{"id":"https://openalex.org/W3026561704","doi":"https://doi.org/10.1109/isbi45749.2020.9098659","title":"Optimizing Particle Detection by Colocalization Analysis in Multi-Channel Fluorescence Microscopy Images","display_name":"Optimizing Particle Detection by Colocalization Analysis in Multi-Channel Fluorescence Microscopy Images","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3026561704","doi":"https://doi.org/10.1109/isbi45749.2020.9098659","mag":"3026561704"},"language":"en","primary_location":{"id":"doi:10.1109/isbi45749.2020.9098659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi45749.2020.9098659","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103224528","display_name":"Christian Ritter","orcid":"https://orcid.org/0000-0002-1720-6983"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"C. Ritter","raw_affiliation_strings":["Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069713371","display_name":"A. Newrly","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Newrly","raw_affiliation_strings":["Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063883507","display_name":"Sandra Schifferdecker","orcid":"https://orcid.org/0000-0003-1473-5748"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Schifferdecker","raw_affiliation_strings":["University Hospital Heidelberg, Im Neuenheimer Feld 344, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"University Hospital Heidelberg, Im Neuenheimer Feld 344, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017113738","display_name":"Imme Roggenbach","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Roggenbach","raw_affiliation_strings":["Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091231669","display_name":"B\u00e1rbara M\u00fcller","orcid":"https://orcid.org/0000-0001-5726-5585"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Muller","raw_affiliation_strings":["University Hospital Heidelberg, Im Neuenheimer Feld 344, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"University Hospital Heidelberg, Im Neuenheimer Feld 344, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105834383","display_name":"K. Rohr","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Rohr","raw_affiliation_strings":["Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Heidelberg University, BioQuant, IPMB, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103224528"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04405912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":null,"first_page":"882","last_page":"885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colocalization","display_name":"Colocalization","score":0.7454535961151123},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.736021101474762},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.6803516149520874},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.5896108746528625},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.553385317325592},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.4923490285873413},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47087156772613525},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4655720889568329},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.4589579701423645},{"id":"https://openalex.org/keywords/chromatic-aberration","display_name":"Chromatic aberration","score":0.43861353397369385},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4323117136955261},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.42234480381011963},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.37153360247612},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34285059571266174},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3247082531452179},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2982354164123535},{"id":"https://openalex.org/keywords/chromatic-scale","display_name":"Chromatic scale","score":0.2056385576725006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14133906364440918},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.07283052802085876}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.7454535961151123},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.736021101474762},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.6803516149520874},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5896108746528625},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.553385317325592},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.4923490285873413},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47087156772613525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4655720889568329},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.4589579701423645},{"id":"https://openalex.org/C87367554","wikidata":"https://www.wikidata.org/wiki/Q1087688","display_name":"Chromatic aberration","level":3,"score":0.43861353397369385},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4323117136955261},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42234480381011963},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.37153360247612},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34285059571266174},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3247082531452179},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2982354164123535},{"id":"https://openalex.org/C196956537","wikidata":"https://www.wikidata.org/wiki/Q202021","display_name":"Chromatic scale","level":2,"score":0.2056385576725006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14133906364440918},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07283052802085876},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi45749.2020.9098659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi45749.2020.9098659","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1497467118","https://openalex.org/W2049360731","https://openalex.org/W2083517198","https://openalex.org/W2105285738","https://openalex.org/W2143623375","https://openalex.org/W2168237413","https://openalex.org/W2769192984","https://openalex.org/W2888107234","https://openalex.org/W2945993058","https://openalex.org/W2949609742","https://openalex.org/W2952007634","https://openalex.org/W2960940172"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W4362562564","https://openalex.org/W4248117623","https://openalex.org/W2894139091","https://openalex.org/W4280496049","https://openalex.org/W2883259687","https://openalex.org/W1637909","https://openalex.org/W2947895456","https://openalex.org/W1983780159"],"abstract_inverted_index":{"Automatic":[0],"detection":[1,42],"of":[2,48,64,99,131],"virus":[3,102],"particles":[4],"displayed":[5],"as":[6,74,91,93,126,128],"small":[7],"spots":[8],"in":[9,43,69],"fluorescence":[10,50],"microscopy":[11,51,97],"images":[12,98],"is":[13,56,60,72],"an":[14],"important":[15],"task":[16],"to":[17,28,114],"elucidate":[18],"infection":[19],"processes.":[20],"Particles":[21],"are":[22],"typically":[23],"labeled":[24,58,66],"with":[25,122],"multiple":[26],"fluorophores":[27],"acquire":[29],"multi-channel":[30],"images.":[31],"We":[32,106],"propose":[33],"a":[34,75,81,115],"new":[35],"weakly":[36],"supervised":[37,117],"approach":[38,85,110],"for":[39,77],"automatic":[40],"particle":[41],"the":[44,132],"lower":[45],"SNR":[46],"channel":[47],"two-channel":[49],"data.":[52],"A":[53],"main":[54],"advantage":[55],"that":[57,108],"data":[59],"not":[61],"required.":[62],"Instead":[63],"using":[65,80,89],"data,":[67],"colocalization":[68],"different":[70],"channels":[71],"exploited":[73],"surrogate":[76],"ground":[78],"truth":[79],"novel":[82],"measure.":[83],"Our":[84],"has":[86],"been":[87],"evaluated":[88],"synthetic":[90],"well":[92,127],"challenging":[94],"live":[95],"cell":[96],"human":[100],"immunodeficiency":[101],"type":[103],"1":[104],"particles.":[105],"found,":[107],"our":[109],"yields":[111],"comparable":[112],"results":[113],"state-of-the-art":[116],"method,":[118],"and":[119],"can":[120],"cope":[121],"defective":[123],"fluorescent":[124],"labeling":[125],"chromatic":[129],"aberration":[130],"microscope.":[133]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
