{"id":"https://openalex.org/W2649308454","doi":"https://doi.org/10.1109/isbi.2017.7950531","title":"Automated dense neuronal fiber tracing and connectivity mapping at cellular level","display_name":"Automated dense neuronal fiber tracing and connectivity mapping at cellular level","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2649308454","doi":"https://doi.org/10.1109/isbi.2017.7950531","mag":"2649308454"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2017.7950531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026644166","display_name":"Laura J. Brattain","orcid":null},"institutions":[{"id":"https://openalex.org/I4210122954","display_name":"MIT Lincoln Laboratory","ror":"https://ror.org/022z6jk58","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210122954","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura J. Brattain","raw_affiliation_strings":["MIT Lincoln Laboratory, Lexington, MA"],"affiliations":[{"raw_affiliation_string":"MIT Lincoln Laboratory, Lexington, MA","institution_ids":["https://openalex.org/I4210122954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054039049","display_name":"Brian A. Telfer","orcid":"https://orcid.org/0000-0002-3534-7149"},"institutions":[{"id":"https://openalex.org/I4210122954","display_name":"MIT Lincoln Laboratory","ror":"https://ror.org/022z6jk58","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210122954","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Telfer","raw_affiliation_strings":["MIT Lincoln Laboratory, Lexington, MA"],"affiliations":[{"raw_affiliation_string":"MIT Lincoln Laboratory, Lexington, MA","institution_ids":["https://openalex.org/I4210122954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103227438","display_name":"Siddharth Samsi","orcid":"https://orcid.org/0009-0000-2884-9688"},"institutions":[{"id":"https://openalex.org/I4210122954","display_name":"MIT Lincoln Laboratory","ror":"https://ror.org/022z6jk58","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210122954","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth Samsi","raw_affiliation_strings":["MIT Lincoln Laboratory, Lexington, MA"],"affiliations":[{"raw_affiliation_string":"MIT Lincoln Laboratory, Lexington, MA","institution_ids":["https://openalex.org/I4210122954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004427808","display_name":"Taeyun Ku","orcid":"https://orcid.org/0000-0001-9447-7579"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taeyun Ku","raw_affiliation_strings":["Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621297","display_name":"Heejin Choi","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heejin Choi","raw_affiliation_strings":["Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060000983","display_name":"Kwanghun Chung","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwanghun Chung","raw_affiliation_strings":["Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026644166"],"corresponding_institution_ids":["https://openalex.org/I4210122954"],"apc_list":null,"apc_paid":null,"fwci":0.1282,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45854985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"332","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7912212610244751},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.7002854347229004},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.568768322467804},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5433514714241028},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.4891110062599182},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.4690207540988922},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44627365469932556},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.4288520812988281},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4256870746612549}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7912212610244751},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.7002854347229004},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.568768322467804},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5433514714241028},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4891110062599182},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4690207540988922},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44627365469932556},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.4288520812988281},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4256870746612549},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2017.7950531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2017.7950531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.4399999976158142}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1559344731","https://openalex.org/W1563397979","https://openalex.org/W1898703532","https://openalex.org/W1969525503","https://openalex.org/W1986141983","https://openalex.org/W1989396876","https://openalex.org/W1999653836","https://openalex.org/W1999976658","https://openalex.org/W2000023163","https://openalex.org/W2005926822","https://openalex.org/W2008781224","https://openalex.org/W2014281241","https://openalex.org/W2018227909","https://openalex.org/W2026354831","https://openalex.org/W2030179996","https://openalex.org/W2036901575","https://openalex.org/W2048733914","https://openalex.org/W2051036306","https://openalex.org/W2076507262","https://openalex.org/W2085845714","https://openalex.org/W2086498469","https://openalex.org/W2089315051","https://openalex.org/W2114240017","https://openalex.org/W2121289914","https://openalex.org/W2124953625","https://openalex.org/W2129534965","https://openalex.org/W2136395604","https://openalex.org/W2138905229","https://openalex.org/W2161515775","https://openalex.org/W2337129827","https://openalex.org/W2404192493","https://openalex.org/W2494923364","https://openalex.org/W6679367408"],"related_works":["https://openalex.org/W2888673113","https://openalex.org/W4295532600","https://openalex.org/W2056065966","https://openalex.org/W2063823869","https://openalex.org/W2352602608","https://openalex.org/W2062641654","https://openalex.org/W2212288070","https://openalex.org/W4388446985","https://openalex.org/W2381399653","https://openalex.org/W1997160662"],"abstract_inverted_index":{"With":[0],"the":[1,50,74,119,139,149],"advancement":[2],"of":[3,49,64,109],"high":[4,7],"throughput":[5],"and":[6,22,100,128,130],"resolution":[8,43],"volumetric":[9],"brain":[10,125,146],"imaging,":[11],"there":[12],"is":[13,30,59,83],"an":[14,89],"unmet":[15],"need":[16],"to":[17,61,72,88,121,141],"trace":[18],"dense":[19],"neuron":[20,25],"fibers":[21,63],"study":[23],"long-range":[24,133],"connectivity.":[26],"An":[27],"initial":[28,90],"pipeline":[29],"described":[31],"for":[32,98,103,116],"processing":[33],"cellular-level":[34],"neuronal":[35],"fiber":[36,75,105],"data":[37,91],"acquired":[38],"by":[39],"a":[40,54,79],"new":[41],"super":[42],"imaging":[44],"method":[45],"called":[46],"Magnified":[47],"Analysis":[48],"Proteome":[51],"(MAP).":[52],"First,":[53],"multiscale":[55],"vessel":[56],"enhancement":[57],"filter":[58],"applied":[60],"segment":[62],"different":[65],"diameters.":[66],"Morphological":[67],"operations":[68],"are":[69],"then":[70],"employed":[71],"extract":[73],"centerlines,":[76],"from":[77],"which":[78],"3D":[80],"connectivity":[81,134],"map":[82],"computed.":[84],"Applying":[85],"this":[86],"approach":[87],"set":[92],"yielded":[93],"2%":[94],"equal":[95],"error":[96],"rate":[97],"segmentation":[99],"92%":[101],"accuracy":[102],"end-to-end":[104],"tracing":[106],"(22":[107],"out":[108],"24":[110],"hand-traced":[111],"fibers).":[112],"Future":[113],"work":[114,137],"calls":[115],"scaling":[117],"up":[118],"algorithm":[120],"process":[122],"much":[123],"larger":[124],"datasets":[126],"(terabytes":[127],"above)":[129],"performing":[131],"graph-based":[132],"analysis.":[135],"This":[136],"has":[138],"potential":[140],"extend":[142],"our":[143],"knowledge":[144],"on":[145],"networks":[147],"at":[148],"cellular":[150],"level.":[151]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}