{"id":"https://openalex.org/W4224997907","doi":"https://doi.org/10.1109/isbi52829.2022.9761424","title":"Structural Brain Atrophy Predict Symptom Severity in Schizophrenia Based on Generalized Additive Models","display_name":"Structural Brain Atrophy Predict Symptom Severity in Schizophrenia Based on Generalized Additive Models","publication_year":2022,"publication_date":"2022-03-28","ids":{"openalex":"https://openalex.org/W4224997907","doi":"https://doi.org/10.1109/isbi52829.2022.9761424"},"language":"en","primary_location":{"id":"doi:10.1109/isbi52829.2022.9761424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761424","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100377168","display_name":"Meng Wang","orcid":"https://orcid.org/0000-0002-5198-7613"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Wang","raw_affiliation_strings":["Institute of Automation, Chinese Academy of Sciences,Brainnetome Center and National Laboratory of Pattern Recognition,Beijing,China","Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Automation, Chinese Academy of Sciences,Brainnetome Center and National Laboratory of Pattern Recognition,Beijing,China","institution_ids":["https://openalex.org/I4210112150"]},{"raw_affiliation_string":"Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I19820366"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210100255","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060635963","display_name":"Lingzhong Fan","orcid":"https://orcid.org/0000-0002-4813-621X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingzhong Fan","raw_affiliation_strings":["Institute of Automation, Chinese Academy of Sciences,Brainnetome Center and National Laboratory of Pattern Recognition,Beijing,China","Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Automation, Chinese Academy of Sciences,Brainnetome Center and National Laboratory of Pattern Recognition,Beijing,China","institution_ids":["https://openalex.org/I4210112150"]},{"raw_affiliation_string":"Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I19820366"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210100255","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109831307","display_name":"Bing Liu","orcid":"https://orcid.org/0000-0003-2029-5187"},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]},{"id":"https://openalex.org/I4391768142","display_name":"State Key Laboratory of Cognitive Neuroscience and Learning","ror":"https://ror.org/059y0zb32","country_code":null,"type":"facility","lineage":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Liu","raw_affiliation_strings":["Beijing Normal University,State Key Laboratory of Cognitive Neuroscience and Learning,Beijing,China","State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China","Chinese Institute for Brain Research, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Normal University,State Key Laboratory of Cognitive Neuroscience and Learning,Beijing,China","institution_ids":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]},{"raw_affiliation_string":"State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941"]},{"raw_affiliation_string":"Chinese Institute for Brain Research, Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02908668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.7829611301422119},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.6595533490180969},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.585008978843689},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.38257476687431335},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3639819622039795},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.35950490832328796},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.31444883346557617},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.2851715087890625}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7829611301422119},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6595533490180969},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.585008978843689},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38257476687431335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3639819622039795},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35950490832328796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31444883346557617},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2851715087890625},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi52829.2022.9761424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761424","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education","score":0.6399999856948853}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1935126539","https://openalex.org/W1990420052","https://openalex.org/W1998025025","https://openalex.org/W2003366144","https://openalex.org/W2097998348","https://openalex.org/W2101135654","https://openalex.org/W2103691876","https://openalex.org/W2110208125","https://openalex.org/W2110437310","https://openalex.org/W2123986712","https://openalex.org/W2134266651","https://openalex.org/W2140606211","https://openalex.org/W2151721316","https://openalex.org/W2154776925","https://openalex.org/W2155298532","https://openalex.org/W2157355630","https://openalex.org/W2163058355","https://openalex.org/W2402346616","https://openalex.org/W2421101021","https://openalex.org/W2751597636","https://openalex.org/W2782069613","https://openalex.org/W2804287612","https://openalex.org/W2998678080","https://openalex.org/W4238293282","https://openalex.org/W4297872986","https://openalex.org/W6630956611","https://openalex.org/W6674385629","https://openalex.org/W6682981795"],"related_works":["https://openalex.org/W4205713785","https://openalex.org/W3016766501","https://openalex.org/W4398287560","https://openalex.org/W4398914716","https://openalex.org/W4398619072","https://openalex.org/W4398556994","https://openalex.org/W4398472861","https://openalex.org/W4398934068","https://openalex.org/W4398686282","https://openalex.org/W4398870170"],"abstract_inverted_index":{"Schizophrenia":[0],"(SCZ)":[1],"patients":[2],"typically":[3],"vary":[4],"significantly":[5],"in":[6,39,61,80,148,154],"symptom":[7,33,89,112],"severity.":[8,34],"Despite":[9],"numerous":[10],"studies":[11],"demonstrate":[12],"SCZ":[13,44,52],"is":[14],"linked":[15],"to":[16,87],"brain":[17],"structure":[18],"abnormalities,":[19],"relationships":[20,28],"are":[21,37],"obscure.":[22],"In":[23],"this":[24],"paper,":[25],"we":[26,67,83],"establish":[27],"between":[29],"structural":[30,103],"abnormalities":[31],"and":[32,45,53,76,95],"All":[35],"analyses":[36],"performed":[38],"two":[40,115],"datasets":[41,116],"(discovery:":[42,117],"326":[43],"298":[46],"normal":[47],"control":[48],"(NC);":[49],"replication:":[50,131],"216":[51],"173":[54],"NC).":[55],"We":[56,105],"first":[57],"build":[58],"normative":[59],"models":[60,94],"NC":[62],"group,":[63],"based":[64],"on":[65],"which":[66],"calculate":[68],"atrophy":[69,85,107],"values":[70,86,108],"of":[71,101,152],"cortical":[72],"thickness,":[73],"surface":[74],"area,":[75],"gray":[77],"matter":[78],"volume":[79],"SCZ.":[81,155],"Finally,":[82],"use":[84],"predict":[88,111],"severity":[90,113],"via":[91],"generalized":[92],"additive":[93],"further":[96],"evaluate":[97],"the":[98,150],"marginal":[99],"effect":[100],"each":[102],"feature.":[104],"found":[106],"could":[109,146],"reliably":[110],"across":[114],"Pearson":[118],"r":[119,132],"=":[120,133,136],"0.29,":[121],"P":[122,135],"<":[123],"1":[124],"\u00d7":[125,138],"10":[126,139],"<sup":[127,140],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[128,141],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-5</sup>":[129,142],";":[130],"0.26,":[134],"3":[137],").":[143],"Our":[144],"findings":[145],"aid":[147],"understanding":[149],"pathogenesis":[151],"symptoms":[153]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}