{"id":"https://openalex.org/W4224987873","doi":"https://doi.org/10.1109/isbi52829.2022.9761449","title":"Interpretable Graph Convolutional Network Of Multi-Modality Brain Imaging For Alzheimer\u2019s Disease Diagnosis","display_name":"Interpretable Graph Convolutional Network Of Multi-Modality Brain Imaging For Alzheimer\u2019s Disease Diagnosis","publication_year":2022,"publication_date":"2022-03-28","ids":{"openalex":"https://openalex.org/W4224987873","doi":"https://doi.org/10.1109/isbi52829.2022.9761449"},"language":"en","primary_location":{"id":"doi:10.1109/isbi52829.2022.9761449","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761449","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2204.13188","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000655873","display_name":"Houliang Zhou","orcid":"https://orcid.org/0000-0002-5793-3042"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Houliang Zhou","raw_affiliation_strings":["Lehigh University,Department of Computer Science and Engineering,PA,USA","Department of Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Department of Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071709543","display_name":"Lifang He","orcid":"https://orcid.org/0000-0001-7810-9071"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lifang He","raw_affiliation_strings":["Lehigh University,Department of Computer Science and Engineering,PA,USA","Department of Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Department of Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433744","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0003-4087-6544"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Lehigh University,Department of Bioengineering,PA,USA","Department of Bioengineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Department of Bioengineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Department of Bioengineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["University of Pennsylvania,Department of Biostatistics, Epidemiology and Informatics,PA,USA","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, PA, USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Department of Biostatistics, Epidemiology and Informatics,PA,USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060883710","display_name":"Brian Chen","orcid":"https://orcid.org/0000-0001-6384-1673"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Chen","raw_affiliation_strings":["Lehigh University,Department of Computer Science and Engineering,PA,USA","Department of Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Department of Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000655873"],"corresponding_institution_ids":["https://openalex.org/I186143895"],"apc_list":null,"apc_paid":null,"fwci":5.8177,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.98532864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7145410776138306},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.673701286315918},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.6298542022705078},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.570740282535553},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5275471210479736},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.5203187465667725},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4817257225513458},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42950648069381714},{"id":"https://openalex.org/keywords/modalities","display_name":"Modalities","score":0.42772117257118225},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4192469120025635},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3704315423965454},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24166584014892578},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.22113245725631714},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.17299029231071472},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14628508687019348}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7145410776138306},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.673701286315918},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6298542022705078},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.570740282535553},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5275471210479736},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5203187465667725},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4817257225513458},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42950648069381714},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.42772117257118225},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4192469120025635},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3704315423965454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24166584014892578},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22113245725631714},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17299029231071472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14628508687019348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi52829.2022.9761449","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761449","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:2204.13188","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2204.13188","pdf_url":"https://arxiv.org/pdf/2204.13188","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2204.13188","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2204.13188","pdf_url":"https://arxiv.org/pdf/2204.13188","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7799999713897705}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2005821483","https://openalex.org/W2058046532","https://openalex.org/W2108878896","https://openalex.org/W2119848633","https://openalex.org/W2155513557","https://openalex.org/W2157751286","https://openalex.org/W2606780347","https://openalex.org/W2788919350","https://openalex.org/W2964015378","https://openalex.org/W2964113829","https://openalex.org/W2972317931","https://openalex.org/W2979481854","https://openalex.org/W2981153408","https://openalex.org/W3103717137","https://openalex.org/W3179895881","https://openalex.org/W3199008037","https://openalex.org/W4287642280","https://openalex.org/W6683252356","https://openalex.org/W6685350579","https://openalex.org/W6726873649","https://openalex.org/W6736685754","https://openalex.org/W6748524405","https://openalex.org/W6767288045","https://openalex.org/W6768743507","https://openalex.org/W6784653527","https://openalex.org/W6786048916","https://openalex.org/W6798105513"],"related_works":["https://openalex.org/W73545470","https://openalex.org/W4224266612","https://openalex.org/W2383394264","https://openalex.org/W4320153225","https://openalex.org/W4293261942","https://openalex.org/W3125968744","https://openalex.org/W2167701463","https://openalex.org/W2110287964","https://openalex.org/W4307407935","https://openalex.org/W649759291"],"abstract_inverted_index":{"Identification":[0],"of":[1,11,36,76,83,133],"brain":[2,42,65],"regions":[3,75,86],"related":[4],"to":[5,55,72],"the":[6,32,48,57,81,100,103,120,131],"specific":[7],"neurological":[8],"disorders":[9],"are":[10],"great":[12],"importance":[13],"for":[14,31,129],"biomarker":[15],"and":[16,34,95,115,117,138,150],"diagnostic":[17],"studies.":[18],"In":[19],"this":[20],"paper,":[21],"we":[22,46],"propose":[23],"an":[24],"interpretable":[25],"Graph":[26],"Convolutional":[27],"Network":[28],"(GCN)":[29],"framework":[30],"identification":[33],"classification":[35],"Alzheimer\u2019s":[37],"disease":[38,139],"(AD)":[39],"using":[40],"multi-modality":[41],"imaging":[43,107],"data.":[44],"Specifically,":[45],"extended":[47],"Gradient":[49],"Class":[50],"Activation":[51],"Mapping":[52],"(Grad-CAM)":[53],"technique":[54],"quantify":[56],"most":[58],"discriminative":[59],"features":[60,84,122],"identified":[61,145],"by":[62,79,124],"GCN":[63],"from":[64,109],"connectivity":[66],"patterns.":[67],"We":[68,98],"then":[69],"utilized":[70],"them":[71],"find":[73],"signature":[74],"interest":[77],"(ROIs)":[78],"detecting":[80],"difference":[82],"between":[85],"in":[87],"healthy":[88],"control":[89],"(HC),":[90],"mild":[91],"cognitive":[92],"impairment":[93],"(MCI),":[94],"AD":[96,149],"groups.":[97],"conducted":[99],"experiments":[101],"on":[102],"ADNI":[104],"database":[105],"with":[106,148],"data":[108],"three":[110],"modalities,":[111],"including":[112],"VBM-MRI,":[113],"FDG-PET,":[114],"AV45-PET,":[116],"showed":[118],"that":[119],"ROI":[121],"learned":[123],"our":[125],"method":[126],"were":[127],"effective":[128],"enhancing":[130],"performances":[132],"both":[134],"clinical":[135],"score":[136],"prediction":[137],"status":[140],"identification.":[141],"It":[142],"also":[143],"successfully":[144],"biomarkers":[146],"associated":[147],"MCI.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}