{"id":"https://openalex.org/W3165572138","doi":"https://doi.org/10.1109/isbi48211.2021.9434127","title":"Joint Segmentation Of Multiple Sclerosis Lesions And Brain Anatomy In MRI Scans Of Any Contrast And Resolution With CNNs","display_name":"Joint Segmentation Of Multiple Sclerosis Lesions And Brain Anatomy In MRI Scans Of Any Contrast And Resolution With CNNs","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3165572138","doi":"https://doi.org/10.1109/isbi48211.2021.9434127","mag":"3165572138","pmid":"https://pubmed.ncbi.nlm.nih.gov/34367472"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9434127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434127","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8340983","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036774610","display_name":"Benjamin Billot","orcid":"https://orcid.org/0000-0002-3018-1282"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Benjamin Billot","raw_affiliation_strings":["Center for Medical Image Computing, University College London, UK"],"affiliations":[{"raw_affiliation_string":"Center for Medical Image Computing, University College London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008611288","display_name":"Stefano Cerri","orcid":"https://orcid.org/0000-0002-5212-3294"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stefano Cerri","raw_affiliation_strings":["Department of Health Technology, Technical University of Denmark, Denmark","Technical University of Denmark, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Health Technology, Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047520245","display_name":"Koen Van Leemput","orcid":"https://orcid.org/0000-0001-6466-5309"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Koen Van Leemput","raw_affiliation_strings":["Department of Health Technology, Technical University of Denmark, Denmark","Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA","Technical University of Denmark, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Health Technology, Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091409910","display_name":"Adrian V. Dalca","orcid":"https://orcid.org/0000-0002-8422-0136"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian V. Dalca","raw_affiliation_strings":["Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA","Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA"],"affiliations":[{"raw_affiliation_string":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054888342","display_name":"Juan Eugenio Iglesias","orcid":"https://orcid.org/0000-0001-7569-173X"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Juan Eugenio Iglesias","raw_affiliation_strings":["Center for Medical Image Computing, University College London, UK","Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA","Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA"],"affiliations":[{"raw_affiliation_string":"Center for Medical Image Computing, University College London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036774610"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":1.1655,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80458415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2021","issue":null,"first_page":"1971","last_page":"1974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.781659722328186},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7382476329803467},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6883739233016968},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6085695028305054},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.5087485909461975},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.46725746989250183},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.44506195187568665},{"id":"https://openalex.org/keywords/partial-volume","display_name":"Partial volume","score":0.4309334456920624},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.422590047121048},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.41598784923553467},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.4140205383300781},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.2123304307460785}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.781659722328186},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7382476329803467},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6883739233016968},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6085695028305054},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5087485909461975},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.46725746989250183},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.44506195187568665},{"id":"https://openalex.org/C82233179","wikidata":"https://www.wikidata.org/wiki/Q2054500","display_name":"Partial volume","level":2,"score":0.4309334456920624},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.422590047121048},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.41598784923553467},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.4140205383300781},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.2123304307460785}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi48211.2021.9434127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434127","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:34367472","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34367472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8340983","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8340983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/426341f6-401e-4faa-b3da-d233754855e6","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/426341f6-401e-4faa-b3da-d233754855e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Billot , B , Cerri , S , Leemput , K V , Dalca , A V &amp; Iglesias , J E 2021 , Joint segmentation of multiple sclerosis lesions and brain anatomy in mri scans of any contrast and resolution with CNNs . in Proceedings of the 18th International Symposium on Biomedical Imaging . IEEE , Proceedings - International Symposium on Biomedical Imaging , pp. 1971-1974 , 2021 IEEE International Symposium on Biomedical Imaging , Nice , France , 13/04/2021 . https://doi.org/10.1109/ISBI48211.2021.9434127","raw_type":"contributionToPeriodical"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8340983","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8340983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320217","display_name":"Marie Curie","ror":"https://ror.org/02aqv1x10"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1579576867","https://openalex.org/W1901129140","https://openalex.org/W2041823936","https://openalex.org/W2091753181","https://openalex.org/W2164167069","https://openalex.org/W2301358467","https://openalex.org/W2319459971","https://openalex.org/W2474584762","https://openalex.org/W2604830170","https://openalex.org/W2849179291","https://openalex.org/W2963052998","https://openalex.org/W2964262389","https://openalex.org/W2995209110","https://openalex.org/W3009445070","https://openalex.org/W3021605584","https://openalex.org/W4241074797","https://openalex.org/W4321760728","https://openalex.org/W6639824700","https://openalex.org/W6752013982","https://openalex.org/W6774266105","https://openalex.org/W6777007596"],"related_works":["https://openalex.org/W2075740387","https://openalex.org/W2069592018","https://openalex.org/W4391621807","https://openalex.org/W2358990940","https://openalex.org/W2162426787","https://openalex.org/W2093931120","https://openalex.org/W2329812990","https://openalex.org/W2349116365","https://openalex.org/W3021708704","https://openalex.org/W1977541817"],"abstract_inverted_index":{"We":[0,116],"present":[1],"the":[2,38,71,79,104],"first":[3],"deep":[4],"learning":[5],"method":[6,26,60,119],"to":[7,30,44,55,64],"segment":[8,65],"Multiple":[9],"Sclerosis":[10],"lesions":[11],"and":[12,23,106,134],"brain":[13],"structures":[14],"from":[15],"MRI":[16],"scans":[17,47,81],"of":[18,41,73],"any":[19,67],"(possibly":[20],"multimodal)":[21],"contrast":[22],"resolution.":[24],"Our":[25,59],"only":[27],"requires":[28],"segmentations":[29],"be":[31,62],"trained":[32,138],"(no":[33],"images),":[34],"as":[35],"it":[36,125],"leverages":[37],"generative":[39],"model":[40],"Bayesian":[42,129],"segmentation":[43],"generate":[45],"synthetic":[46,80],"with":[48,85,91,95,126],"simulated":[49],"lesions,":[50],"which":[51,88],"are":[52,82,101],"then":[53],"used":[54],"train":[56],"a":[57,127],"CNN.":[58],"can":[61],"retrained":[63],"at":[66,146],"resolution":[68],"by":[69],"adjusting":[70],"amount":[72],"synthesised":[74],"partial":[75],"volume.":[76],"By":[77],"construction,":[78],"perfectly":[83],"aligned":[84],"their":[86],"labels,":[87],"enables":[89],"training":[90,99],"noisy":[92],"labels":[93],"obtained":[94],"automatic":[96],"methods.":[97],"The":[98,142],"data":[100],"generated":[102],"on":[103,120,139],"fly,":[105],"aggressive":[107],"augmentation":[108],"(including":[109],"artefacts)":[110],"is":[111,144],"applied":[112],"for":[113],"improved":[114],"generalisation.":[115],"demonstrate":[117],"our":[118],"two":[121],"public":[122],"datasets,":[123],"comparing":[124],"state-of-the-art":[128],"approach":[130],"implemented":[131],"in":[132],"FreeSurfer,":[133],"dataset":[135],"specific":[136],"CNNs":[137],"real":[140],"data.":[141],"code":[143],"available":[145],"https://github.com/BBillot/SynthSeg.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
