{"id":"https://openalex.org/W3165215466","doi":"https://doi.org/10.1109/isbi48211.2021.9433829","title":"Self-Supervised Learning For Detection Of Breast Cancer In Surgical Margins With Limited Data","display_name":"Self-Supervised Learning For Detection Of Breast Cancer In Surgical Margins With Limited Data","publication_year":2021,"publication_date":"2021-04-13","ids":{"openalex":"https://openalex.org/W3165215466","doi":"https://doi.org/10.1109/isbi48211.2021.9433829","mag":"3165215466"},"language":"en","primary_location":{"id":"doi:10.1109/isbi48211.2021.9433829","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9433829","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022874103","display_name":"Alice Santilli","orcid":"https://orcid.org/0000-0001-5206-1727"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Alice M.L. Santilli","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002749573","display_name":"Amoon Jamzad","orcid":"https://orcid.org/0000-0002-0828-4365"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amoon Jamzad","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059498497","display_name":"Alireza Sedghi","orcid":"https://orcid.org/0000-0002-6341-2577"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alireza Sedghi","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101661555","display_name":"Martin Kaufmann","orcid":"https://orcid.org/0000-0003-0163-2205"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin Kaufmann","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078370200","display_name":"Shaila J. Merchant","orcid":"https://orcid.org/0000-0002-8133-7988"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shaila Merchant","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103802569","display_name":"Jay Engel","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jay Engel","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075090998","display_name":"Kathryn Logan","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kathryn Logan","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079682225","display_name":"Julie Wallis","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Wallis","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020076569","display_name":"Natasja Janssen","orcid":"https://orcid.org/0000-0002-1704-1891"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Natasja Janssen","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005188575","display_name":"Sonal Varmak","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonal Varmak","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084753910","display_name":"G\u00e1bor Fichtinger","orcid":"https://orcid.org/0000-0002-6354-262X"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gabor Fichtinger","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108724892","display_name":"John F. Rudan","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John F. Rudan","raw_affiliation_strings":["Queen\u2019s University, Kingston, Canada","Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040401197","display_name":"Parvin Mousavi","orcid":"https://orcid.org/0000-0002-1630-7379"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Parvin Mousavi","raw_affiliation_strings":["School of Computing, Queen\u2019s University, Kingston, Canada","School of Computing, Queen's University, Kingston, Canada"],"affiliations":[{"raw_affiliation_string":"School of Computing, Queen\u2019s University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Kingston, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5022874103"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":null,"apc_paid":null,"fwci":1.6316,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.86416294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"980","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6870958805084229},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6831806898117065},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5894542336463928},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5371902585029602},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"Cancer detection","score":0.47361990809440613},{"id":"https://openalex.org/keywords/shuffling","display_name":"Shuffling","score":0.46196669340133667},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4559498429298401},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4553450047969818},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.364036500453949},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1244862973690033}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6870958805084229},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6831806898117065},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5894542336463928},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5371902585029602},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.47361990809440613},{"id":"https://openalex.org/C167927819","wikidata":"https://www.wikidata.org/wiki/Q1930567","display_name":"Shuffling","level":2,"score":0.46196669340133667},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4559498429298401},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4553450047969818},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.364036500453949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1244862973690033},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi48211.2021.9433829","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi48211.2021.9433829","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1677573439","https://openalex.org/W2139939613","https://openalex.org/W2321533354","https://openalex.org/W2796448929","https://openalex.org/W2898257314","https://openalex.org/W2920684403","https://openalex.org/W2963041308","https://openalex.org/W2963216264","https://openalex.org/W3017517361","https://openalex.org/W6759880871"],"related_works":["https://openalex.org/W4380075502","https://openalex.org/W4223943233","https://openalex.org/W4312200629","https://openalex.org/W4360585206","https://openalex.org/W4364306694","https://openalex.org/W4380086463","https://openalex.org/W4225161397","https://openalex.org/W3014300295","https://openalex.org/W3164822677","https://openalex.org/W2795261237"],"abstract_inverted_index":{"Breast":[0],"conserving":[1],"surgery":[2],"is":[3,39,69,107],"a":[4,40,65,97,178],"standard":[5],"cancer":[6,34,66,91,124,184,205],"treatment":[7],"to":[8,26,63,86,177,195],"resect":[9],"breast":[10,61],"tumors":[11],"while":[12],"preserving":[13],"healthy":[14],"tissue.":[15,56],"The":[16,126,168,186],"reoperation":[17],"rate":[18],"can":[19,45],"be":[20],"as":[21,23],"high":[22],"35%":[24],"due":[25],"the":[27,58,88,110,121,130,136,150,155,160,163,166,172,190],"difficulties":[28],"associated":[29],"with":[30],"detection":[31,67,92],"of":[32,52,55,60,83,90,100,113,117,123,157,165],"remaining":[33],"in":[35,201],"surgical":[36,94],"margins.":[37],"REIMS":[38,118,208],"mass":[41],"spectrometry":[42],"method":[43,188],"that":[44],"address":[46],"this":[47],"challenge":[48],"through":[49],"real-time":[50],"measurement":[51],"molecular":[53],"signature":[54],"However,":[57],"collection":[59],"spectra":[62,137],"train":[64],"model":[68,106,127,161,173],"time":[70],"consuming":[71],"and":[72,141,153,181,193,198,206],"large":[73],"samples":[74],"sizes":[75],"are":[76,174],"not":[77],"practical.":[78],"We":[79],"propose":[80],"an":[81],"application":[82],"self-supervised":[84],"learning":[85,154],"improve":[87],"performance":[89],"at":[93],"margins":[95],"using":[96],"limited":[98],"number":[99],"labelled":[101],"data":[102,119,132,152,202],"samples.":[103,209],"A":[104],"deep":[105],"trained":[108],"for":[109,129,183],"intermediate":[111],"task":[112],"capturing":[114],"latent":[115],"features":[116],"without":[120],"use":[122],"labels.":[125],"compensates":[128],"small":[131],"size":[133],"by":[134],"dividing":[135],"into":[138],"smaller":[139],"patches":[140],"shuffling":[142],"their":[143],"order,":[144],"generating":[145],"new":[146],"instances.":[147],"By":[148],"interrogating":[149],"shuffled":[151],"order":[156],"its":[158],"patches,":[159],"captures":[162],"characteristics":[164],"data.":[167],"learnt":[169],"weights":[170],"from":[171,203],"then":[175],"transferred":[176],"subsequent":[179],"network":[180],"fine-tuned":[182],"detection.":[185],"proposed":[187],"achieved":[189],"accuracy,":[191],"sensitivity":[192],"specificity":[194],"97%,":[196],"91%":[197],"100%,":[199],"respectively,":[200],"144":[204],"normal":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}