{"id":"https://openalex.org/W2424770239","doi":"https://doi.org/10.1109/isbi.2016.7493504","title":"Functional connectivity analysis for thalassemia disease based on a graphical lasso model","display_name":"Functional connectivity analysis for thalassemia disease based on a graphical lasso model","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2424770239","doi":"https://doi.org/10.1109/isbi.2016.7493504","mag":"2424770239","pmid":"https://pubmed.ncbi.nlm.nih.gov/30344891"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493504","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493504","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.univ-grenoble-alpes.fr/hal-01355161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003223460","display_name":"Julie Coloigner","orcid":"https://orcid.org/0000-0001-7774-8015"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julie Coloigner","raw_affiliation_strings":["CIBORG, Department of Radiology, Childrens Hospital Los Angeles, USA","COMPUTATIONAL IMAGING OF BRAIN ORGANIZATION RESEARCH GROUP"],"affiliations":[{"raw_affiliation_string":"CIBORG, Department of Radiology, Childrens Hospital Los Angeles, USA","institution_ids":[]},{"raw_affiliation_string":"COMPUTATIONAL IMAGING OF BRAIN ORGANIZATION RESEARCH GROUP","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010296747","display_name":"Ronald Phlypo","orcid":"https://orcid.org/0000-0003-4310-7994"},"institutions":[{"id":"https://openalex.org/I4210121626","display_name":"Signal Processing (United States)","ror":"https://ror.org/021gzyw51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121626"]},{"id":"https://openalex.org/I4210124956","display_name":"Grenoble Images Parole Signal Automatique","ror":"https://ror.org/02wrme198","country_code":"FR","type":"facility","lineage":["https://openalex.org/I106785703","https://openalex.org/I1294671590","https://openalex.org/I4210124956","https://openalex.org/I899635006","https://openalex.org/I899635006"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Ronald Phlypo","raw_affiliation_strings":["Research group ViBS (vision and brain signal processing), GIPSA-lab, Grenoble, France","GIPSA - Vision and Brain Signal Processing"],"affiliations":[{"raw_affiliation_string":"Research group ViBS (vision and brain signal processing), GIPSA-lab, Grenoble, France","institution_ids":[]},{"raw_affiliation_string":"GIPSA - Vision and Brain Signal Processing","institution_ids":["https://openalex.org/I4210124956","https://openalex.org/I4210121626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079735182","display_name":"Adam Bush","orcid":"https://orcid.org/0000-0002-7787-596X"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Bush","raw_affiliation_strings":["Department of Cardiology, Childrens Hospital Los Angeles, USA","Department of Cardiology"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Childrens Hospital Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Department of Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053267424","display_name":"Natasha Lepor\u00e9","orcid":"https://orcid.org/0000-0002-8379-674X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natasha Lepore","raw_affiliation_strings":["CIBORG, Department of Radiology, Childrens Hospital Los Angeles, USA","COMPUTATIONAL IMAGING OF BRAIN ORGANIZATION RESEARCH GROUP"],"affiliations":[{"raw_affiliation_string":"CIBORG, Department of Radiology, Childrens Hospital Los Angeles, USA","institution_ids":[]},{"raw_affiliation_string":"COMPUTATIONAL IMAGING OF BRAIN ORGANIZATION RESEARCH GROUP","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034495408","display_name":"John C. Wood","orcid":"https://orcid.org/0000-0003-0996-3439"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Wood","raw_affiliation_strings":["Department of Cardiology, Childrens Hospital Los Angeles, USA","Department of Cardiology"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Childrens Hospital Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Department of Cardiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003223460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3938,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65520392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2016","issue":null,"first_page":"1295","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9821000099182129,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperparameter","display_name":"Hyperparameter","score":0.6989045143127441},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5687795877456665},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5658299326896667},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.527203381061554},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.5026538372039795},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.4799644947052002},{"id":"https://openalex.org/keywords/thalassemia","display_name":"Thalassemia","score":0.4425830841064453},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3988493084907532},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39777758717536926},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