{"id":"https://openalex.org/W4225014798","doi":"https://doi.org/10.1109/isbi52829.2022.9761498","title":"Spatial Analysis For Histopathology: A Statistical Approach","display_name":"Spatial Analysis For Histopathology: A Statistical Approach","publication_year":2022,"publication_date":"2022-03-28","ids":{"openalex":"https://openalex.org/W4225014798","doi":"https://doi.org/10.1109/isbi52829.2022.9761498"},"language":"en","primary_location":{"id":"doi:10.1109/isbi52829.2022.9761498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761498","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076283372","display_name":"Suvadip Mukherjee","orcid":"https://orcid.org/0000-0002-2842-6527"},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Suvadip Mukherjee","raw_affiliation_strings":["CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France"],"affiliations":[{"raw_affiliation_string":"CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112992372","display_name":"Vannary Meas\u2010Yedid","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vannary Meas-Yedid","raw_affiliation_strings":["CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France"],"affiliations":[{"raw_affiliation_string":"CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069579990","display_name":"Marc Bokobza","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Bokobza","raw_affiliation_strings":["CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France"],"affiliations":[{"raw_affiliation_string":"CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028273553","display_name":"Thibault Lagache","orcid":"https://orcid.org/0000-0002-7033-4677"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thibault Lagache","raw_affiliation_strings":["CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France"],"affiliations":[{"raw_affiliation_string":"CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047041645","display_name":"Alexandre Corthay","orcid":"https://orcid.org/0000-0001-9519-5725"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Alexandre Corthay","raw_affiliation_strings":["Oslo University Hospital,Department of Pathology,Oslo,Norway","Department of Pathology, Oslo University Hospital, Oslo, Norway"],"affiliations":[{"raw_affiliation_string":"Oslo University Hospital,Department of Pathology,Oslo,Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Pathology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003562216","display_name":"Jean\u2010Christophe Olivo\u2010Mar\u00edn","orcid":"https://orcid.org/0000-0001-6796-0696"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"funder","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Christophe Olivo-Marin","raw_affiliation_strings":["CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France"],"affiliations":[{"raw_affiliation_string":"CNRS-UMR3691, & Université de Paris,BIA Unit, Institut Pasteur, Paris,France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076283372"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"],"apc_list":null,"apc_paid":null,"fwci":0.4158,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55338289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10770","display_name":"Soil Geostatistics and Mapping","score":0.9225999712944031,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5816477537155151},{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.5586099028587341},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"Statistical analysis","score":0.4165474772453308},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3387930989265442},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2560794949531555},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21506208181381226},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11833277344703674},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08901935815811157}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5816477537155151},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5586099028587341},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.4165474772453308},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3387930989265442},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2560794949531555},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21506208181381226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11833277344703674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08901935815811157}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi52829.2022.9761498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761498","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:pasteur-03699893v1","is_oa":false,"landing_page_url":"https://pasteur.hal.science/pasteur-03699893","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI), Mar 2022, Kolkata, India. pp.1-5, ⟨10.1109/ISBI52829.2022.9761498⟩","raw_type":"Conference papers"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322364","display_name":"Labex","ror":"https://ror.org/01cvsyf94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1501069996","https://openalex.org/W2027181118","https://openalex.org/W2032101051","https://openalex.org/W2040414046","https://openalex.org/W2398921440","https://openalex.org/W2766865858","https://openalex.org/W2805496163","https://openalex.org/W2915640296","https://openalex.org/W2953940735","https://openalex.org/W3016488365","https://openalex.org/W3036021759","https://openalex.org/W3093154039","https://openalex.org/W3095472830","https://openalex.org/W3099404130","https://openalex.org/W3103046698","https://openalex.org/W3158518460","https://openalex.org/W3211842141","https://openalex.org/W4214806317","https://openalex.org/W6759488916","https://openalex.org/W6795265474"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3039419443","https://openalex.org/W4386772532","https://openalex.org/W4393212117","https://openalex.org/W2115661411","https://openalex.org/W2399391471","https://openalex.org/W2400254106","https://openalex.org/W2970729894","https://openalex.org/W4381996710"],"abstract_inverted_index":{"A":[0],"pattern":[1],"analysis":[2],"approach":[3],"is":[4],"proposed":[5,32],"to":[6,38,92,101],"model":[7],"spatial":[8,69],"interaction":[9],"between":[10],"the":[11,15,21,31,44,58,68,98],"immune":[12,72,102],"cells":[13,19,73],"and":[14,53,97],"islets":[16],"of":[17,43,60,71],"cancer":[18,78],"within":[20],"tumor":[22,45],"microenvironment.":[23],"Embedded":[24],"in":[25,63,87],"a":[26,35],"statistical":[27,81],"null":[28],"hypothesis":[29],"paradigm,":[30],"solution":[33],"provides":[34],"novel":[36],"mechanism":[37],"extract":[39],"quantitative,":[40],"system-level":[41],"snap-shot":[42],"microenvironment":[46],"during":[47,77],"immunotherapy.":[48],"Experimental":[49],"results":[50],"on":[51],"synthetic":[52],"real":[54],"histopathological":[55],"data":[56],"suggest":[57],"potential":[59],"our":[61],"technique":[62],"mining":[64],"robust":[65],"information":[66],"from":[67],"distribution":[70],"at":[74],"different":[75],"time-points":[76],"treatment.":[79],"This":[80],"framework":[82],"could":[83],"be":[84],"potentially":[85],"adopted":[86],"future":[88],"large-scale":[89],"experimental":[90],"studies":[91],"objectively":[93],"monitor":[94],"disease":[95],"progression":[96],"patient\u2019s":[99],"response":[100],"therapy.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}