{"id":"https://openalex.org/W2963618258","doi":"https://doi.org/10.1109/isbi.2019.8759333","title":"Deconvolving Convolutional Neural Network for Cell Detection","display_name":"Deconvolving Convolutional Neural Network for Cell Detection","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2963618258","doi":"https://doi.org/10.1109/isbi.2019.8759333","mag":"2963618258"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759333","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759333","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://discovery.ucl.ac.uk/10083708/1/1806.06970v1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041645982","display_name":"Shan E Ahmed Raza","orcid":"https://orcid.org/0000-0002-1097-1738"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shan E Ahmed Raza","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043284368","display_name":"Khalid AbdulJabbar","orcid":"https://orcid.org/0000-0002-4411-4435"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Khalid AbdulJabbar","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049902199","display_name":"Mariam Jamal\u2010Hanjani","orcid":"https://orcid.org/0000-0003-1212-1259"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210088881","display_name":"London Cancer","ror":"https://ror.org/005kpb876","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210088881"]},{"id":"https://openalex.org/I4210147892","display_name":"CRUK Lung Cancer Centre of Excellence","ror":"https://ror.org/04nm2mq63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210147892"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mariam Jamal-Hanjani","raw_affiliation_strings":["Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210088881","https://openalex.org/I4210147892","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055872206","display_name":"Selvaraju Veeriah","orcid":"https://orcid.org/0000-0002-1217-0387"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210088881","display_name":"London Cancer","ror":"https://ror.org/005kpb876","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210088881"]},{"id":"https://openalex.org/I4210147892","display_name":"CRUK Lung Cancer Centre of Excellence","ror":"https://ror.org/04nm2mq63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210147892"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Selvaraju Veeriah","raw_affiliation_strings":["Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210088881","https://openalex.org/I4210147892","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057913884","display_name":"John Le Quesne","orcid":"https://orcid.org/0000-0003-3552-7446"},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Le Quesne","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016475369","display_name":"Charles Swanton","orcid":"https://orcid.org/0000-0002-4299-3018"},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles Swanton","raw_affiliation_strings":["The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011555338","display_name":"Yinyin Yuan","orcid":"https://orcid.org/0000-0002-8556-4707"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yinyin Yuan","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1869,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.91351303,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"891","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7452182769775391},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7258448600769043},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7062448263168335},{"id":"https://openalex.org/keywords/convolution","display_name":"Convolution (computer science)","score":0.6349583268165588},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6293008327484131},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.5479743480682373},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.5261219143867493},{"id":"https://openalex.org/keywords/maxima-and-minima","display_name":"Maxima and minima","score":0.4626975655555725},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.36067309975624084},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3484489619731903},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2307921051979065}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7452182769775391},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7258448600769043},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7062448263168335},{"id":"https://openalex.org/C45347329","wikidata":"https://www.wikidata.org/wiki/Q5166604","display_name":"Convolution (computer science)","level":3,"score":0.6349583268165588},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6293008327484131},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.5479743480682373},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.5261219143867493},{"id":"https://openalex.org/C186633575","wikidata":"https://www.wikidata.org/wiki/Q845060","display_name":"Maxima and minima","level":2,"score":0.4626975655555725},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.36067309975624084},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3484489619731903},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2307921051979065},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2019.8759333","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759333","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10083708","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10083708/","pdf_url":"https://discovery.ucl.ac.uk/10083708/1/1806.06970v1.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). (pp. pp. 891-894). IEEE: Venice, Italy,. (2019)","raw_type":"Proceedings paper"}],"best_oa_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10083708","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10083708/","pdf_url":"https://discovery.ucl.ac.uk/10083708/1/1806.06970v1.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). (pp. pp. 891-894). IEEE: Venice, Italy,. (2019)","raw_type":"Proceedings paper"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320279","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963618258.pdf"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W22040386","https://openalex.org/W1901129140","https://openalex.org/W2125188192","https://openalex.org/W2155832181","https://openalex.org/W2312404985","https://openalex.org/W2347064614","https://openalex.org/W2422982059","https://openalex.org/W2426151263","https://openalex.org/W2438635651","https://openalex.org/W2592929672","https://openalex.org/W2738582428","https://openalex.org/W2744785641","https://openalex.org/W2788240710","https://openalex.org/W2798643036","https://openalex.org/W2830786177","https://openalex.org/W6717491880"],"related_works":["https://openalex.org/W2375684291","https://openalex.org/W2354676191","https://openalex.org/W3188646203","https://openalex.org/W136674370","https://openalex.org/W2909957174","https://openalex.org/W2105527480","https://openalex.org/W4320035781","https://openalex.org/W2052387497","https://openalex.org/W2964954556","https://openalex.org/W3019910406"],"abstract_inverted_index":{"Automatic":[0],"cell":[1,41,57,117,128],"detection":[2,44,129],"in":[3],"histology":[4],"images":[5],"is":[6,79,93,111],"a":[7,40,50,66],"challenging":[8],"task":[9],"due":[10],"to":[11,36,55,69,81,100,113,152],"varying":[12],"size,":[13],"shape":[14],"and":[15,19],"features":[16],"of":[17,32,39,45,107],"cells":[18],"stain":[20],"variations":[21],"across":[22],"large":[23],"cohorts.":[24],"Conventional":[25],"deep":[26],"learning":[27],"methods":[28],"regress":[29],"the":[30,37,86,98,108,139,147],"probability":[31,103,131],"each":[33],"pixel":[34],"belonging":[35],"centre":[38],"followed":[42],"by":[43,145],"local":[46,124],"maxima.":[47],"We":[48],"propose":[49],"three":[51],"stage":[52],"method":[53],"(MapDe)":[54],"improve":[56],"detection.":[58,118],"(a)":[59],"The":[60,90,119],"dot":[61],"annotations":[62],"are":[63],"convolved":[64],"with":[65,85,130,149],"mapping":[67,88,91],"filter":[68,92],"generate":[70,101,114],"artificial":[71],"labels.":[72],"(b)":[73],"A":[74],"convolutional":[75],"neural":[76],"network":[77,99],"(CNN)":[78],"modified":[80],"convolve":[82],"its":[83],"output":[84,148],"same":[87],"filter.":[89],"fixed":[94,135],"during":[95],"training":[96],"forcing":[97],"better":[102,127],"maps.":[104],"(c)":[105],"Output":[106],"trained":[109],"CNN":[110],"deconvolved":[112],"points":[115],"as":[116],"results":[120,140],"show":[121],"that":[122],"(1)":[123],"maxima":[125],"performs":[126],"maps":[132],"generated":[133],"using":[134],"convolution":[136],"filter,":[137],"(2)":[138],"can":[141],"be":[142],"further":[143],"improved":[144],"deconvolving":[146],"fewer":[150],"parameters":[151],"tune.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}