802203029","display_name":"Johnson University","ror":"https://ror.org/04dpnfr42","country_code":"US","type":"education","lineage":["https://openalex.org/I2802203029"]},{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Carlos D. Minacapelli","raw_affiliation_strings":["Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","institution_ids":["https://openalex.org/I2802203029"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I2802203029","https://openalex.org/I4210096112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021808214","display_name":"Kaitlyn Catalano","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I2802203029","display_name":"Johnson University","ror":"https://ror.org/04dpnfr42","country_code":"US","type":"education","lineage":["https://openalex.org/I2802203029"]},{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Catalano","raw_affiliation_strings":["Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","institution_ids":["https://openalex.org/I2802203029"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I2802203029","https://openalex.org/I4210096112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063353314","display_name":"Carlos Catalano","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I2802203029","display_name":"Johnson University","ror":"https://ror.org/04dpnfr42","country_code":"US","type":"education","lineage":["https://openalex.org/I2802203029"]},{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Carlos Catalano","raw_affiliation_strings":["Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","institution_ids":["https://openalex.org/I2802203029"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I2802203029","https://openalex.org/I4210096112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065814121","display_name":"Vinod K. Rustgi","orcid":"https://orcid.org/0000-0002-4105-5783"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I2802203029","display_name":"Johnson University","ror":"https://ror.org/04dpnfr42","country_code":"US","type":"education","lineage":["https://openalex.org/I2802203029"]},{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Vinod Rustgi","raw_affiliation_strings":["Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Robert Wood Johnson Medical School,Division of Gastroenterology and Hepatology","institution_ids":["https://openalex.org/I2802203029"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I2802203029","https://openalex.org/I4210096112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064437234","display_name":"Dimitris Metaxas","orcid":"https://orcid.org/0000-0001-7142-7640"},"institutions":[{"id":"https://openalex.org/I4210096112","display_name":"Rutgers Sexual and Reproductive Health and Rights","ror":"https://ror.org/00rcvgx40","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210096112"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dimitris Metaxas","raw_affiliation_strings":["Rutgers University,Department of Computer Science","Department of Computer Science, Rutgers University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University,Department of Computer Science","institution_ids":["https://openalex.org/I4210096112"]},{"raw_affiliation_string":"Department of Computer Science, Rutgers University","institution_ids":["https://openalex.org/I4210096112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.7087241411209106},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6707159280776978},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.6231135129928589},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4392319321632385},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27597519755363464},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.223857581615448}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7087241411209106},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6707159280776978},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.6231135129928589},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4392319321632385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27597519755363464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.223857581615448},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi53787.2023.10230362","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi53787.2023.10230362","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.47999998927116394}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2012975578","https://openalex.org/W2194775991","https://openalex.org/W2526009326","https://openalex.org/W2752675670","https://openalex.org/W2785934082","https://openalex.org/W2898568606","https://openalex.org/W2944233989","https://openalex.org/W2997512706","https://openalex.org/W3116042121","https://openalex.org/W3146908429","https://openalex.org/W3165099967","https://openalex.org/W3204559658","https://openalex.org/W4287755086","https://openalex.org/W4309233581","https://openalex.org/W6639824700","https://openalex.org/W6747701563","https://openalex.org/W6758047254","https://openalex.org/W6779992872","https://openalex.org/W6800214786"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W2404951810"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,94],"a":[4,63,79,117,125,145],"type":[5],"of":[6,50,100,108,124,127,141,147],"primary":[7],"liver":[8],"cancer":[9],"which":[10],"can":[11],"potentially":[12],"lead":[13],"to":[14,45,77,84,120,130],"the":[15,22,25,75,96,112,122,139],"subject\u2019s":[16],"death.":[17],"The":[18],"subject":[19,129],"usually":[20],"experiences":[21],"symptoms":[23],"when":[24],"HCC":[26,52,102,128,132],"has":[27],"grown":[28,105],"significantly":[29],"and":[30,37],"needs":[31],"advanced":[32],"treatment":[33],"such":[34],"as":[35],"surgery":[36],"extensive":[38],"chemotherapy.":[39],"Thus":[40],"it":[41],"would":[42],"be":[43],"beneficial":[44],"classify":[46,85],"subjects":[47,87,97],"at":[48,98],"risk":[49,99],"developing":[51,101],"based":[53,82,88],"on":[54,89,111,144],"non-invasive":[55],"CT":[56,90,113],"scans.":[57,114],"In":[58],"this":[59],"work,":[60],"we":[61,73],"propose":[62,78,116],"novel":[64],"method":[65,83,119,143],"for":[66],"pre-cancer":[67,86],"stage":[68],"classification.":[69],"To":[70],"our":[71,142],"knowledge,":[72],"are":[74],"first":[76],"Deep":[80],"Learning":[81],"images.":[91],"Our":[92],"hypothesis":[93],"that":[95],"may":[103],"have":[104],"different":[106],"scales/levels":[107],"visual":[109],"cues":[110],"We":[115,137],"scale-aware":[118],"facilitate":[121],"prediction":[123],"free":[126],"develop":[131],"without":[133],"additional":[134],"annotation":[135],"cost.":[136],"show":[138],"efficacy":[140],"dataset":[146],"60":[148],"subjects.1.":[149]},"counts_by_year":[],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
