{"id":"https://openalex.org/W2657857444","doi":"https://doi.org/10.1109/isbi.2017.7950575","title":"Brain geometry persistent homology marker for Parkinson's disease","display_name":"Brain geometry persistent homology marker for Parkinson's disease","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2657857444","doi":"https://doi.org/10.1109/isbi.2017.7950575","mag":"2657857444"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2017.7950575","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950575","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052413577","display_name":"Amanmeet Garg","orcid":null},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amanmeet Garg","raw_affiliation_strings":["School of Engineering Science, Simon Fraser University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering Science, Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014222179","display_name":"Donghuan Lu","orcid":"https://orcid.org/0000-0002-8399-7410"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Donghuan Lu","raw_affiliation_strings":["School of Engineering Science, Simon Fraser University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering Science, Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026662287","display_name":"Karteek Popuri","orcid":"https://orcid.org/0000-0002-1729-3255"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karteek Popuri","raw_affiliation_strings":["School of Engineering Science, Simon Fraser University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering Science, Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000972836","display_name":"Mirza Faisal Beg","orcid":"https://orcid.org/0000-0001-6706-8630"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mirza Faisal Beg","raw_affiliation_strings":["School of Engineering Science, Simon Fraser University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering Science, Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2393,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55957172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"46","issue":null,"first_page":"525","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9585999846458435,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persistent-homology","display_name":"Persistent homology","score":0.8986060619354248},{"id":"https://openalex.org/keywords/topological-data-analysis","display_name":"Topological data analysis","score":0.7649576663970947},{"id":"https://openalex.org/keywords/point-cloud","display_name":"Point cloud","score":0.6839600205421448},{"id":"https://openalex.org/keywords/persistence","display_name":"Persistence (discontinuity)","score":0.5839591026306152},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.4991035461425781},{"id":"https://openalex.org/keywords/timeline","display_name":"Timeline","score":0.4663272202014923},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4628986418247223},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.45679640769958496},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.4232825040817261},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39579126238822937},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.39060160517692566},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3106972277164459},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28745129704475403},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26035767793655396},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2389955222606659},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.17982786893844604},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.1782999336719513},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1609087884426117},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.12059584259986877},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09476175904273987}],"concepts":[{"id":"https://openalex.org/C2874115","wikidata":"https://www.wikidata.org/wiki/Q17099562","display_name":"Persistent homology","level":2,"score":0.8986060619354248},{"id":"https://openalex.org/C2776477805","wikidata":"https://www.wikidata.org/wiki/Q4460773","display_name":"Topological data analysis","level":2,"score":0.7649576663970947},{"id":"https://openalex.org/C131979681","wikidata":"https://www.wikidata.org/wiki/Q1899648","display_name":"Point cloud","level":2,"score":0.6839600205421448},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.5839591026306152},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4991035461425781},{"id":"https://openalex.org/C4438859","wikidata":"https://www.wikidata.org/wiki/Q186117","display_name":"Timeline","level":2,"score":0.4663272202014923},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4628986418247223},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.45679640769958496},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4232825040817261},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39579126238822937},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.39060160517692566},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3106972277164459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28745129704475403},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26035767793655396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2389955222606659},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17982786893844604},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.1782999336719513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1609087884426117},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.12059584259986877},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09476175904273987},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2017.7950575","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950575","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.41999998688697815}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W159761463","https://openalex.org/W2002165972","https://openalex.org/W2113319997","https://openalex.org/W2132291063","https://openalex.org/W2149185044","https://openalex.org/W2167822639","https://openalex.org/W3015234645","https://openalex.org/W6681677808"],"related_works":["https://openalex.org/W2886923060","https://openalex.org/W2887690685","https://openalex.org/W2129730857","https://openalex.org/W4287394697","https://openalex.org/W3119689987","https://openalex.org/W3120766012","https://openalex.org/W4287826795","https://openalex.org/W3210518039","https://openalex.org/W2567662842","https://openalex.org/W4206186921"],"abstract_inverted_index":{"The":[0,12,106],"geometry":[1,14,51],"of":[2,63,73,82,118],"the":[3,40,49,59,70,83,95,103,116,119,126],"human":[4],"brain":[5,13,50,131],"changes":[6],"due":[7],"to":[8,17,123],"age":[9],"and":[10,57,97,128],"neurodegeneration.":[11],"is":[15],"expected":[16],"undergo":[18],"a":[19,25,53,74,78,111],"similar":[20],"change":[21,30],"in":[22,33,44,77,110],"shape":[23],"with":[24],"normal":[26],"aging,":[27],"however":[28],"such":[29],"may":[31],"differ":[32],"patients":[34],"suffering":[35],"from":[36,94],"neurodegenerative":[37],"disorders.":[38],"In":[39],"novel":[41],"framework":[42],"proposed":[43],"this":[45,64],"work,":[46],"we":[47,68],"model":[48],"as":[52],"3D":[54],"point":[55,65],"cloud":[56],"study":[58],"algebraic":[60],"topology":[61,85],"features":[62,91,122],"cloud.":[66],"Specifically,":[67],"compute":[69],"persistence":[71,88,120],"timelines":[72,96],"simplicial":[75,80],"complex":[76],"multiscale":[79],"homology":[81],"underlying":[84],"space.":[86],"Further,":[87],"landscape":[89,121],"summary":[90],"are":[92],"obtained":[93,109],"studied":[98],"for":[99],"their":[100],"difference":[101],"between":[102,125],"two":[104],"groups.":[105],"statistical":[107],"significance":[108],"permutation":[112],"testing":[113],"experiments":[114],"highlights":[115],"ability":[117],"differentiate":[124],"PD":[127],"healthy":[129],"control":[130],"geometry.":[132]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}