{"id":"https://openalex.org/W3164658214","doi":"https://doi.org/10.1109/isbi48211.2021.9434015","title":"Comparative Study Of Voxel-Based Statistical Analysis Methods For Fluorescently Labelled And Light Sheet Imaged Whole-Brain Samples","display_name":"Comparative Study Of Voxel-Based Statistical Analysis Methods For Fluorescently Labelled And Light Sheet Imaged Whole-Brain Samples","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3164658214","doi":"https://doi.org/10.1109/isbi48211.2021.9434015","mag":"3164658214"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9434015","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434015","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075910802","display_name":"Johanna Perens","orcid":"https://orcid.org/0000-0002-0417-5647"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]},{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Johanna Perens","raw_affiliation_strings":["Gubra ApS, H\u00f8rsholm, Denmark","Technical University Denmark, Kongens Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]},{"raw_affiliation_string":"Technical University Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001538485","display_name":"Jacob Lercke Skytte","orcid":"https://orcid.org/0000-0003-0313-2124"},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob Lercke Skytte","raw_affiliation_strings":["Gubra ApS, H\u00f8rsholm, Denmark"],"affiliations":[{"raw_affiliation_string":"Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103980615","display_name":"Casper Gravesen Salinas","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Casper Gravesen Salinas","raw_affiliation_strings":["Gubra ApS, H\u00f8rsholm, Denmark"],"affiliations":[{"raw_affiliation_string":"Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067103368","display_name":"Jacob Hecksher\u2010S\u00f8rensen","orcid":"https://orcid.org/0000-0002-5516-6177"},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob Hecksher-Sorensen","raw_affiliation_strings":["Gubra ApS, H\u00f8rsholm, Denmark"],"affiliations":[{"raw_affiliation_string":"Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102857785","display_name":"Tim B. Dyrby","orcid":"https://orcid.org/0000-0003-3361-9734"},"institutions":[{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tim B. Dyrby","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark","Technical University Denmark, Kongens Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Technical University Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031953389","display_name":"Anders Bjorholm Dahl","orcid":"https://orcid.org/0000-0002-0068-8170"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Bjorholm Dahl","raw_affiliation_strings":["Technical University Denmark, Kongens Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"Technical University Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075910802"],"corresponding_institution_ids":["https://openalex.org/I4210113742","https://openalex.org/I96673099"],"apc_list":null,"apc_paid":null,"fwci":0.7499,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.81470809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1433","last_page":"1437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.8522096872329712},{"id":"https://openalex.org/keywords/clearance","display_name":"Clearance","score":0.7282673120498657},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6962478160858154},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.674189567565918},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.6541358232498169},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"Statistical analysis","score":0.5356236696243286},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5178797245025635},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.48515424132347107},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.43134066462516785},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.42046529054641724},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.37520334124565125},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.18739408254623413},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14671635627746582},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1245373785495758},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11596912145614624},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09791454672813416}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.8522096872329712},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.7282673120498657},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6962478160858154},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.674189567565918},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.6541358232498169},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.5356236696243286},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5178797245025635},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.48515424132347107},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.43134066462516785},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.42046529054641724},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.37520334124565125},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18739408254623413},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14671635627746582},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1245373785495758},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11596912145614624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09791454672813416},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi48211.2021.9434015","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434015","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:publications/d7c281e1-e7b8-46ea-8210-4d6c31c1d1c0","is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/d7c281e1-e7b8-46ea-8210-4d6c31c1d1c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Perens , J , Skytte , J L , Salinas , C G , Hecksher-Sorensen , J , Dyrby , T B &amp; Dahl , A B 2021 , Comparative Study of Voxel-Based Statistical Analysis Methods For Fluorescently Labelled And Light Sheet Imaged Whole-Brain Samples . in Proceedings of 2021 IEEE 18 th International Symposium on Biomedical Imaging . IEEE , International Symposium on Biomedical Imaging. Proceedings , pp. 1433-7 , 2021 IEEE International Symposium on Biomedical Imaging , Nice , France , 13/04/2021 . https://doi.org/10.1109/ISBI48211.2021.9434015","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1976954310","https://openalex.org/W1983439565","https://openalex.org/W2010956007","https://openalex.org/W2017687738","https://openalex.org/W2046557060","https://openalex.org/W2061554433","https://openalex.org/W2068391384","https://openalex.org/W2076507262","https://openalex.org/W2110065044","https://openalex.org/W2133287637","https://openalex.org/W2165757806","https://openalex.org/W2171652727","https://openalex.org/W2203529929","https://openalex.org/W2408110716","https://openalex.org/W2465504877","https://openalex.org/W2512571444","https://openalex.org/W2619656223","https://openalex.org/W2756343653","https://openalex.org/W2894759110","https://openalex.org/W2900866106","https://openalex.org/W2901190383","https://openalex.org/W2985988766","https://openalex.org/W2995153909","https://openalex.org/W3012419064","https://openalex.org/W3013242926","https://openalex.org/W3015433078","https://openalex.org/W3092234123","https://openalex.org/W3092695059","https://openalex.org/W6738082915"],"related_works":["https://openalex.org/W2350702655","https://openalex.org/W2319685803","https://openalex.org/W2026012944","https://openalex.org/W2359486277","https://openalex.org/W2289334277","https://openalex.org/W2785984867","https://openalex.org/W2355334280","https://openalex.org/W3122113541","https://openalex.org/W3123376079","https://openalex.org/W2062963425"],"abstract_inverted_index":{"Light":[0],"sheet":[1],"microscopy":[2],"of":[3,22,51,124,138],"fluorescently":[4],"labelled":[5],"and":[6,20,36,44,84,120],"optically":[7],"cleared":[8],"intact":[9],"organs":[10],"is":[11,29,78],"a":[12,94,112,125,134],"novel":[13],"approach":[14,73],"which":[15],"enables":[16],"to":[17,142],"visualize":[18],"structure":[19],"function":[21],"the":[23,33,55,81,90,102,122],"brain":[24,68],"in":[25,32,133],"3D.":[26],"The":[27],"methodology":[28],"gaining":[30],"popularity":[31],"neuroscience":[34],"community":[35],"dedicated":[37],"algorithms":[38],"are":[39,58],"being":[40],"developed":[41],"for":[42,65,115],"segmenting":[43],"quantifying":[45],"different":[46,140],"neurological":[47],"markers.":[48],"However,":[49],"comparisons":[50,119],"marker":[52],"characteristics":[53],"between":[54],"study":[56,137],"groups":[57],"conventionally":[59],"performed":[60],"by":[61,80],"conducting":[62,116],"statistical":[63,72,144],"testing":[64],"every":[66],"atlas-defined":[67],"region.":[69],"While":[70],"this":[71,98],"yields":[74],"viable":[75],"results,":[76],"it":[77],"biased":[79],"region":[82],"delineations":[83],"does":[85],"not":[86],"provide":[87],"information":[88],"on":[89],"signal":[91,105],"properties":[92],"at":[93],"voxel":[95],"level.":[96],"In":[97],"work,":[99],"we":[100],"convert":[101],"3D":[103],"histological":[104],"from":[106],"segmented":[107],"c-Fos":[108],"+":[109],"cells":[110],"into":[111],"format":[113],"suitable":[114],"voxel-wise":[117],"group":[118],"demonstrate":[121],"potential":[123],"recent":[126],"technique,":[127],"probabilistic":[128],"threshold-free":[129],"cluster":[130],"enhancement":[131],"method,":[132],"brief":[135],"comparative":[136],"six":[139],"approaches":[141],"voxel-based":[143],"analysis.":[145]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
