{"id":"https://openalex.org/W2961895065","doi":"https://doi.org/10.1109/isbi.2019.8759198","title":"Learning Disease Progression Models With Longitudinal Data and Missing Values","display_name":"Learning Disease Progression Models With Longitudinal Data and Missing Values","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2961895065","doi":"https://doi.org/10.1109/isbi.2019.8759198","mag":"2961895065"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2019.8759198","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759198","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015494003","display_name":"Rapha\u00ebl Couronn\u00e9","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raphael Couronne","raw_affiliation_strings":["ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010835736","display_name":"Marie Vidailhet","orcid":"https://orcid.org/0000-0002-2409-9143"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Vidailhet","raw_affiliation_strings":["ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004608080","display_name":"Jean\u2010Christophe Corvol","orcid":"https://orcid.org/0000-0001-7325-0199"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Christophe Corvol","raw_affiliation_strings":["ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029597969","display_name":"St\u00e9phane Leh\u00e9ricy","orcid":"https://orcid.org/0000-0002-5802-3518"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephane Lehericy","raw_affiliation_strings":["ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080254367","display_name":"Stanley Durrleman","orcid":"https://orcid.org/0000-0002-9450-6920"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stanley Durrleman","raw_affiliation_strings":["ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universite, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.893,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75146808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1033","last_page":"1037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9692999720573425,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9682000279426575,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.7787976861000061},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6248726844787598},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6224595308303833},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.5614383816719055},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5311492681503296},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5193087458610535},{"id":"https://openalex.org/keywords/data-modeling","display_name":"Data modeling","score":0.4564090669155121},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.44764232635498047},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.3724766969680786}],"concepts":[{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.7787976861000061},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6248726844787598},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6224595308303833},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.5614383816719055},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5311492681503296},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5193087458610535},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.4564090669155121},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.44764232635498047},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.3724766969680786},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2019.8759198","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2019.8759198","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W155981884","https://openalex.org/W171407896","https://openalex.org/W1851242489","https://openalex.org/W1992252533","https://openalex.org/W1993147091","https://openalex.org/W1993323478","https://openalex.org/W2024637850","https://openalex.org/W2055742299","https://openalex.org/W2065340506","https://openalex.org/W2082246284","https://openalex.org/W2963663218"],"related_works":["https://openalex.org/W4365211920","https://openalex.org/W3014948380","https://openalex.org/W4380551139","https://openalex.org/W4317695495","https://openalex.org/W4287117424","https://openalex.org/W4387506531","https://openalex.org/W4238433571","https://openalex.org/W2967848559","https://openalex.org/W4299831724","https://openalex.org/W4283803360"],"abstract_inverted_index":{"Statistical":[0],"methods":[1,169],"have":[2],"been":[3],"developed":[4],"for":[5,26,73,92,114],"the":[6,17,41,58,97,131,142,153,165],"analysis":[7],"of":[8,19,57,112,144,156,167],"longitunal":[9],"data":[10,44,115,195],"in":[11,30,39,45,100],"neurodegenerative":[12],"diseases.":[13],"To":[14],"cope":[15],"with":[16,116],"lack":[18],"temporal":[20],"markers":[21],"-":[22,34],"i.e.":[23],"to":[24,32,71,107,122,147,159,189],"account":[25,72],"subject-specific":[27],"disease":[28,61,192],"progression":[29,113,132,193],"regard":[31],"age":[33],"a":[35,109,124,137,186],"common":[36],"strategy":[37],"consists":[38],"realigning":[40],"individual":[42],"sequence":[43],"time.":[46],"Patient's":[47],"specific":[48],"trajectories":[49,133],"can":[50],"indeed":[51],"be":[52],"seen":[53],"as":[54,134],"spatiotemporal":[55],"perturbations":[56],"same":[59,98],"normative":[60],"trajectory.":[62],"However,":[63],"these":[64],"models":[65,104],"do":[66],"not":[67],"easily":[68],"allow":[69,108],"one":[70],"multimodal":[74,149],"data,":[75,150],"which":[76],"more":[77],"than":[78],"often":[79],"include":[80],"missing":[81,161,171],"values.":[82,162],"Indeed,":[83],"it":[84],"is":[85],"rare":[86],"that":[87,129],"imaging":[88],"and":[89,119,151,177,200],"clinical":[90,101,198],"examinations":[91],"instance":[93],"are":[94],"performed":[95],"at":[96],"frequency":[99,173],"protocols.":[102],"Multimodal":[103],"also":[105],"need":[106],"different":[110,117],"profile":[111],"structure":[118],"representation.We":[120],"propose":[121],"use":[123,141],"generative":[125,154],"mixed":[126],"effect":[127],"model":[128,158,184,190],"considers":[130],"curves":[135],"on":[136,174,185],"Riemannian":[138],"Manifold.":[139],"We":[140,163],"concept":[143],"product":[145],"manifold":[146],"handle":[148,160],"leverage":[152],"aspect":[155],"our":[157,168,183],"assess":[164],"robusteness":[166],"toward":[170],"values":[172],"both":[175],"synthetic":[176],"real":[178],"data.":[179],"Finally":[180],"we":[181],"apply":[182],"real-world":[187],"dataset":[188],"Parkinson's":[191],"from":[194,197],"derived":[196],"examination":[199],"imaging.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}