{"id":"https://openalex.org/W2420280888","doi":"https://doi.org/10.1109/isbi.2016.7493440","title":"Phenotypic characterization of breast invasive carcinoma via transferable tissue morphometric patterns learned from glioblastoma multiforme","display_name":"Phenotypic characterization of breast invasive carcinoma via transferable tissue morphometric patterns learned from glioblastoma multiforme","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2420280888","doi":"https://doi.org/10.1109/isbi.2016.7493440","mag":"2420280888","pmid":"https://pubmed.ncbi.nlm.nih.gov/27390615"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493440","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493440","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108090164","display_name":"Ju Han","orcid":null},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ju Han","raw_affiliation_strings":["Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029124461","display_name":"Gerald Fontenay","orcid":null},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald V Fontenay","raw_affiliation_strings":["Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008739295","display_name":"Yunfu Wang","orcid":"https://orcid.org/0000-0002-5794-9634"},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yunfu Wang","raw_affiliation_strings":["Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA; Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China","Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","Department of Neurology, Hubei University of Medicine, Shiyan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA; Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China","institution_ids":["https://openalex.org/I1285929390"]},{"raw_affiliation_string":"Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Department of Neurology, Hubei University of Medicine, Shiyan, Hubei, China","institution_ids":["https://openalex.org/I1285929390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032768695","display_name":"Jian\u2010Hua Mao","orcid":"https://orcid.org/0000-0001-9320-6021"},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Hua Mao","raw_affiliation_strings":["Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047619963","display_name":"Hang Chang","orcid":"https://orcid.org/0000-0002-3773-6818"},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang Chang","raw_affiliation_strings":["Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA","Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Department of Electrical and Biomedical Engineering, University of Nevada, Reno, Nevada, USA","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4416,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.78548334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"113","issue":null,"first_page":"1025","last_page":"1028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6383074522018433},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.571973443031311},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.5252510905265808},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.5163737535476685},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4896100163459778},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4464796483516693},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.42272454500198364},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.41817986965179443},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.41510075330734253},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3496437668800354},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3421764373779297},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3272148668766022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32082900404930115},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.28677648305892944},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1468508541584015}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6383074522018433},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.571973443031311},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5252510905265808},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5163737535476685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4896100163459778},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4464796483516693},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42272454500198364},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.41817986965179443},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41510075330734253},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3496437668800354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3421764373779297},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3272148668766022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32082900404930115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28677648305892944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1468508541584015}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/isbi.2016.7493440","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493440","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:27390615","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27390615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt51t5t0ws","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/51t5t0ws","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4932846","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},{"id":"pmh:qt51t5t0ws","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/51t5t0ws","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Han, J; Fontenay, GV; Wang, Y; Mao, JH; &amp; Chang, H. (2016). Phenotypic characterization of breast invasive carcinoma via transferable tissue morphometric patterns learned from glioblastoma multiforme. Proceedings - International Symposium on Biomedical Imaging, 2016-June, 1025 - 1028. doi: 10.1109/ISBI.2016.7493440. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/51t5t0ws","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4932846","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G5597776480","display_name":null,"funder_award_id":"R01 CA184476","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338292","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1548779692","https://openalex.org/W1573167384","https://openalex.org/W1903446459","https://openalex.org/W1990904097","https://openalex.org/W2001810343","https://openalex.org/W2005816532","https://openalex.org/W2014676949","https://openalex.org/W2027589906","https://openalex.org/W2029075222","https://openalex.org/W2031867580","https://openalex.org/W2044702943","https://openalex.org/W2096283457","https://openalex.org/W2103243046","https://openalex.org/W2109770548","https://openalex.org/W2113606819","https://openalex.org/W2114289955","https://openalex.org/W2124771137","https://openalex.org/W2130410032","https://openalex.org/W2133257461","https://openalex.org/W2133605685","https://openalex.org/W2133866056","https://openalex.org/W2134563198","https://openalex.org/W2139480020","https://openalex.org/W2143055991","https://openalex.org/W2150506962","https://openalex.org/W2152315187","https://openalex.org/W2171490498","https://openalex.org/W2172174689","https://openalex.org/W2560367415","https://openalex.org/W4293652559","https://openalex.org/W6676903177","https://openalex.org/W6679718588","https://openalex.org/W6679809621","https://openalex.org/W6685191590"],"related_works":["https://openalex.org/W4307993920","https://openalex.org/W1898241694","https://openalex.org/W2041783360","https://openalex.org/W4390695629","https://openalex.org/W2036616013","https://openalex.org/W3157307916","https://openalex.org/W2141091415","https://openalex.org/W2786822253","https://openalex.org/W2895456557","https://openalex.org/W2101753987"],"abstract_inverted_index":{"Quantitative":[0],"analysis":[1,137],"of":[2,15,21,30,78,88,106,138,144],"whole":[3],"slide":[4],"images":[5],"(WSIs)":[6],"in":[7,49,61,149,156],"a":[8,28,50,58,92],"large":[9,31,51],"cohort":[10],"may":[11],"provide":[12],"predictive":[13],"models":[14],"clinical":[16],"outcome.":[17],"However,":[18],"the":[19,22,76,86,102,110],"performance":[20],"existing":[23],"techniques":[24],"is":[25],"hindered":[26],"as":[27],"result":[29],"technical":[32],"variations":[33],"(e.g.,":[34,40],"fixation,":[35],"staining)":[36],"and":[37,104,153],"biological":[38],"heterogeneities":[39],"cell":[41,43],"type,":[42],"state)":[44],"that":[45],"are":[46],"always":[47],"present":[48],"cohort.":[52,119],"Although":[53],"unsupervised":[54],"feature":[55],"learning":[56,62],"provides":[57],"promising":[59],"way":[60],"pertinent":[63],"features":[64],"without":[65],"human":[66],"intervention,":[67],"its":[68,99],"capability":[69],"can":[70],"be":[71],"greatly":[72],"limited":[73],"due":[74],"to":[75,101,151,158],"lack":[77],"well-curated":[79,93],"examples.":[80],"In":[81],"this":[82],"paper,":[83],"we":[84],"explored":[85],"transferability":[87],"knowledge":[89],"acquired":[90],"from":[91,109],"Glioblastoma":[94],"Multiforme":[95],"(GBM)":[96],"dataset":[97],"through":[98],"application":[100],"representation":[103],"characterization":[105],"tissue":[107],"histology":[108],"Cancer":[111],"Genome":[112],"Atlas":[113],"(TCGA)":[114],"Breast":[115],"Invasive":[116],"Carcinoma":[117],"(BRCA)":[118],"Our":[120],"experimental":[121],"results":[122],"reveals":[123],"two":[124,140],"major":[125],"phenotypic":[126],"subtypes":[127,141],"with":[128],"statistically":[129],"significantly":[130],"different":[131],"survival":[132],"curves.":[133],"Further":[134],"differential":[135],"expression":[136],"these":[139],"indicates":[142],"enrichment":[143],"genes":[145,154],"regulated":[146],"by":[147],"NF-kB":[148],"response":[150,157],"TNF":[152],"up-regulated":[155],"IFNG.":[159]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
