{"id":"https://openalex.org/W2961329169","doi":"https://doi.org/10.1109/isbi.2019.8759290","title":"Weakly Supervised Learning in Deformable EM Image Registration Using Slice Interpolation","display_name":"Weakly Supervised Learning in Deformable EM Image Registration Using Slice Interpolation","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2961329169","doi":"https://doi.org/10.1109/isbi.2019.8759290","mag":"2961329169"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759290","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759290","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034729573","display_name":"Thanh Nguyen-Duc","orcid":"https://orcid.org/0000-0001-5764-0998"},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Thanh Nguyen-Duc","raw_affiliation_strings":["Ulsan National Institute of Science and Technology"],"affiliations":[{"raw_affiliation_string":"Ulsan National Institute of Science and Technology","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072405401","display_name":"Inwan Yoo","orcid":null},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inwan Yoo","raw_affiliation_strings":["Ulsan National Institute of Science and Technology"],"affiliations":[{"raw_affiliation_string":"Ulsan National Institute of Science and Technology","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027404634","display_name":"Logan A. Thomas","orcid":"https://orcid.org/0000-0002-7806-3496"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan Thomas","raw_affiliation_strings":["Harvard Medical School"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021305762","display_name":"Aaron T. Kuan","orcid":"https://orcid.org/0000-0002-1908-7949"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Kuan","raw_affiliation_strings":["Harvard Medical School"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090392376","display_name":"Wei-Chung Allen Lee","orcid":"https://orcid.org/0000-0002-4618-295X"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-chung Lee","raw_affiliation_strings":["Harvard Medical School"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025485089","display_name":"Won\u2010Ki Jeong","orcid":"https://orcid.org/0000-0002-9393-6451"},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won-Ki Jeong","raw_affiliation_strings":["Ulsan National Institute of Science and Technology"],"affiliations":[{"raw_affiliation_string":"Ulsan National Institute of Science and Technology","institution_ids":["https://openalex.org/I48566637"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034729573"],"corresponding_institution_ids":["https://openalex.org/I48566637"],"apc_list":null,"apc_paid":null,"fwci":2.4502,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91155492,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"670","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7577896118164062},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.754066526889801},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.7220738530158997},{"id":"https://openalex.org/keywords/interpolation","display_name":"Interpolation (computer graphics)","score":0.6927140355110168},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5224732160568237},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4739672839641571},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4476836025714874},{"id":"https://openalex.org/keywords/connectomics","display_name":"Connectomics","score":0.44318124651908875},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.443070650100708},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.41781166195869446},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.41206613183021545},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.4085991382598877},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.18332058191299438}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7577896118164062},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.754066526889801},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.7220738530158997},{"id":"https://openalex.org/C137800194","wikidata":"https://www.wikidata.org/wiki/Q11713455","display_name":"Interpolation (computer graphics)","level":3,"score":0.6927140355110168},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5224732160568237},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4739672839641571},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4476836025714874},{"id":"https://openalex.org/C2779097318","wikidata":"https://www.wikidata.org/wiki/Q2993446","display_name":"Connectomics","level":4,"score":0.44318124651908875},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.443070650100708},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.41781166195869446},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.41206613183021545},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.4085991382598877},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.18332058191299438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2019.8759290","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759290","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},{"id":"pmh:oai:scholarworks.unist.ac.kr:201301/33766","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/document/8759290","pdf_url":null,"source":{"id":"https://openalex.org/S4306401118","display_name":"Scholarworks@UNIST (Ulsan National Institute of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I48566637","host_organization_name":"Ulsan National Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I48566637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"CONFERENCE"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W764651262","https://openalex.org/W1901129140","https://openalex.org/W2026140461","https://openalex.org/W2176412452","https://openalex.org/W2309258625","https://openalex.org/W2344270078","https://openalex.org/W2608822622","https://openalex.org/W2738479063","https://openalex.org/W2751297520","https://openalex.org/W2963285578","https://openalex.org/W3104028519","https://openalex.org/W6639824700","https://openalex.org/W6685562342"],"related_works":["https://openalex.org/W2212379672","https://openalex.org/W2424680827","https://openalex.org/W2807503652","https://openalex.org/W2079675757","https://openalex.org/W2912524409","https://openalex.org/W2532575085","https://openalex.org/W4251316676","https://openalex.org/W4323066529","https://openalex.org/W4242108457","https://openalex.org/W4246848408"],"abstract_inverted_index":{"Alignment":[0],"of":[1,37,43,88,162],"large-scale":[2,25],"serial-section":[3],"electron":[4],"microscopy":[5],"(ssEM)":[6],"images":[7,112,125],"is":[8],"crucial":[9],"for":[10,85,142],"successful":[11],"analysis":[12],"in":[13,22,47,54,72,154],"nano-scale":[14],"connectomics.":[15],"Despite":[16],"various":[17],"image":[18,49,97],"registration":[19,50,87,98,123],"algorithms":[20],"proposed":[21,116,135],"the":[23,32,38,41,70,86,134,144,148,160,163],"past,":[24],"ssEM":[26,74,111,167],"alignment":[27],"remains":[28],"challenging":[29],"due":[30],"to":[31,56,79,109,121],"size":[33],"and":[34,128],"complex":[35],"nature":[36],"data.":[39],"Recently,":[40],"application":[42],"unsupervised":[44,156],"machine":[45],"learning":[46,104],"medical":[48],"has":[51],"shown":[52],"promise":[53],"efforts":[55],"replace":[57],"an":[58,155],"expensive":[59],"numerical":[60],"computation":[61],"process":[62],"with":[63,126],"a":[64,94],"once-deployed":[65],"feed-forward":[66],"neural":[67],"network.":[68],"However,":[69],"anisotropy":[71],"most":[73],"data":[75,141],"makes":[76],"it":[77],"difficult":[78],"directly":[80],"adopt":[81],"such":[82],"learning-based":[83],"methods":[84],"these":[89],"images.":[90],"Here,":[91],"we":[92],"propose":[93],"novel":[95],"deformable":[96],"approach":[99],"based":[100],"on":[101,165],"weakly":[102],"supervised":[103],"that":[105],"can":[106,151],"be":[107,152],"applied":[108],"registering":[110],"at":[113],"scale.":[114],"The":[115],"method":[117,136,164],"leverages":[118],"slice":[119],"interpolation":[120,145],"improve":[122],"between":[124],"sudden":[127],"large":[129],"structural":[130],"changes.":[131],"In":[132],"addition,":[133],"only":[137],"requires":[138],"roughly":[139],"aligned":[140],"training":[143],"network":[146,150],"while":[147],"deformation":[149],"trained":[153],"fashion.":[157],"We":[158],"demonstrate":[159],"efficacy":[161],"real":[166],"datasets.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2019-07-23T00:00:00"}