{"id":"https://openalex.org/W2806901774","doi":"https://doi.org/10.1109/isbi.2018.8363692","title":"A method for quantification of calponin expression in myoepithelial cells in immunohistochemical images of ductal carcinoma in situ","display_name":"A method for quantification of calponin expression in myoepithelial cells in immunohistochemical images of ductal carcinoma in situ","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2806901774","doi":"https://doi.org/10.1109/isbi.2018.8363692","mag":"2806901774","pmid":"https://pubmed.ncbi.nlm.nih.gov/30364524"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2018.8363692","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2018.8363692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6196724","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046257833","display_name":"Elliot Gray","orcid":"https://orcid.org/0000-0001-9894-3135"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elliot Gray","raw_affiliation_strings":["Department of Biomedical Engineering and Computational Biology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Computational Biology Program","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012631441","display_name":"Elizabeth Mitchell","orcid":null},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Mitchell","raw_affiliation_strings":["Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","Department of Cell, Oregon Health & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Cell, Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056577711","display_name":"Sonali Jindal","orcid":"https://orcid.org/0000-0002-3911-6815"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonali Jindal","raw_affiliation_strings":["Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","Department of Cell, Oregon Health & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Cell, Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062418760","display_name":"Pepper Schedin","orcid":"https://orcid.org/0000-0003-4244-987X"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pepper Schedin","raw_affiliation_strings":["Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","Department of Cell, Oregon Health & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Cancer Biology Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Cell, Oregon Health & Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003286550","display_name":"Young Hwan Chang","orcid":"https://orcid.org/0000-0001-8764-1959"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Hwan Chang","raw_affiliation_strings":["Department of Biomedical Engineering and Computational Biology Program","Oregon Health & Science University, Portland, OR, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Computational Biology Program","institution_ids":[]},{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, US","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4739,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76891739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":null,"first_page":"796","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myoepithelial-cell","display_name":"Myoepithelial cell","score":0.9565356969833374},{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"Ductal carcinoma","score":0.7412052154541016},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.7345598936080933},{"id":"https://openalex.org/keywords/calponin","display_name":"Calponin","score":0.6328393816947937},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6234769225120544},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5648679733276367},{"id":"https://openalex.org/keywords/ductal-cells","display_name":"Ductal cells","score":0.529660165309906},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4527374804019928},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.40724867582321167},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3494250178337097},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3470703959465027},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3292057514190674},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3011663556098938}],"concepts":[{"id":"https://openalex.org/C140884156","wikidata":"https://www.wikidata.org/wiki/Q1476681","display_name":"Myoepithelial cell","level":3,"score":0.9565356969833374},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.7412052154541016},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7345598936080933},{"id":"https://openalex.org/C2781122658","wikidata":"https://www.wikidata.org/wiki/Q24744812","display_name":"Calponin","level":3,"score":0.6328393816947937},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6234769225120544},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5648679733276367},{"id":"https://openalex.org/C2778148616","wikidata":"https://www.wikidata.org/wiki/Q5311600","display_name":"Ductal cells","level":3,"score":0.529660165309906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4527374804019928},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40724867582321167},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3494250178337097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3470703959465027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3292057514190674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3011663556098938}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi.2018.8363692","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2018.8363692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018)","raw_type":"proceedings-article"},{"id":"pmid:30364524","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30364524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:5142431","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6196724","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6196724","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6196724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6196724","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6196724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4277206828","display_name":null,"funder_award_id":"U54 CA209988","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7646530658","display_name":null,"funder_award_id":"R01 CA169175","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W104907341","https://openalex.org/W1855369421","https://openalex.org/W1874864581","https://openalex.org/W2024489351","https://openalex.org/W2049420719","https://openalex.org/W2049533803","https://openalex.org/W2056084888","https://openalex.org/W2057114171","https://openalex.org/W2092772483","https://openalex.org/W2118246710","https://openalex.org/W2124264234","https://openalex.org/W2133059825","https://openalex.org/W2151676484","https://openalex.org/W2410957302","https://openalex.org/W2593134963","https://openalex.org/W2604591951","https://openalex.org/W2610096391","https://openalex.org/W2746765501","https://openalex.org/W2748339352","https://openalex.org/W6714982484"],"related_works":["https://openalex.org/W2910715035","https://openalex.org/W2379236807","https://openalex.org/W2063711240","https://openalex.org/W2030368851","https://openalex.org/W2003038890","https://openalex.org/W1963916446","https://openalex.org/W1519627309","https://openalex.org/W2007236240","https://openalex.org/W2527749526","https://openalex.org/W2124264234"],"abstract_inverted_index":{"Ductal":[0],"carcinoma":[1],"in":[2,38,83],"situ":[3],"(DCIS)":[4],"is":[5,49,86],"breast":[6,33],"cancer":[7,34],"confined":[8],"within":[9],"mammary":[10],"ducts,":[11],"surrounded":[12],"by":[13,129],"an":[14],"intact":[15],"myoepithelial":[16,80,113],"cell":[17,81],"layer":[18],"that":[19,61],"prevents":[20],"local":[21],"invasion.":[22],"A":[23],"DCIS":[24,48,68,92],"diagnosis":[25],"confers":[26],"increased":[27],"lifetime":[28],"risk":[29,66,100],"of":[30,67,79,112,121],"developing":[31],"invasive":[32],"(IBC)":[35],"and":[36,43,94,98,139],"results":[37],"surgical":[39],"excision":[40],"with":[41,55,133],"radiation,":[42],"possibly":[44],"endocrine-":[45],"or":[46],"chemo-therapy.":[47],"known":[50],"to":[51,88,109,144],"be":[52],"over":[53],"treated,":[54],"associated":[56],"co-morbidities.":[57],"Biomarkers":[58],"are":[59],"needed":[60],"delineate":[62,95],"patients":[63,71],"at":[64],"low":[65,97],"progression":[69,93],"from":[70],"requiring":[72],"more":[73],"aggressive":[74],"treatment.":[75],"Investigating":[76],"the":[77],"role":[78],"differentiation":[82,114],"barrier":[84],"function":[85],"anticipated":[87],"provide":[89],"insight":[90],"into":[91],"between":[96],"high":[99,106,131],"lesions.":[101],"Here,":[102],"we":[103],"develop":[104],"a":[105,122,130,145],"throughput":[107],"technique":[108],"assess":[110],"loss":[111],"markers.":[115],"This":[116],"method":[117],"facilitates":[118],"automated":[119],"analysis":[120],"clinically":[123],"relevant":[124],"histopathologic":[125],"feature,":[126],"as":[127],"demonstrated":[128],"correlation":[132],"pathologist":[134],"annotation":[135],"(r":[136],"=":[137],"0.959),":[138],"further,":[140],"contributes":[141],"analytical":[142],"foundations":[143],"multiplexed":[146],"immunohistochemistry":[147],"(IHC)":[148],"approach.":[149]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}