{"id":"https://openalex.org/W2438943665","doi":"https://doi.org/10.1109/isbi.2016.7493458","title":"An experimental investigation of labeling efficiency for pseudo-continuous arterial spin labeling","display_name":"An experimental investigation of labeling efficiency for pseudo-continuous arterial spin labeling","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2438943665","doi":"https://doi.org/10.1109/isbi.2016.7493458","mag":"2438943665"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493458","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019325729","display_name":"Yaqiong Chai","orcid":"https://orcid.org/0000-0003-4175-6720"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yaqiong Chai","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, CA, USA","Department of Radiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Radiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079735182","display_name":"Adam Bush","orcid":"https://orcid.org/0000-0002-7787-596X"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Bush","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, CA, USA","Division of Cardiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Cardiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003223460","display_name":"Julie Coloigner","orcid":"https://orcid.org/0000-0001-7774-8015"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Coloigner","raw_affiliation_strings":["Department of Radiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026107160","display_name":"Xiaoping Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Qu","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, CA, USA","Department of Radiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Radiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108622445","display_name":"Jonathan Chia","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131230","display_name":"Philips (United States)","ror":"https://ror.org/03kw6wr76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122849","https://openalex.org/I4210131230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Chia","raw_affiliation_strings":["Division of Clinical Science, Philips Healthcare, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Division of Clinical Science, Philips Healthcare, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210131230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053267424","display_name":"Natasha Lepor\u00e9","orcid":"https://orcid.org/0000-0002-8379-674X"},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Lepore","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, CA, USA","Department of Radiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Radiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034495408","display_name":"John C. Wood","orcid":"https://orcid.org/0000-0003-0996-3439"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Wood","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, CA, USA","Division of Cardiology, Children's Hospital Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Cardiology, Children's Hospital Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5019325729"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"],"apc_list":null,"apc_paid":null,"fwci":0.2847,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6423713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"73","issue":null,"first_page":"1101","last_page":"1104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-spin-labeling","display_name":"Arterial spin labeling","score":0.8847076892852783},{"id":"https://openalex.org/keywords/spins","display_name":"Spins","score":0.6529795527458191},{"id":"https://openalex.org/keywords/laminar-flow","display_name":"Laminar flow","score":0.6499714255332947},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.5650523900985718},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.5295392274856567},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.5286529660224915},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.4306626617908478},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.35731083154678345},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3451346158981323},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34120532870292664},{"id":"https://openalex.org/keywords/condensed-matter-physics","display_name":"Condensed matter physics","score":0.21639099717140198},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.21317347884178162},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.16285783052444458},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1528327465057373}],"concepts":[{"id":"https://openalex.org/C3018723549","wikidata":"https://www.wikidata.org/wiki/Q56284158","display_name":"Arterial spin labeling","level":3,"score":0.8847076892852783},{"id":"https://openalex.org/C2778870898","wikidata":"https://www.wikidata.org/wiki/Q7577658","display_name":"Spins","level":2,"score":0.6529795527458191},{"id":"https://openalex.org/C76563973","wikidata":"https://www.wikidata.org/wiki/Q189452","display_name":"Laminar flow","level":2,"score":0.6499714255332947},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5650523900985718},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5295392274856567},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5286529660224915},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.4306626617908478},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35731083154678345},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3451346158981323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34120532870292664},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.21639099717140198},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.21317347884178162},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.16285783052444458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1528327465057373},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2016.7493458","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:hal-01710699v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01710699","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI 2016), Apr 2016, Prague, France. &#x27E8;10.1109/ISBI.2016.7493458&#x27E9;","raw_type":"Conference papers"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1977896272","https://openalex.org/W2006096283","https://openalex.org/W2012602334","https://openalex.org/W2040032797","https://openalex.org/W2048310364","https://openalex.org/W2052644075","https://openalex.org/W2074155898","https://openalex.org/W2107093413","https://openalex.org/W2109381172","https://openalex.org/W2116641010","https://openalex.org/W2116991535","https://openalex.org/W2125587122","https://openalex.org/W2133506632","https://openalex.org/W4235770099","https://openalex.org/W6677298770"],"related_works":["https://openalex.org/W2070060620","https://openalex.org/W2691788872","https://openalex.org/W2040386745","https://openalex.org/W2593787220","https://openalex.org/W2114144996","https://openalex.org/W2557712647","https://openalex.org/W1939164019","https://openalex.org/W1985261403","https://openalex.org/W4401573531","https://openalex.org/W2355116690"],"abstract_inverted_index":{"Cerebral":[0],"blood":[1,32,79,212],"flow":[2,37,213],"(CBF)":[3],"is":[4,40,53,75,195,215],"an":[5,119,142,196],"important":[6,197],"physiological":[7,69],"metric":[8],"of":[9,30,51,59,122,164],"neurovascular":[10],"health":[11],"that":[12],"can":[13],"be":[14],"measured":[15],"non-invasively":[16],"using":[17,99,127,138],"Arterial":[18],"Spin":[19],"Labeling":[20,23],"(ASL)":[21],"MRI.":[22],"efficiency":[24,50],"(LE)":[25],"refers":[26],"to":[27,186],"the":[28,31,36,63,84,89,128,132,171,181],"percentage":[29],"spins":[33,60],"recruited":[34],"for":[35,44,94],"estimation":[38,96],"and":[39,87,107,134,208],"a":[41,48],"crucial":[42],"parameter":[43],"ASL":[45,106,146,200],"quantification.":[46],"Traditionally,":[47],"labeling":[49,64,144],"0.85":[52],"assumed":[54,120,143],"based":[55],"on":[56,78],"Bloch":[57,92],"simulations":[58,93],"moving":[61],"across":[62,83,88],"plane":[65],"at":[66],"laminar,":[67],"constant":[68],"velocities.":[70],"In":[71],"practice,":[72],"however,":[73],"LE":[74,95,121,125,136],"highly":[76,216],"dependent":[77],"velocities,":[80],"which":[81],"vary":[82],"cardiac":[85],"cycle":[86],"vessel.":[90],"Here,":[91],"were":[97,113],"performed":[98],"time-varying":[100],"velocities":[101],"(TVV).":[102],"The":[103,162],"agreement":[104],"between":[105],"phase":[108],"contrast":[109],"(PC)":[110],"CBF":[111],"estimates":[112],"compared":[114],"under":[115],"three":[116],"conditions:":[117],"a)":[118],"0.85,":[123],"b)":[124],"calculated":[126,137],"average":[129,172],"velocity":[130,159,173,214],"in":[131,199,203],"vessel,":[133],"c)":[135],"TVV":[139,165],"profiles.":[140],"Using":[141],"efficiency,":[145],"underestimated":[147],"PC":[148,187],"by":[149,157],"15.6\u00b14.4":[150],"ml/100g/min,":[151,176,191],"p<0.003.":[152],"This":[153],"bias":[154,183],"was":[155],"eliminated":[156],"both":[158],"correction":[160,174,194],"techniques.":[161],"use":[163],"yielded":[166],"systemically":[167],"higher":[168],"flows":[169],"than":[170],"(\u22123.6\u00b13.1":[175],"p<0.276)":[177],"as":[178,180,206],"well":[179],"lowest":[182],"with":[184],"respect":[185],"(\u22120.9":[188],"\u00b1":[189],"3.01":[190],"p=0.777).":[192],"Velocity":[193],"procedure":[198],"quantification,":[201],"particularly":[202],"populations":[204],"such":[205],"children":[207],"anemic":[209],"subjects":[210],"where":[211],"variable.":[217]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}