{"id":"https://openalex.org/W2423467081","doi":"https://doi.org/10.1109/isbi.2016.7493356","title":"A linear measure of F\u00f6rster resonant energy transfer (FRET) efficiency incorporating a shot noise uncertainty model for fluorescence microscopy intensity images","display_name":"A linear measure of F\u00f6rster resonant energy transfer (FRET) efficiency incorporating a shot noise uncertainty model for fluorescence microscopy intensity images","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2423467081","doi":"https://doi.org/10.1109/isbi.2016.7493356","mag":"2423467081"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493356","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493356","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082860777","display_name":"Mark A. Holden","orcid":"https://orcid.org/0000-0003-3060-7615"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Mark Holden","raw_affiliation_strings":["Institute of Electronics, National Chiao Tung University, Hsinchu, Taiwan","TECD-Westinghouse Motor Company, Round Rock, TX, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Electronics, National Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"TECD-Westinghouse Motor Company, Round Rock, TX, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082860777"],"corresponding_institution_ids":["https://openalex.org/I148366613"],"apc_list":null,"apc_paid":null,"fwci":0.4821,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83952242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"672","last_page":"675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f\u00f6rster-resonance-energy-transfer","display_name":"F\u00f6rster resonance energy transfer","score":0.9100202322006226},{"id":"https://openalex.org/keywords/shot-noise","display_name":"Shot noise","score":0.6844432353973389},{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.5405792593955994},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4897482395172119},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.45423904061317444},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.42814725637435913},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.37407898902893066},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.36083364486694336},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3322165012359619},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21483519673347473},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.15364959836006165},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1420806348323822},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.07537543773651123}],"concepts":[{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.9100202322006226},{"id":"https://openalex.org/C72659945","wikidata":"https://www.wikidata.org/wiki/Q1503574","display_name":"Shot noise","level":3,"score":0.6844432353973389},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.5405792593955994},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4897482395172119},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.45423904061317444},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.42814725637435913},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.37407898902893066},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36083364486694336},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3322165012359619},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21483519673347473},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.15364959836006165},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1420806348323822},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.07537543773651123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2016.7493356","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493356","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.9100000262260437}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1968176683","https://openalex.org/W1990346395","https://openalex.org/W2068924803","https://openalex.org/W2077502289","https://openalex.org/W2084312697","https://openalex.org/W2094517427","https://openalex.org/W2108855378","https://openalex.org/W2113974479","https://openalex.org/W2114336941","https://openalex.org/W2168237413","https://openalex.org/W4230350617","https://openalex.org/W4401328540"],"related_works":["https://openalex.org/W2146292829","https://openalex.org/W1547421146","https://openalex.org/W2914628622","https://openalex.org/W2413412399","https://openalex.org/W1964857975","https://openalex.org/W3005327985","https://openalex.org/W2367453728","https://openalex.org/W2901116005","https://openalex.org/W2032124327","https://openalex.org/W2810410904"],"abstract_inverted_index":{"We":[0,86],"propose":[1],"a":[2,52,66,80],"linear":[3],"measure":[4,30,68,122],"of":[5,39,44,55,69,72,83],"the":[6,26,40,70,110],"F\u00f6rster":[7],"resonant":[8],"energy":[9],"transfer":[10],"(FRET)":[11],"efficiency":[12],"derived":[13],"in":[14],"joint,":[15],"donor":[16],"and":[17,21,58,98,112,123],"acceptor,":[18],"intensity":[19],"space":[20],"compare":[22],"it":[23,60],"quantitatively":[24,90],"with":[25,61,101],"conventional":[27],"ratiometric":[28],"FRET":[29,34,73,84,102,120],"normally":[31],"used":[32,78],"for":[33],"fluorescence":[35],"microscopy":[36],"images.":[37,85],"Because":[38],"low":[41],"signal-to-noise":[42],"characteristic":[43],"these":[45],"images,":[46,49],"particularly":[47],"time-lapse":[48],"we":[50],"determine":[51],"quantitative":[53],"model":[54],"shot":[56,107],"noise":[57,108],"combine":[59],"our":[62,88,119],"measure.":[63],"This":[64],"provides":[65],"single":[67],"certainty":[71,121],"events":[74],"that":[75],"can":[76],"be":[77],"as":[79],"pixel-wise":[81],"classifier":[82],"evaluate":[87],"measures":[89],"by":[91],"simulating":[92],"photon":[93],"emission":[94],"under":[95],"realistic":[96],"conditions":[97],"demonstrate:":[99],"linearity":[100],"efficiency;":[103],"less":[104],"bias":[105],"to":[106],"than":[109],"ratio;":[111],"high":[113],"correlation":[114],"(r":[115],"=":[116],"0.96)":[117],"between":[118],"SNR.":[124]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
