{"id":"https://openalex.org/W2961661279","doi":"https://doi.org/10.1109/isbi.2019.8759313","title":"Predictive and discriminative localization of IDH genotype in high grade gliomas using deep convolutional neural nets","display_name":"Predictive and discriminative localization of IDH genotype in high grade gliomas using deep convolutional neural nets","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2961661279","doi":"https://doi.org/10.1109/isbi.2019.8759313","mag":"2961661279"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759313","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759313","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071968514","display_name":"Adnan Ahmad","orcid":"https://orcid.org/0009-0004-8441-3597"},"institutions":[{"id":"https://openalex.org/I244572783","display_name":"Symbiosis International University","ror":"https://ror.org/005r2ww51","country_code":"IN","type":"education","lineage":["https://openalex.org/I244572783"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Adnan Ahmad","raw_affiliation_strings":["Symbiosis Center for Medical Image Analysis, Lavale, Mulshi, Pune, India"],"affiliations":[{"raw_affiliation_string":"Symbiosis Center for Medical Image Analysis, Lavale, Mulshi, Pune, India","institution_ids":["https://openalex.org/I244572783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090068402","display_name":"Srinjay Sarkar","orcid":null},"institutions":[{"id":"https://openalex.org/I244572783","display_name":"Symbiosis International University","ror":"https://ror.org/005r2ww51","country_code":"IN","type":"education","lineage":["https://openalex.org/I244572783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srinjay Sarkar","raw_affiliation_strings":["Symbiosis Center for Medical Image Analysis, Lavale, Mulshi, Pune, India"],"affiliations":[{"raw_affiliation_string":"Symbiosis Center for Medical Image Analysis, Lavale, Mulshi, Pune, India","institution_ids":["https://openalex.org/I244572783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101485008","display_name":"Apurva Shah","orcid":"https://orcid.org/0000-0002-5928-6221"},"institutions":[{"id":"https://openalex.org/I244572783","display_name":"Symbiosis International University","ror":"https://ror.org/005r2ww51","country_code":"IN","type":"education","lineage":["https://openalex.org/I244572783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apurva Shah","raw_affiliation_strings":["Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India"],"affiliations":[{"raw_affiliation_string":"Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India","institution_ids":["https://openalex.org/I244572783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022913482","display_name":"Sonal Gore","orcid":"https://orcid.org/0000-0002-6965-7209"},"institutions":[{"id":"https://openalex.org/I244572783","display_name":"Symbiosis International University","ror":"https://ror.org/005r2ww51","country_code":"IN","type":"education","lineage":["https://openalex.org/I244572783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sonal Gore","raw_affiliation_strings":["Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India"],"affiliations":[{"raw_affiliation_string":"Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India","institution_ids":["https://openalex.org/I244572783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048783285","display_name":"Vani Santosh","orcid":"https://orcid.org/0000-0001-8724-2034"},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vani Santosh","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031198537","display_name":"Jitender Saini","orcid":"https://orcid.org/0000-0002-5218-0264"},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jitender Saini","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089934475","display_name":"Madhura Ingalhalikar","orcid":"https://orcid.org/0000-0002-4809-8559"},"institutions":[{"id":"https://openalex.org/I244572783","display_name":"Symbiosis International University","ror":"https://ror.org/005r2ww51","country_code":"IN","type":"education","lineage":["https://openalex.org/I244572783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhura Ingalhalikar","raw_affiliation_strings":["Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India"],"affiliations":[{"raw_affiliation_string":"Symbiosis Institute of Technology. Symbiosis International (Deemed University), Lavale, Mulshi, Pune, India","institution_ids":["https://openalex.org/I244572783"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5071968514"],"corresponding_institution_ids":["https://openalex.org/I244572783"],"apc_list":null,"apc_paid":null,"fwci":1.2851,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.80761788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"372","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.9010435342788696},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.8235912919044495},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7426344752311707},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6794890761375427},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5920134782791138},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5919655561447144},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.565866231918335},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.43217384815216064},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.19488966464996338},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13596031069755554},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.05401068925857544}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.9010435342788696},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.8235912919044495},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7426344752311707},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6794890761375427},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5920134782791138},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5919655561447144},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.565866231918335},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.43217384815216064},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.19488966464996338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13596031069755554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05401068925857544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2019.8759313","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759313","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1686810756","https://openalex.org/W2104669585","https://openalex.org/W2163605009","https://openalex.org/W2194775991","https://openalex.org/W2295107390","https://openalex.org/W2301066876","https://openalex.org/W2460918282","https://openalex.org/W2528946299","https://openalex.org/W2550744713","https://openalex.org/W2614549267","https://openalex.org/W2734369741","https://openalex.org/W2743501370","https://openalex.org/W2770261599","https://openalex.org/W6637373629","https://openalex.org/W6684191040"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4312407344","https://openalex.org/W2894289927"],"abstract_inverted_index":{"Radiomics":[0],"and":[1,29,73,137],"state-of-art":[2],"convolutional":[3],"neural":[4],"networks":[5],"(CNNs)":[6],"have":[7],"demonstrated":[8],"their":[9],"usefulness":[10],"for":[11,134],"predicting":[12],"genotype":[13],"in":[14,102,113,141],"gliomas":[15],"from":[16],"brain":[17],"MRI":[18,68],"images.":[19],"However,":[20],"these":[21,45],"techniques":[22],"rely":[23],"heavily":[24],"on":[25,63],"accurate":[26],"tumor":[27,75,84],"segmentation":[28,85],"do":[30],"not":[31,79],"facilitate":[32],"any":[33],"insights":[34],"into":[35],"the":[36,95,107,117],"working":[37],"of":[38,70,83,90],"CNN":[39],"to":[40],"understand":[41],"what":[42],"areas":[43],"distinguish":[44],"classes.":[46],"To":[47],"mitigate":[48],"this,":[49],"we":[50],"employ":[51],"a":[52,64],"novel":[53],"technique":[54,78],"called":[55],"Convolutional":[56],"Neural":[57],"Nets":[58],"with":[59,86],"discriminative":[60,97],"localization":[61],"(DL-CNN)":[62],"clinical":[65,135],"T2":[66],"weighted":[67],"dataset":[69],"IDH1":[71,104,115],"mutant":[72],"wild-type":[74],"patients.":[76],"The":[77],"only":[80,106],"is":[81,110,120,131],"free":[82],"high":[87],"classification":[88],"accuracy":[89],"86.7%":[91],"but":[92],"also":[93,121],"locates":[94],"most":[96],"regions.":[98],"We":[99],"demonstrate":[100],"that":[101,130],"majority":[103,114],"mutants":[105],"tumoral":[108],"area":[109],"significant":[111],"while":[112],"wildtype":[116],"peri-tumoral":[118],"edema":[119],"involved.":[122],"Overall,":[123],"our":[124],"method":[125],"besides":[126],"prediction":[127],"provides":[128],"information":[129],"particularly":[132],"important":[133],"interpretability":[136],"can":[138],"be":[139],"used":[140],"targeted":[142],"therapy.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}