{"id":"https://openalex.org/W3164505453","doi":"https://doi.org/10.1109/isbi48211.2021.9433832","title":"Interpretable Deep Model For Predicting Gene-Addicted Non-Small-Cell Lung Cancer In Ct Scans","display_name":"Interpretable Deep Model For Predicting Gene-Addicted Non-Small-Cell Lung Cancer In Ct Scans","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3164505453","doi":"https://doi.org/10.1109/isbi48211.2021.9433832","mag":"3164505453"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9433832","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9433832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2318/1790376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078978043","display_name":"Carmelo Pino","orcid":"https://orcid.org/0000-0003-0726-7851"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"C. Pino","raw_affiliation_strings":["PeRCeiVe Lab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"PeRCeiVe Lab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031450889","display_name":"Simone Palazzo","orcid":"https://orcid.org/0000-0002-2441-0982"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Palazzo","raw_affiliation_strings":["PeRCeiVe Lab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"PeRCeiVe Lab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066281190","display_name":"Francesca Trenta","orcid":"https://orcid.org/0000-0003-2524-3837"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Trenta","raw_affiliation_strings":["iCTLab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"iCTLab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064773200","display_name":"Francesca Cordero","orcid":"https://orcid.org/0000-0002-3143-3330"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Cordero","raw_affiliation_strings":["University of Torino, Italy"],"affiliations":[{"raw_affiliation_string":"University of Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030188696","display_name":"Ula\u015f Ba\u011fc\u0131","orcid":"https://orcid.org/0000-0001-7379-6829"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U. Bagci","raw_affiliation_strings":["Center for Research in Computer Vision, University of Central Florida, Orlando, FL, USA"],"affiliations":[{"raw_affiliation_string":"Center for Research in Computer Vision, University of Central Florida, Orlando, FL, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036892535","display_name":"Francesco Rundo","orcid":"https://orcid.org/0000-0003-1766-3065"},"institutions":[{"id":"https://openalex.org/I131827901","display_name":"STMicroelectronics (Switzerland)","ror":"https://ror.org/00wm3b005","country_code":"CH","type":"company","lineage":["https://openalex.org/I131827901"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. Rundo","raw_affiliation_strings":["STMicrolectronics, ADG Central R & D, Catania"],"affiliations":[{"raw_affiliation_string":"STMicrolectronics, ADG Central R & D, Catania","institution_ids":["https://openalex.org/I131827901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042746008","display_name":"Sebastiano Battiato","orcid":"https://orcid.org/0000-0001-6127-2470"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Battiato","raw_affiliation_strings":["PeRCeiVe Lab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"PeRCeiVe Lab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841330","display_name":"Daniela Giordano","orcid":"https://orcid.org/0000-0001-5135-1351"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Giordano","raw_affiliation_strings":["PeRCeiVe Lab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"PeRCeiVe Lab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089092418","display_name":"Marco Aldinucci","orcid":"https://orcid.org/0000-0001-8788-0829"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Aldinucci","raw_affiliation_strings":["University of Torino, Italy"],"affiliations":[{"raw_affiliation_string":"University of Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075815307","display_name":"Concetto Spampinato","orcid":"https://orcid.org/0000-0001-6653-2577"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Spampinato","raw_affiliation_strings":["PeRCeiVe Lab, University of Catania, Italy"],"affiliations":[{"raw_affiliation_string":"PeRCeiVe Lab, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5078978043"],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":null,"apc_paid":null,"fwci":0.5549,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65886673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"891","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8386809229850769},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6369436979293823},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.620103657245636},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6143174171447754},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4887854754924774},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.4342499375343323},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4194231629371643},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40883558988571167},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3217197060585022