{"id":"https://openalex.org/W3165804912","doi":"https://doi.org/10.1109/isbi48211.2021.9434012","title":"Attention-guided Deep Multi-instance Learning for Staging Retinopathy of Prematurity","display_name":"Attention-guided Deep Multi-instance Learning for Staging Retinopathy of Prematurity","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3165804912","doi":"https://doi.org/10.1109/isbi48211.2021.9434012","mag":"3165804912"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9434012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005571749","display_name":"Shaobin Chen","orcid":"https://orcid.org/0000-0002-2306-1856"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaobin Chen","raw_affiliation_strings":["National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076541737","display_name":"Rugang Zhang","orcid":"https://orcid.org/0000-0002-7255-2360"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rugang Zhang","raw_affiliation_strings":["National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101566544","display_name":"Guozhen Chen","orcid":"https://orcid.org/0000-0003-4598-8879"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guozhen Chen","raw_affiliation_strings":["National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108276369","display_name":"Jinfeng Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]},{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Zhao","raw_affiliation_strings":["Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, The Second Affiliated Hospital of Jinan University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, The Second Affiliated Hospital of Jinan University, Shenzhen, China","institution_ids":["https://openalex.org/I4210164332","https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046543349","display_name":"Tianfu Wang","orcid":"https://orcid.org/0000-0002-1248-1214"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianfu Wang","raw_affiliation_strings":["National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618997","display_name":"Guoming Zhang","orcid":"https://orcid.org/0000-0003-2123-8125"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoming Zhang","raw_affiliation_strings":["Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, The Second Affiliated Hospital of Jinan University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, The Second Affiliated Hospital of Jinan University, Shenzhen, China","institution_ids":["https://openalex.org/I4210164332","https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001212991","display_name":"Baiying Lei","orcid":"https://orcid.org/0000-0002-3087-2550"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baiying Lei","raw_affiliation_strings":["National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"National-Regional Key Technology Engineering Laboratory for MedicalUltrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5005571749"],"corresponding_institution_ids":["https://openalex.org/I4210145292"],"apc_list":null,"apc_paid":null,"fwci":0.9622,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74668263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1025","last_page":"1028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"Retinopathy of prematurity","score":0.8800448179244995},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7393288612365723},{"id":"https://openalex.org/keywords/childhood-blindness","display_name":"Childhood blindness","score":0.6141886115074158},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6066399812698364},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5896937251091003},{"id":"https://openalex.org/keywords/fundus","display_name":"Fundus (uterus)","score":0.5724809765815735},{"id":"https://openalex.org/keywords/blindness","display_name":"Blindness","score":0.5567754507064819},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4955240488052368},{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.48860055208206177},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.46913784742355347},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.46775010228157043},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3472660183906555},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34479841589927673},{"id":"https://openalex.org/keywords/optometry","display_name":"Optometry","score":0.21916592121124268},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1897643804550171},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.12952697277069092},{"id":"https://openalex.org/keywords/gestational-age","display_name":"Gestational age","score":0.06341373920440674}],"concepts":[{"id":"https://openalex.org/C2779918416","wikidata":"https://www.wikidata.org/wiki/Q1423087","display_name":"Retinopathy of prematurity","level":4,"score":0.8800448179244995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7393288612365723},{"id":"https://openalex.org/C2779531571","wikidata":"https://www.wikidata.org/wiki/Q18387303","display_name":"Childhood blindness","level":5,"score":0.6141886115074158},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6066399812698364},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5896937251091003},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.5724809765815735},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.5567754507064819},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4955240488052368},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.48860055208206177},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.46913784742355347},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.46775010228157043},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3472660183906555},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34479841589927673},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.21916592121124268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1897643804550171},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.12952697277069092},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.06341373920440674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi48211.2021.9434012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9434012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335790","display_name":"Shenzhen Peacock Plan","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1686810756","https://openalex.org/W1903029394","https://openalex.org/W1998726711","https://openalex.org/W2110119381","https://openalex.org/W2194775991","https://openalex.org/W2618530766","https://openalex.org/W2800012666","https://openalex.org/W2946083210","https://openalex.org/W2964275459","https://openalex.org/W2964350391","https://openalex.org/W6763084374"],"related_works":["https://openalex.org/W2134466152","https://openalex.org/W3029880871","https://openalex.org/W1570549308","https://openalex.org/W4251080314","https://openalex.org/W3038746453","https://openalex.org/W4319080291","https://openalex.org/W3200843925","https://openalex.org/W1990649924","https://openalex.org/W1966142707","https://openalex.org/W1865440126"],"abstract_inverted_index":{"Retinopathy":[0],"of":[1,6,10,17,45,84,140,171],"prematurity":[2],"(ROP)":[3],"is":[4,19,47,59,65,108,126,151,166],"one":[5],"the":[7,25,43,52,57,62,82,85,106,116,130,137,145,169],"commonest":[8],"causes":[9],"acquired":[11],"blindness":[12],"in":[13],"children.":[14],"The":[15,99,148],"stage":[16,41,170],"ROP":[18,26,40,46,138,156],"an":[20,154],"important":[21],"step":[22],"to":[23,51,128],"evaluate":[24],"severity":[27],"for":[28,39,119,168],"disease":[29],"control":[30],"and":[31,61,87,113,143,158],"management.":[32],"However,":[33],"there":[34],"are":[35],"still":[36],"various":[37],"challenges":[38],"since":[42],"pattern":[44],"relatively":[48],"obscure":[49],"compared":[50],"entire":[53],"fundus":[54],"image.":[55],"Also,":[56],"dataset":[58,157],"small":[60,111],"image":[63],"quality":[64],"quite":[66],"poor.":[67],"To":[68],"address":[69],"these":[70,88],"issues,":[71],"we":[72],"develop":[73],"a":[74,94],"multi-instance":[75],"learning":[76],"(MIL)":[77],"network,":[78],"which":[79,133],"can":[80,90,134],"extract":[81],"features":[83,89,139],"images":[86],"be":[91],"enhanced":[92],"by":[93,105],"fully":[95],"convolutional":[96],"network":[97,150],"(FCN).":[98],"spatial":[100],"score":[101],"map":[102],"(SSM)":[103],"produced":[104],"FCN":[107],"cropped":[109],"into":[110,115],"patches":[112],"fed":[114],"proposed":[117,149,164],"MIL":[118,131],"further":[120],"feature":[121],"learning.":[122],"An":[123],"attention":[124],"mechanism":[125],"leveraged":[127],"guide":[129],"pooling,":[132],"focus":[135],"on":[136,153],"different":[141],"stages":[142],"improve":[144],"staging":[146],"results.":[147],"evaluated":[152],"in-house":[155],"experimental":[159],"results":[160],"demonstrate":[161],"that":[162],"our":[163],"method":[165],"promising":[167],"ROP.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}