{"id":"https://openalex.org/W2956889026","doi":"https://doi.org/10.1109/isbi.2019.8759211","title":"Characterizing White Matter Connectivity in Alzheimer\u2019s Disease and Mild Cognitive Impairment: Automated Fiber Quantification","display_name":"Characterizing White Matter Connectivity in Alzheimer\u2019s Disease and Mild Cognitive Impairment: Automated Fiber Quantification","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2956889026","doi":"https://doi.org/10.1109/isbi.2019.8759211","mag":"2956889026"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759211","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025002700","display_name":"Xuejiao Dou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Dou","raw_affiliation_strings":["School of Artificial Intelligence, University of Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072017748","display_name":"Hongxiang Yao","orcid":"https://orcid.org/0000-0003-1207-2215"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxiang Yao","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101057681","display_name":"Dan Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Jin","raw_affiliation_strings":["School of Artificial Intelligence, University of Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459231","display_name":"Feng Feng","orcid":"https://orcid.org/0000-0002-3507-1154"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Feng","raw_affiliation_strings":["Department of Neurology, The General Hospital of the PLA Rocket Force, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The General Hospital of the PLA Rocket Force, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009579767","display_name":"Pan Wang","orcid":"https://orcid.org/0000-0003-0802-0842"},"institutions":[{"id":"https://openalex.org/I4210102371","display_name":"Tianjin Huanhu Hospital","ror":"https://ror.org/00q6wbs64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102371"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Wang","raw_affiliation_strings":["Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210102371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052590429","display_name":"Bo Zhou","orcid":"https://orcid.org/0000-0002-7973-1185"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Zhou","raw_affiliation_strings":["Department of Neurology, Nanlou Division, Chinese PLA General Hospital; National Clinical Research Center for Geriatric Diseases, Beijing, China","Department of Neurology, Nanlou Division, Chinese PLA General Hospital","National Clinical Research Center for Geriatric Diseases, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanlou Division, Chinese PLA General Hospital; National Clinical Research Center for Geriatric Diseases, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Neurology, Nanlou Division, Chinese PLA General Hospital","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Diseases, Beijing, China","institution_ids":["https://openalex.org/I4210089514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109831307","display_name":"Bing Liu","orcid":"https://orcid.org/0000-0003-2029-5187"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Liu","raw_affiliation_strings":["School of Artificial Intelligence, University of Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101530290","display_name":"Zhengyi Yang","orcid":"https://orcid.org/0000-0002-7819-439X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengyi Yang","raw_affiliation_strings":["Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation,Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation,Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100511597","display_name":"Ningyu An","orcid":null},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningyu An","raw_affiliation_strings":["Department of Radiology, Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430863","display_name":"Xi Zhang","orcid":"https://orcid.org/0000-0003-0032-6636"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":["Department of Neurology, Nanlou Division, Chinese PLA General Hospital; National Clinical Research Center for Geriatric Diseases, Beijing, China","Department of Neurology, Nanlou Division, Chinese PLA General Hospital","National Clinical Research Center for Geriatric Diseases, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanlou Division, Chinese PLA General Hospital; National Clinical Research Center for Geriatric Diseases, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Neurology, Nanlou Division, Chinese PLA General Hospital","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Diseases, Beijing, China","institution_ids":["https://openalex.org/I4210089514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100659487","display_name":"Yong Liu","orcid":"https://orcid.org/0000-0002-1862-3121"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Liu","raw_affiliation_strings":["School of Artificial Intelligence, University of Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2977,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54915704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":null,"first_page":"117","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.7191773653030396},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.6819019913673401},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5014102458953857},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40828460454940796},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.37899091839790344},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.3725094497203827},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32712459564208984},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2637519836425781},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15571993589401245},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.14526742696762085}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7191773653030396},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6819019913673401},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5014102458953857},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40828460454940796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37899091839790344},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3725094497203827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32712459564208984},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2637519836425781},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15571993589401245},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.14526742696762085},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2019.8759211","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1544117304","https://openalex.org/W1964802316","https://openalex.org/W1965842072","https://openalex.org/W1969048570","https://openalex.org/W1991755427","https://openalex.org/W2022699543","https://openalex.org/W2029132563","https://openalex.org/W2031030159","https://openalex.org/W2043260630","https://openalex.org/W2048681279","https://openalex.org/W2106003398","https://openalex.org/W2106763716","https://openalex.org/W2110579639","https://openalex.org/W2110798659","https://openalex.org/W2128776571","https://openalex.org/W2132387058","https://openalex.org/W2137538651","https://openalex.org/W2146048843","https://openalex.org/W2148230634","https://openalex.org/W2150667092","https://openalex.org/W2158567814","https://openalex.org/W2167518249","https://openalex.org/W2170480020","https://openalex.org/W2413280148","https://openalex.org/W2461377883","https://openalex.org/W2496219973","https://openalex.org/W2559664870","https://openalex.org/W2770704336","https://openalex.org/W2781581970","https://openalex.org/W2796958728","https://openalex.org/W2889691470"],"related_works":["https://openalex.org/W2028814883","https://openalex.org/W4253144767","https://openalex.org/W4388887794","https://openalex.org/W2095446662","https://openalex.org/W2131223134","https://openalex.org/W2363580846","https://openalex.org/W4213374733","https://openalex.org/W3036295981","https://openalex.org/W3149433259","https://openalex.org/W1967646248"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,6],"(AD)":[2],"is":[3,32,59],"a":[4,33,69],"neurodegenerative":[5],"characterized":[7],"by":[8],"progressive":[9],"dementia.":[10],"Diffusion":[11],"tensor":[12,92],"imaging":[13,93],"(DTI)":[14],"has":[15],"been":[16],"used":[17],"widely":[18],"to":[19,60,101],"delineate":[20],"the":[21,40,49,62,88,103],"white":[22,42,50,63,96],"matter":[23,43,51,64,97],"integrity/degeneration":[24],"in":[25,68,131],"AD.":[26,132],"Automated":[27],"fiber":[28,44],"quantification":[29],"(AFQ)":[30],"method":[31],"fully":[34],"automated":[35],"method,":[36],"which":[37],"can":[38],"identify":[39],"major":[41],"tracts":[45,98],"and":[46,66,77,119],"then":[47],"evaluate":[48],"properties.":[52],"The":[53,111],"main":[54],"purpose":[55],"of":[56,71,90],"this":[57],"study":[58],"assess":[61],"integrity":[65],"abnormities":[67],"cohort":[70],"amnestic":[72],"Mild":[73],"Cognitive":[74],"Impairment":[75],"(aMCI)":[76],"AD":[78,104],"patients":[79],"as":[80,82,99],"well":[81],"normal":[83],"controls":[84],"(NCs).":[85],"We":[86],"tested":[87],"utility":[89],"diffusion":[91],"measures":[94],"along":[95],"features":[100],"classify":[102],"from":[105],"NCs":[106],"using":[107],"support":[108],"vector":[109],"machine.":[110],"results":[112],"showed":[113],"that":[114,124],"we":[115],"have":[116],"detected":[117],"credible":[118],"robust":[120],"potential":[121],"early":[122],"biomarker":[123],"may":[125],"be":[126],"useful":[127],"for":[128],"clinical":[129],"application":[130]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}