{"id":"https://openalex.org/W3165352118","doi":"https://doi.org/10.1109/isbi48211.2021.9434143","title":"Predicting Progression from Mild Cognitive Impairment to Alzheimer\u2019s Disease using MRI-based Cortical Features and a Two-State Markov Model","display_name":"Predicting Progression from Mild Cognitive Impairment to Alzheimer\u2019s Disease using MRI-based Cortical Features and a Two-State Markov Model","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3165352118","doi":"https://doi.org/10.1109/isbi48211.2021.9434143","mag":"3165352118","pmid":"https://pubmed.ncbi.nlm.nih.gov/35321154"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9434143","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2318/1789968","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004250774","display_name":"Eleonora Ficiar\u00e0","orcid":"https://orcid.org/0000-0001-7986-0553"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Eleonora Ficiara","raw_affiliation_strings":["Department of Neurosciences, University of Turin, Italy","University of Turin, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023927039","display_name":"Valentino Crespi","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentino Crespi","raw_affiliation_strings":["Information Sciences Institute (ISI), AI Division, University of Southern California, USA"],"affiliations":[{"raw_affiliation_string":"Information Sciences Institute (ISI), AI Division, University of Southern California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071616032","display_name":"Shruti Prashant Gadewar","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166946","display_name":"Imaging Center","ror":"https://ror.org/05hsqsk33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Prashant Gadewar","raw_affiliation_strings":["Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","institution_ids":["https://openalex.org/I4210166946"]},{"raw_affiliation_string":"Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017365268","display_name":"Sophia I. Thomopoulos","orcid":"https://orcid.org/0000-0002-0046-4070"},"institutions":[{"id":"https://openalex.org/I4210166946","display_name":"Imaging Center","ror":"https://ror.org/05hsqsk33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia I. Thomopoulos","raw_affiliation_strings":["Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","institution_ids":["https://openalex.org/I4210166946"]},{"raw_affiliation_string":"Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053233770","display_name":"Joshua Boyd","orcid":"https://orcid.org/0000-0002-6751-1628"},"institutions":[{"id":"https://openalex.org/I4210166946","display_name":"Imaging Center","ror":"https://ror.org/05hsqsk33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Boyd","raw_affiliation_strings":["Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","institution_ids":["https://openalex.org/I4210166946"]},{"raw_affiliation_string":"Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I4210166946","display_name":"Imaging Center","ror":"https://ror.org/05hsqsk33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","institution_ids":["https://openalex.org/I4210166946"]},{"raw_affiliation_string":"Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950"},"institutions":[{"id":"https://openalex.org/I4210166946","display_name":"Imaging Center","ror":"https://ror.org/05hsqsk33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA"],"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA","institution_ids":["https://openalex.org/I4210166946"]},{"raw_affiliation_string":"Keck School of Medicine of USC, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Marina del Rey, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021436143","display_name":"Fabrizio Pizzagalli","orcid":"https://orcid.org/0000-0003-4582-0224"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Pizzagalli","raw_affiliation_strings":["Department of Neurosciences, University of Turin, Italy","University of Turin, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5004250774"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":0.1187,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40717836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2021","issue":null,"first_page":"1145","last_page":"1149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gyrification","display_name":"Gyrification","score":0.8016722798347473},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.6745020747184753},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.6459159851074219},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5936131477355957},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.5386258363723755},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5220537185668945},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.48417335748672485},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.45705223083496094},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.44893133640289307},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.43241867423057556},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41496461629867554},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.35982537269592285},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.20825818181037903},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.19090762734413147}],"concepts":[{"id":"https://openalex.org/C2780914113","wikidata":"https://www.wikidata.org/wiki/Q19468049","display_name":"Gyrification","level":3,"score":0.8016722798347473},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6745020747184753},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6459159851074219},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5936131477355957},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5386258363723755},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5220537185668945},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.48417335748672485},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45705223083496094},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44893133640289307},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43241867423057556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41496461629867554},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.35982537269592285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20825818181037903},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19090762734413147}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi48211.2021.9434143","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:35321154","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35321154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:iris.unito.it:2318/1789968","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1789968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:pubmedcentral.nih.gov:8935949","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8935949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:iris.unito.it:2318/1789968","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1789968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1486708136","https://openalex.org/W1999832023","https://openalex.org/W2010600798","https://openalex.org/W2012603004","https://openalex.org/W2016629996","https://openalex.org/W2038003677","https://openalex.org/W2143017382","https://openalex.org/W2153631628","https://openalex.org/W2579987562","https://openalex.org/W2580162924","https://openalex.org/W2594998925","https://openalex.org/W2790250792","https://openalex.org/W2796087592","https://openalex.org/W2884046250","https://openalex.org/W2896165108","https://openalex.org/W2964278775","https://openalex.org/W3046982038","https://openalex.org/W3087552014","https://openalex.org/W6732094231"],"related_works":["https://openalex.org/W2025453479","https://openalex.org/W4388417611","https://openalex.org/W2444574782","https://openalex.org/W2088198702","https://openalex.org/W2038213387","https://openalex.org/W2105113370","https://openalex.org/W3037836458","https://openalex.org/W2150970214","https://openalex.org/W2048029629","https://openalex.org/W2074243908"],"abstract_inverted_index":{"Magnetic":[0],"resonance":[1],"imaging":[2],"(MRI)":[3],"has":[4,33],"a":[5,86],"potential":[6],"for":[7,14],"early":[8],"diagnosis":[9],"of":[10,38,79],"individuals":[11],"at":[12],"risk":[13],"developing":[15],"Alzheimer's":[16,81],"disease":[17],"(AD).":[18],"Cognitive":[19],"performance":[20],"in":[21,26],"healthy":[22],"elderly":[23],"people":[24],"and":[25,42,60,77],"those":[27],"with":[28,36,72],"mild":[29],"cognitive":[30],"impairment":[31],"(MCI)":[32],"been":[34],"associated":[35],"measures":[37,52,63],"cortical":[39,105],"gyrification":[40],"[1]":[41],"thickness":[43],"(CT)":[44],"[2],":[45],"yet":[46],"the":[47,80,92],"extent":[48],"to":[49,55,90,96,112,117],"which":[50],"sulcal":[51,108],"can":[53],"help":[54,111],"predict":[56,113],"AD":[57,97],"conversion":[58,93,114],"above":[59],"beyond":[61],"CT":[62],"is":[64],"not":[65],"known.":[66],"Here,":[67],"we":[68],"analyzed":[69],"721":[70],"participants":[71],"MCI":[73,95,116],"from":[74,94,115],"phases":[75],"1":[76],"2":[78],"Disease":[82],"Neuroimaging":[83],"Initiative,":[84],"applying":[85],"two-state":[87],"Markov":[88],"model":[89],"study":[91],"condition.":[98],"Our":[99],"preliminary":[100],"results":[101],"suggest":[102],"that":[103],"MRI-based":[104],"features,":[106],"including":[107],"morphometry,":[109],"may":[110],"AD.":[118]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}