{"id":"https://openalex.org/W2677910651","doi":"https://doi.org/10.1109/isbi.2017.7950535","title":"Heritability of connectivity and disconnectivity of the brain in a population-based study","display_name":"Heritability of connectivity and disconnectivity of the brain in a population-based study","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2677910651","doi":"https://doi.org/10.1109/isbi.2017.7950535","mag":"2677910651"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2017.7950535","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066428819","display_name":"C. D. de LANGEN","orcid":"https://orcid.org/0000-0002-1261-9797"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Carolyn D. Langen","raw_affiliation_strings":["Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029373833","display_name":"Gennady V. Roshchupkin","orcid":"https://orcid.org/0000-0002-3403-2313"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gennady Roshchupkin","raw_affiliation_strings":["Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000910889","display_name":"Hieab H.H. Adams","orcid":"https://orcid.org/0000-0003-3687-2508"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hieab H. Adams","raw_affiliation_strings":["Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042005913","display_name":"Marius de Groot","orcid":"https://orcid.org/0000-0003-0154-1397"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marius de Groot","raw_affiliation_strings":["Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029613832","display_name":"Frans M. Vos","orcid":"https://orcid.org/0000-0002-8688-9546"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frans Vos","raw_affiliation_strings":["Technische Universiteit Delft, Delft, Zuid-Holland, NL"],"affiliations":[{"raw_affiliation_string":"Technische Universiteit Delft, Delft, Zuid-Holland, NL","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013665840","display_name":"Meike W. Vernooij","orcid":"https://orcid.org/0000-0003-4658-2176"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Meike W. Vernooij","raw_affiliation_strings":["Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036303967","display_name":"M. Arfan Ikram","orcid":"https://orcid.org/0000-0003-0372-8585"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Arfan Ikram","raw_affiliation_strings":["Department of Neurology, Erasmus MC, Rotterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038384386","display_name":"Wiro J. Niessen","orcid":"https://orcid.org/0000-0002-5822-1995"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wiro J. Niessen","raw_affiliation_strings":["Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands","Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5066428819"],"corresponding_institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07208716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":"349","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.8778179287910461},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.710924506187439},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.6223748326301575},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5780856013298035},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5642956495285034},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.45462703704833984},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.426904559135437},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.40265771746635437},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38386526703834534},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.37644582986831665},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.35079920291900635},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.33793818950653076},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.181298166513443},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.06991127133369446}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.8778179287910461},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.710924506187439},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.6223748326301575},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5780856013298035},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5642956495285034},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.45462703704833984},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.426904559135437},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.40265771746635437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38386526703834534},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37644582986831665},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.35079920291900635},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33793818950653076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.181298166513443},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.06991127133369446},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2017.7950535","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/8c0e65bd-8066-440c-8367-bff32775aeb0","is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/8c0e65bd-8066-440c-8367-bff32775aeb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/book"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1904475182","https://openalex.org/W1995064441","https://openalex.org/W2018017287","https://openalex.org/W2022891394","https://openalex.org/W2054183703","https://openalex.org/W2069504513","https://openalex.org/W2122477279","https://openalex.org/W2124953625","https://openalex.org/W2126824241","https://openalex.org/W2128261720","https://openalex.org/W2140054173","https://openalex.org/W2148163686","https://openalex.org/W2155496693","https://openalex.org/W2155756772","https://openalex.org/W2166557549","https://openalex.org/W2167822639","https://openalex.org/W2189810169","https://openalex.org/W2339221152","https://openalex.org/W2528236220","https://openalex.org/W4211004056","https://openalex.org/W7025299928"],"related_works":["https://openalex.org/W1520477417","https://openalex.org/W3150454329","https://openalex.org/W4250679599","https://openalex.org/W4236064658","https://openalex.org/W3136590534","https://openalex.org/W3082461017","https://openalex.org/W4280586040","https://openalex.org/W4232465970","https://openalex.org/W3210626554","https://openalex.org/W4281670718"],"abstract_inverted_index":{"We":[0],"present":[1],"the":[2,8,17,22,29,45,61,101,105,116,120],"largest":[3],"population-based":[4],"heritability":[5,76],"study":[6],"of":[7,24,40,80,119],"human":[9,121],"brain":[10],"structural":[11],"connectome,":[12,102],"including":[13],"a":[14],"pathology-sensitive":[15],"extension,":[16],"disconnectome.":[18,64],"The":[19,31,92],"disconnectome":[20,34,93],"maps":[21],"effect":[23],"white":[25],"matter":[26],"lesions":[27],"throughout":[28],"brain.":[30,122],"connectome":[32,62],"and":[33,51,63],"were":[35,57,66,86],"generated":[36],"from":[37,44,82],"diffusion-weighted":[38],"images":[39],"3255":[41],"unrelated":[42],"subjects":[43],"Rotterdam":[46],"Study":[47],"aged":[48],"between":[49,73],"45":[50],"99":[52],"years.":[53],"Graph":[54],"theory":[55],"measures":[56,79,99],"derived":[58],"for":[59,75],"both":[60],"Genotypes":[65],"used":[67],"to":[68,84],"derive":[69],"genetic":[70,117],"relationship":[71],"matrices":[72],"individuals":[74],"analyses.":[77],"High":[78],"heritability,":[81],"33%":[83],"51%,":[85],"found":[87],"across":[88],"all":[89],"connectivity":[90,98],"measures.":[91],"showed":[94],"more":[95],"significantly":[96],"heritable":[97],"than":[100],"suggesting":[103],"that":[104],"new":[106],"proposed":[107],"measure":[108],"may":[109],"reveal":[110],"additional":[111],"or":[112],"complementary":[113],"information":[114],"about":[115],"architecture":[118]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}