{"id":"https://openalex.org/W2959879017","doi":"https://doi.org/10.1109/isbi.2019.8759412","title":"Segmentation And Quantification Of Cellular Load In Pulmonary Endomicroscopic Images Using Convolutional Neural Networks","display_name":"Segmentation And Quantification Of Cellular Load In Pulmonary Endomicroscopic Images Using Convolutional Neural Networks","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2959879017","doi":"https://doi.org/10.1109/isbi.2019.8759412","mag":"2959879017"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759412","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759412","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013042518","display_name":"Savinien Bonheur","orcid":null},"institutions":[{"id":"https://openalex.org/I32062511","display_name":"Heriot-Watt University","ror":"https://ror.org/04mghma93","country_code":"GB","type":"education","lineage":["https://openalex.org/I32062511"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Bonheur","raw_affiliation_strings":["Institute of Sensors, Signals & Systems, Heriot Watt University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sensors, Signals & Systems, Heriot Watt University, UK","institution_ids":["https://openalex.org/I32062511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055467044","display_name":"Ahmed Karam Eldaly","orcid":"https://orcid.org/0000-0002-2266-6992"},"institutions":[{"id":"https://openalex.org/I32062511","display_name":"Heriot-Watt University","ror":"https://ror.org/04mghma93","country_code":"GB","type":"education","lineage":["https://openalex.org/I32062511"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.K. Eldaly","raw_affiliation_strings":["Institute of Sensors, Signals & Systems, Heriot Watt University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sensors, Signals & Systems, Heriot Watt University, UK","institution_ids":["https://openalex.org/I32062511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080539408","display_name":"Jody Westerfeld","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138333","display_name":"Community Health Network","ror":"https://ror.org/040cn9093","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138333"]},{"id":"https://openalex.org/I4210158169","display_name":"Community Hospital","ror":"https://ror.org/04z5qk104","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210158169"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Westerfeld","raw_affiliation_strings":["Community Health Network, Community Hospital South, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Community Health Network, Community Hospital South, Indianapolis, USA","institution_ids":["https://openalex.org/I4210138333","https://openalex.org/I4210158169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019567819","display_name":"David Wilson","orcid":"https://orcid.org/0000-0001-8372-3041"},"institutions":[{"id":"https://openalex.org/I4210138333","display_name":"Community Health Network","ror":"https://ror.org/040cn9093","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138333"]},{"id":"https://openalex.org/I4210158169","display_name":"Community Hospital","ror":"https://ror.org/04z5qk104","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210158169"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Wilson","raw_affiliation_strings":["Community Health Network, Community Hospital South, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Community Health Network, Community Hospital South, Indianapolis, USA","institution_ids":["https://openalex.org/I4210138333","https://openalex.org/I4210158169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053576296","display_name":"Kevin Dhaliwal","orcid":"https://orcid.org/0000-0002-3925-3174"},"institutions":[{"id":"https://openalex.org/I1299528221","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842","country_code":"GB","type":"government","lineage":["https://openalex.org/I1299528221","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4210151647","display_name":"Centre for Inflammation Research","ror":"https://ror.org/05wcr1b38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210151647","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Dhaliwal","raw_affiliation_strings":["EPSRC Proteus IRC Hub, Centre for Inflammation Research, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPSRC Proteus IRC Hub, Centre for Inflammation Research, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210151647","https://openalex.org/I1299528221","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010538525","display_name":"Stephen McLaughlin","orcid":"https://orcid.org/0000-0002-9558-8294"},"institutions":[{"id":"https://openalex.org/I32062511","display_name":"Heriot-Watt University","ror":"https://ror.org/04mghma93","country_code":"GB","type":"education","lineage":["https://openalex.org/I32062511"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. McLaughlin","raw_affiliation_strings":["Institute of Sensors, Signals & Systems, Heriot Watt University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sensors, Signals & Systems, Heriot Watt University, UK","institution_ids":["https://openalex.org/I32062511"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031813365","display_name":"Antonios Perperidis","orcid":"https://orcid.org/0000-0001-9010-9656"},"institutions":[{"id":"https://openalex.org/I32062511","display_name":"Heriot-Watt University","ror":"https://ror.org/04mghma93","country_code":"GB","type":"education","lineage":["https://openalex.org/I32062511"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Perperidis","raw_affiliation_strings":["Institute