22162944078445435},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.17844387888908386},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11011680960655212},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08375373482704163}],"concepts":[{"id":"https://openalex.org/C8642999","wikidata":"https://www.wikidata.org/wiki/Q4171168","display_name":"Hyperparameter","level":2,"score":0.6989045143127441},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5687795877456665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5658299326896667},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.527203381061554},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5026538372039795},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.4799644947052002},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.4425830841064453},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3988493084907532},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39777758717536926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22162944078445435},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17844387888908386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11011680960655212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08375373482704163},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/isbi.2016.7493504","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493504","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:30344891","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30344891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:HAL:hal-01355161v1","is_oa":true,"landing_page_url":"https://hal.univ-grenoble-alpes.fr/hal-01355161","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedicalimaging.org/2016/","raw_type":"Conference papers"},{"id":"pmh:oai:europepmc.org:5137412","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6192020","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6192020","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6192020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-01355161v1","is_oa":true,"landing_page_url":"https://hal.univ-grenoble-alpes.fr/hal-01355161","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedicalimaging.org/2016/","raw_type":"Conference papers"},"sustainable_development_goals":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W70615654","https://openalex.org/W91247477","https://openalex.org/W1589079399","https://openalex.org/W1690941339","https://openalex.org/W1906883763","https://openalex.org/W1973612122","https://openalex.org/W2059671828","https://openalex.org/W2060899536","https://openalex.org/W2116266236","https://openalex.org/W2130010412","https://openalex.org/W2132555912","https://openalex.org/W2143661428","https://openalex.org/W3102360731","https://openalex.org/W6785615522"],"related_works":["https://openalex.org/W2140186469","https://openalex.org/W4390421286","https://openalex.org/W4280563792","https://openalex.org/W4389724018","https://openalex.org/W4318719684","https://openalex.org/W3183136280","https://openalex.org/W4318559728","https://openalex.org/W2775233965","https://openalex.org/W4360995913","https://openalex.org/W4312193868"],"abstract_inverted_index":{"Thalassemia":[0],"is":[1,40,96,123,131],"a":[2,26,72,84,99],"congenital":[3],"disorder":[4],"of":[5,51,75,145],"hemoglobin":[6],"synthesis":[7],"which":[8],"can":[9],"lead":[10],"to":[11,24,30,115,139],"thromboembolic":[12],"events":[13],"and":[14,34,47,68],"stroke":[15],"in":[16,56],"the":[17,52,76,80,90,108,112,116,125,135,141,146,151,159,164],"brain.":[18],"In":[19],"this":[20,61],"work":[21],"we":[22,82,106],"propose":[23,83],"use":[25],"functional":[27,43],"connectivity":[28,38,62,110,161],"model":[29,104,126],"discriminate":[31],"between":[32],"control":[33,113,129],"diseased":[35],"subjects.":[36],"Our":[37,120],"measure":[39],"based":[41,88],"on":[42,89,128],"magnetic":[44],"resonance":[45],"imaging,":[46],"hence":[48],"common":[49],"variations":[50],"blood":[53],"oxygenation":[54],"level":[55],"spatially":[57],"distant":[58],"areas.":[59],"Analyzing":[60],"could":[63],"highlight":[64],"abnormal":[65],"neuronal":[66],"activation":[67],"provide":[69],"us":[70],"with":[71,154],"descriptor":[73],"(bio-marker)":[74],"disease.":[77],"To":[78,102],"estimate":[79],"connectivity,":[81],"robust":[85],"learning":[86],"scheme":[87],"graphical":[91],"lasso":[92],"model,":[93],"whose":[94],"hyperparameter":[95],"validated":[97],"within":[98],"cross-validation":[100],"scheme.":[101],"analyze":[103],"fit,":[105],"transfer":[107],"mean":[109],"from":[111],"group":[114],"thalassemic":[117],"patient":[118],"group.":[119],"null":[121],"hypothesis":[122],"that":[124,150],"learned":[127],"subjects":[130],"perfectly":[132],"adequate":[133],"(in":[134],"maximum":[136],"likelihood":[137],"sense)":[138],"describe":[140],"patients.":[142],"The":[143],"results":[144],"permutation":[147],"test":[148],"suggest":[149],"some":[152],"patients":[153],"thalassemia":[155],"do":[156],"not":[157],"have":[158],"same":[160],"structure":[162],"as":[163],"control.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}