{"id":"https://openalex.org/W2956746616","doi":"https://doi.org/10.1109/isbi.2019.8759578","title":"Ensemble Of Neural Networks For High Endothelial Venules Detection In Meca-79 Immunohistochemistry Images","display_name":"Ensemble Of Neural Networks For High Endothelial Venules Detection In Meca-79 Immunohistochemistry Images","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2956746616","doi":"https://doi.org/10.1109/isbi.2019.8759578","mag":"2956746616"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759578","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025499692","display_name":"Arnaud Abreu","orcid":"https://orcid.org/0000-0002-7838-1849"},"institutions":[{"id":"https://openalex.org/I4210107416","display_name":"Roche (France)","ror":"https://ror.org/01mqmer16","country_code":"FR","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210107416"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Abreu","raw_affiliation_strings":["Institut Roche, Boulogne-Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Roche, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I4210107416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006236869","display_name":"Camille Franchet","orcid":"https://orcid.org/0000-0002-3214-0142"},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210098740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Franchet","raw_affiliation_strings":["Institut Universitaire du Cancer-Oncopole,, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire du Cancer-Oncopole,, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081462715","display_name":"F-X. Frenois","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210098740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F-X. Frenois","raw_affiliation_strings":["Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052434973","display_name":"Pierre Brousset","orcid":"https://orcid.org/0000-0002-8629-3291"},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210098740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Brousset","raw_affiliation_strings":["Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064398262","display_name":"Jean\u2010Philippe Girard","orcid":"https://orcid.org/0000-0002-9154-1691"},"institutions":[{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. P. Girard","raw_affiliation_strings":["Institut de Pharmacologie et de Biologie Structurale, Toulouse, Midi-Pyr\u00c3\u00a9n\u00c3\u00a9es, FR","Institut de Pharmacologie et de Biologie Structurale, Toulouse, Midi-Pyr\u00e9n\u00e9es, FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie et de Biologie Structurale, Toulouse, Midi-Pyr\u00c3\u00a9n\u00c3\u00a9es, FR","institution_ids":["https://openalex.org/I4210099749"]},{"raw_affiliation_string":"Institut de Pharmacologie et de Biologie Structurale, Toulouse, Midi-Pyr\u00e9n\u00e9es, FR","institution_ids":["https://openalex.org/I4210099749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062244451","display_name":"Patrice Den\u00e8fle","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210098740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Denefle","raw_affiliation_strings":["Department of Pathology, Institut Universitaire du Cancer-Oncop\u00f4le, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institut Universitaire du Cancer-Oncop\u00f4le, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086489846","display_name":"Beno\u00eet Naegel","orcid":"https://orcid.org/0000-0002-7695-1473"},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Naegel","raw_affiliation_strings":["Universit\u00b4e de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00b4e de Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091361238","display_name":"C\u00e9dric Wemmert","orcid":"https://orcid.org/0000-0002-4360-4918"},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Wemmert","raw_affiliation_strings":["Universit\u00b4e de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00b4e de Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1398,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49033555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"938","last_page":"942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunostaining","display_name":"Immunostaining","score":0.7166229486465454},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.6324265003204346},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5916179418563843},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4872828722000122},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45538899302482605},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4380052089691162},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2809141278266907}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7166229486465454},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6324265003204346},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5916179418563843},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4872828722000122},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45538899302482605},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4380052089691162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2809141278266907}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2019.8759578","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:hal-04771691v1","is_oa":false,"landing_page_url":"https://ut3-toulouseinp.hal.science/hal-04771691","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heritage Journal, 2019, pp.938-942. &#x27E8;10.1109/isbi.2019.8759578&#x27E9;","raw_type":"Journal articles"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5299999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321663","display_name":"Association Nationale de la Recherche et de la Technologie","ror":"https://ror.org/00ht2ab73"},{"id":"https://openalex.org/F4320322727","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","ror":"https://ror.org/03sjk9a61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W13924619","https://openalex.org/W1538257125","https://openalex.org/W1998734250","https://openalex.org/W2034750640","https://openalex.org/W2046560134","https://openalex.org/W2061119986","https://openalex.org/W2100128988","https://openalex.org/W2115629999","https://openalex.org/W2128073546","https://openalex.org/W2144012133","https://openalex.org/W2164544703","https://openalex.org/W2164921999","https://openalex.org/W2263854116","https://openalex.org/W2297761292","https://openalex.org/W2515623609","https://openalex.org/W2605792367","https://openalex.org/W2625829651","https://openalex.org/W2788838181","https://openalex.org/W2963173418","https://openalex.org/W2963384892","https://openalex.org/W4293437635","https://openalex.org/W6679154154","https://openalex.org/W6684636516","https://openalex.org/W6697229132","https://openalex.org/W6748173244","https://openalex.org/W6749107692"],"related_works":["https://openalex.org/W2924722371","https://openalex.org/W2512703498","https://openalex.org/W2347823473","https://openalex.org/W1546067550","https://openalex.org/W110523806","https://openalex.org/W2300147703","https://openalex.org/W2056351008","https://openalex.org/W3134667467","https://openalex.org/W4230877472","https://openalex.org/W2042848525"],"abstract_inverted_index":{"The":[0],"presence":[1],"of":[2,74,97],"high":[3,56],"endothelial":[4],"venules":[5],"(HEVs)":[6],"in":[7,17,29,39,44,61,77,113],"the":[8,40,62],"tumor":[9,41,63],"micro-environment":[10],"is":[11,83,120],"associated":[12],"with":[13],"favorable":[14],"clinical":[15],"out-come":[16],"breast":[18],"cancer":[19],"and":[20,49,110,115],"other":[21],"human":[22],"solid":[23],"tumors.":[24],"HEVs":[25,35],"can":[26],"be":[27,53],"highlighted":[28],"tissue":[30],"samples":[31],"by":[32,47],"MECA-79":[33,75,114],"immunohistochemistry.":[34],"are":[36],"heterogeneously":[37],"scattered":[38],"micro-environment,":[42],"preferentially":[43],"areas":[45],"infiltrated":[46],"lymphocytes,":[48],"their":[50],"density":[51],"must":[52],"assessed":[54],"at":[55],"resolution":[57],"on":[58],"whole":[59,78,89],"slide":[60,79,90],"area.":[64],"We":[65],"present":[66],"a":[67,88],"frame-work":[68],"for":[69,93,103],"HEV":[70],"detection":[71],"through":[72],"classification":[73,118],"immunostaining":[76,117],"images.":[80],"A":[81],"classifier":[82],"provided,":[84],"as":[85,87],"well":[86],"image":[91],"metric":[92],"general":[94,116],"performance":[95],"evaluation":[96],"detectors.":[98],"An":[99],"original":[100],"ensemble":[101],"strategy":[102],"convolutional":[104],"neural":[105],"networks":[106],"has":[107],"been":[108],"developed":[109],"its":[111],"relevance":[112],"tasks":[119],"discussed.":[121]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