of Sensors, Signals & Systems, Heriot Watt University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sensors, Signals & Systems, Heriot Watt University, UK","institution_ids":["https://openalex.org/I32062511"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"1018","last_page":"1022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9629999995231628,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.8229260444641113},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6971797943115234},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6777114868164062},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6475350856781006},{"id":"https://openalex.org/keywords/endomicroscopy","display_name":"Endomicroscopy","score":0.5993103981018066},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5077565908432007},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.47651803493499756},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.43671587109565735},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.4259808659553528},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.36438629031181335},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.2101142406463623},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0787363052368164}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.8229260444641113},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6971797943115234},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6777114868164062},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6475350856781006},{"id":"https://openalex.org/C17480853","wikidata":"https://www.wikidata.org/wiki/Q5376368","display_name":"Endomicroscopy","level":3,"score":0.5993103981018066},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5077565908432007},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.47651803493499756},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.43671587109565735},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.4259808659553528},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.36438629031181335},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.2101142406463623},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0787363052368164},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2019.8759412","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759412","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4554086864","display_name":null,"funder_award_id":"EP/K03197X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W6908809","https://openalex.org/W1533861849","https://openalex.org/W1677182931","https://openalex.org/W1800499965","https://openalex.org/W1901129140","https://openalex.org/W1977330664","https://openalex.org/W2058501113","https://openalex.org/W2064978616","https://openalex.org/W2072880652","https://openalex.org/W2097681247","https://openalex.org/W2155893237","https://openalex.org/W2194775991","https://openalex.org/W2345215099","https://openalex.org/W2407631332","https://openalex.org/W2592888171","https://openalex.org/W2606795859","https://openalex.org/W2614162590","https://openalex.org/W2783328077","https://openalex.org/W2806641269","https://openalex.org/W2888438507","https://openalex.org/W2997720601","https://openalex.org/W3140502469","https://openalex.org/W4293406525","https://openalex.org/W6600284362","https://openalex.org/W6631943919","https://openalex.org/W6639824700","https://openalex.org/W6687483927","https://openalex.org/W6717372056","https://openalex.org/W6736227004","https://openalex.org/W6772147550"],"related_works":["https://openalex.org/W3093776189","https://openalex.org/W2085523657","https://openalex.org/W4248767102","https://openalex.org/W2788050109","https://openalex.org/W4353062772","https://openalex.org/W2071932035","https://openalex.org/W2158105767","https://openalex.org/W2997720601","https://openalex.org/W1966436269","https://openalex.org/W2087851706"],"abstract_inverted_index":{"Fibre":[0],"Bundle":[1],"Endomicroscopy":[2],"(FBE\u03bc)":[3],"is":[4,103],"an":[5],"emerging":[6],"tool":[7],"that":[8,91],"facilitates":[9],"the":[10,20,121],"real-time":[11],"structural":[12],"and":[13,45,79,116],"functional":[14],"(via":[15],"fluorescent":[16],"dyes)":[17],"imaging":[18],"of":[19,94,100,114,127],"distal":[21,49],"lung,":[22,50],"providing":[23],"valuable":[24],"in":[25,27,48],"vivo,":[26],"situ":[28],"indicators":[29],"across":[30],"a":[31,40,71,82,111,117],"range":[32],"pathological":[33],"or":[34],"physiological":[35],"processes.":[36],"This":[37],"paper":[38],"proposes":[39],"novel":[41],"approach":[42],"for":[43,75,85],"localising":[44],"quantifying":[46],"abnormalities":[47],"such":[51],"as":[52,96,98],"increased":[53],"cellular":[54,101,124],"load,":[55],"through":[56],"semantic":[57,92],"image":[58,77],"segmentation.":[59],"Two":[60],"Convolutional":[61],"Neural":[62],"Network":[63],"(CNN)":[64],"architectures":[65],"have":[66],"been":[67],"tested,":[68],"(i)":[69],"U-Net,":[70],"purpose":[72],"specific":[73],"network":[74,83],"biomedical":[76],"applications,":[78],"(ii)":[80],"ENet,":[81,109],"optimised":[84],"fast":[86],"inference.":[87],"The":[88],"results":[89],"indicate":[90],"segmentation":[93],"cells":[95],"well":[97],"quantification":[99],"load":[102,125],"viable,":[104],"with":[105,120],"U-Net":[106],"consistently":[107],"outperforming":[108],"obtaining":[110],"pixel":[112],"accuracy":[113],"0.842":[115],"correlation":[118],"(r)":[119],"corresponding":[122],"manual":[123],"estimation":[126],"0.":[128],"866.":[129]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}