{"id":"https://openalex.org/W3164914517","doi":"https://doi.org/10.1109/isbi48211.2021.9434076","title":"Delta-Radiomics Signature For Prediction Of Survival In Advanced Nsclc Patients Treated With Immunotherapy","display_name":"Delta-Radiomics Signature For Prediction Of Survival In Advanced Nsclc Patients Treated With Immunotherapy","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3164914517","doi":"https://doi.org/10.1109/isbi48211.2021.9434076","mag":"3164914517"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9434076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014530551","display_name":"Benito Farina","orcid":"https://orcid.org/0000-0003-1674-5907"},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"B. Farina","raw_affiliation_strings":["Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain","institution_ids":["https://openalex.org/I88060688","https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065566752","display_name":"Ana Delia Ramos Guerra","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. D. Ramos Guerra","raw_affiliation_strings":["Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain","institution_ids":["https://openalex.org/I88060688","https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083734285","display_name":"Carmelo Palacios Miras","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Palacios Miras","raw_affiliation_strings":["Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009339447","display_name":"Guillermo Gallardo Madue\u00f1o","orcid":"https://orcid.org/0000-0002-7502-3544"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G. Gallardo Madueno","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain"],"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022934126","display_name":"Arrate Mu\u00f1oz\u2010Barrutia","orcid":"https://orcid.org/0000-0002-1573-1661"},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arrate Munoz-Barrutia","raw_affiliation_strings":["Dpto.Bioingenieria e Ingenier\u00eda Aeroespacial, Universidad Carlos III de Madrid & IDISNA, Spain"],"affiliations":[{"raw_affiliation_string":"Dpto.Bioingenieria e Ingenier\u00eda Aeroespacial, Universidad Carlos III de Madrid & IDISNA, Spain","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108749098","display_name":"Germn Peces-Barba","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G. R. Peces-Barba","raw_affiliation_strings":["Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Seijo Maceiras","orcid":null},"institutions":[{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. Seijo Maceiras","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra & CIBERES, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra & CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210115082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109140109","display_name":"J. Corral","orcid":null},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Corral","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain"],"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072987179","display_name":"Ignacio Gil\u2010Bazo","orcid":"https://orcid.org/0000-0002-2626-5109"},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I. Gil-Bazo","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain"],"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra & CIBERONC & IDISNA, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103965370","display_name":"M. D\u00f3mine G\u00f3mez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Domine Gomez","raw_affiliation_strings":["Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz & CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012910949","display_name":"Mar\u00eda J. Ledesma\u2010Carbayo","orcid":"https://orcid.org/0000-0001-6846-3923"},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. J. Ledesma-Carbayo","raw_affiliation_strings":["Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Biomedical Image Technologies, Universidad Polit\u00e9cnica de Madrid & CIBER-BBN, Madrid, Spain","institution_ids":["https://openalex.org/I88060688","https://openalex.org/I4210105141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5014530551"],"corresponding_institution_ids":["https://openalex.org/I4210105141","https://openalex.org/I88060688"],"apc_list":null,"apc_paid":null,"fwci":0.2785,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56199715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"84","issue":null,"first_page":"886","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.8862158060073853},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.7186703681945801},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6956549286842346},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.6348840594291687},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6333965063095093},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5817593336105347},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5753626823425293},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5689529180526733},{"id":"https://openalex.org/keywords/imaging-biomarker","display_name":"Imaging biomarker","score":0.48260462284088135},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.433495432138443},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3702878952026367},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3586377501487732},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.10353004932403564}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.8862158060073853},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7186703681945801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6956549286842346},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6348840594291687},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6333965063095093},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5817593336105347},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5753626823425293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5689529180526733},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.48260462284088135},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.433495432138443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3702878952026367},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3586377501487732},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.10353004932403564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi48211.2021.9434076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1757407923","https://openalex.org/W2036382630","https://openalex.org/W2174661749","https://openalex.org/W2264807809","https://openalex.org/W2285287574","https://openalex.org/W2570618306","https://openalex.org/W2737082469","https://openalex.org/W2755806371","https://openalex.org/W2767128594","https://openalex.org/W2900498974","https://openalex.org/W2904258904","https://openalex.org/W2983529249","https://openalex.org/W2996506557","https://openalex.org/W3046430433","https://openalex.org/W6769662423"],"related_works":["https://openalex.org/W3000891326","https://openalex.org/W4205100762","https://openalex.org/W2734724112","https://openalex.org/W2582997534","https://openalex.org/W3009210156","https://openalex.org/W2183151932","https://openalex.org/W1987682868","https://openalex.org/W3037682612","https://openalex.org/W2792347954","https://openalex.org/W4281753435"],"abstract_inverted_index":{"with":[0,61,105,115],"an":[1,116,128,141],"approximate":[2],"5-years":[3],"survival":[4,55],"rate":[5],"of":[6,12,25,31,44,125,137,144],"13%":[7],"from":[8,81],"diagnosis.":[9],"The":[10,42,90,132],"potential":[11,136],"computational":[13],"image":[14],"analysis":[15],"to":[16,36,40,48,53,87,139],"provide":[17],"decision":[18],"support":[19],"in":[20,59,127],"oncology":[21],"and":[22,28,34,56,71,76,78,111],"the":[23,119,135],"importance":[24],"identifying":[26],"predictive":[27],"non-invasive":[29],"biomarkers":[30],"disease":[32],"progression":[33],"response":[35,58],"therapy":[37],"has":[38],"led":[39],"Radiomics.":[41],"objective":[43],"this":[45],"study":[46],"was":[47,102],"develop":[49],"a":[50],"delta-radiomics":[51,138],"signature":[52,92],"predict":[54],"treatment":[57],"patients":[60,83,97],"advanced":[62],"non-small":[63],"cell":[64],"lung":[65],"cancer":[66],"(NSCLC)":[67],"undergoing":[68],"immunotherapy.":[69],"Pre-treatment":[70],"first":[72],"follow-up":[73],"CT":[74],"images":[75],"intra-nodular":[77],"peri-nodular":[79],"regions":[80],"88":[82],"have":[84],"been":[85],"used":[86],"calculate":[88],"delta-features.":[89],"deltaradiomics":[91],"significantly":[93,103],"stratified":[94],"highand":[95],"low-risk":[96],"(p":[98,108],"=":[99,109],"0.018),":[100],"it":[101,112],"associated":[104],"Overall":[106],"Survival":[107],"0.03)":[110],"predicted":[113],"responders":[114],"area":[117],"under":[118],"receiver":[120],"operating":[121],"characteristic":[122],"curve":[123],"(ROC-AUC)":[124],"0.76":[126],"independent":[129],"test":[130],"set.":[131],"results":[133],"demonstrate":[134],"be":[140],"early":[142],"biomarker":[143],"immunotherapy":[145],"response.":[146]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}