},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.242925763130188},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1988641321659088},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19674238562583923}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8386809229850769},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6369436979293823},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.620103657245636},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6143174171447754},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4887854754924774},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4342499375343323},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4194231629371643},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40883558988571167},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3217197060585022},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.242925763130188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1988641321659088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19674238562583923}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi48211.2021.9433832","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9433832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.unito.it:2318/1790376","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1790376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:zenodo.org:5120742","is_oa":true,"landing_page_url":"https://zenodo.org/record/5120742","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencePaper"}],"best_oa_location":{"id":"pmh:oai:iris.unito.it:2318/1790376","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1790376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1673923490","https://openalex.org/W1901129140","https://openalex.org/W2118798550","https://openalex.org/W2463818697","https://openalex.org/W2464708700","https://openalex.org/W2559597482","https://openalex.org/W2599293763","https://openalex.org/W2746549795","https://openalex.org/W2752782242","https://openalex.org/W2782896508","https://openalex.org/W2848312316","https://openalex.org/W2907762552","https://openalex.org/W2938499665","https://openalex.org/W2947413545","https://openalex.org/W2963420686","https://openalex.org/W2963446712","https://openalex.org/W2964116600","https://openalex.org/W2964153729","https://openalex.org/W2964253222","https://openalex.org/W2994699487","https://openalex.org/W3025806998","https://openalex.org/W4293846201","https://openalex.org/W6637162671","https://openalex.org/W6639824700","https://openalex.org/W6739868092","https://openalex.org/W6743731764","https://openalex.org/W6755310938","https://openalex.org/W6761279468","https://openalex.org/W6777648452"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4390569940","https://openalex.org/W2888392564","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W1986582023","https://openalex.org/W2966829450","https://openalex.org/W4315864862","https://openalex.org/W4380075502"],"abstract_inverted_index":{"Genetic":[0],"profiling":[1],"and":[2,84,104,125,135,178],"characterization":[3],"of":[4,50,69,146,150,158,174,187],"lung":[5,185],"cancers":[6],"have":[7],"recently":[8],"emerged":[9],"as":[10,86,131],"a":[11,44,61,77,108,132,142,159,171,179],"new":[12],"technique":[13],"for":[14,66,80,98,114],"targeted":[15],"therapeutic":[16],"treatment":[17],"based":[18],"on":[19,167],"immunotherapy":[20],"or":[21,88],"molecular":[22],"drugs.":[23],"However,":[24],"the":[25,67,94,144,156],"most":[26],"effective":[27],"way":[28],"to":[29,42,59,64],"discover":[30],"specific":[31,160],"gene":[32],"mutations":[33],"through":[34,101],"tissue":[35],"biopsy":[36,65],"has":[37,56],"several":[38],"limitations,":[39],"from":[40,53],"invasiveness":[41],"being":[43],"risky":[45],"procedure.":[46],"Recently,":[47],"quantitative":[48],"assessment":[49],"visual":[51],"features":[52],"CT":[54,152],"data":[55],"been":[57],"demonstrated":[58],"be":[60],"valid":[62],"alternative":[63],"diagnosis":[68],"gene-addicted":[70,87],"tumors.":[71],"In":[72],"this":[73,128,168],"paper,":[74],"we":[75],"present":[76],"deep":[78],"model":[79,121,137],"automated":[81],"lesion":[82,115],"segmentation":[83,91,100,172],"classification":[85,180],"not.":[89],"The":[90],"approach":[92,129,166],"extends":[93],"2D":[95],"Tiramisu":[96],"architecture":[97],"3D":[99,110],"dense":[102],"blocks":[103],"squeeze-and-excitation":[105],"layers,":[106],"while":[107],"multi-scale":[109],"CNN":[111],"is":[112],"used":[113],"classification.":[116],"We":[117,139,163],"also":[118,140],"train":[119],"our":[120,165],"with":[122,155],"adversarial":[123],"samples,":[124],"show":[126],"that":[127],"acts":[130],"gradient":[133],"regularizer":[134],"enhances":[136],"interpretability.":[138],"built":[141],"dataset,":[143],"first":[145],"its":[147],"nature,":[148],"consisting":[149],"73":[151],"scans":[153],"annotated":[154],"presence":[157],"genomics":[161],"profile.":[162],"test":[164],"dataset":[169],"achieving":[170],"accuracy":[173,181],"93.11%":[175],"(Dice":[176],"score)":[177],"in":[182],"identifying":[183],"oncogene-addicted":[184],"tumors":[186],"82.00%.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
