{"id":"https://openalex.org/W2444555039","doi":"https://doi.org/10.1109/isbi.2016.7493327","title":"Structure-based assessment of cancerous mitochondria using deep networks","display_name":"Structure-based assessment of cancerous mitochondria using deep networks","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2444555039","doi":"https://doi.org/10.1109/isbi.2016.7493327","mag":"2444555039"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493327","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493327","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103042846","display_name":"Manish Mishra","orcid":"https://orcid.org/0000-0002-1471-0682"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Manish Mishra","raw_affiliation_strings":["Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany"],"affiliations":[{"raw_affiliation_string":"Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046916986","display_name":"Sabine Schmitt","orcid":null},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Schmitt","raw_affiliation_strings":["Helmholtz Zentrum Muenchen, Institute for Molecular Toxicology and Pharmacology, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute for Molecular Toxicology and Pharmacology, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114549796","display_name":"Lichao Wang","orcid":"https://orcid.org/0009-0005-0426-5924"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lichao Wang","raw_affiliation_strings":["Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany"],"affiliations":[{"raw_affiliation_string":"Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058683692","display_name":"Michael Strasser","orcid":"https://orcid.org/0000-0001-8512-6814"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael K. Strasser","raw_affiliation_strings":["Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046721596","display_name":"Carsten Marr","orcid":"https://orcid.org/0000-0003-2154-4552"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Marr","raw_affiliation_strings":["Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046896448","display_name":"Nassir Navab","orcid":"https://orcid.org/0000-0002-6032-5611"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nassir Navab","raw_affiliation_strings":["Computer Aided Medical Procedures (CAMP), Johns Hopkins University, USA","Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany"],"affiliations":[{"raw_affiliation_string":"Computer Aided Medical Procedures (CAMP), Johns Hopkins University, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042757354","display_name":"Hans Zischka","orcid":"https://orcid.org/0000-0002-4047-1566"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Zischka","raw_affiliation_strings":["Helmholtz Zentrum Muenchen, Institute for Molecular Toxicology and Pharmacology, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute for Molecular Toxicology and Pharmacology, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070636207","display_name":"Tingying Peng","orcid":"https://orcid.org/0000-0002-7881-1749"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tingying Peng","raw_affiliation_strings":["Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany"],"affiliations":[{"raw_affiliation_string":"Computer Aided Medical Procedures (CAMP), Technische Universitaet Muenchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Helmholtz Zentrum Muenchen, Institute of Computational Biology (ICB), Germany","institution_ids":["https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5103042846"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":0.6681,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73082518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"545","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.8402911424636841},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.795025110244751},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.48303279280662537},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4528138041496277},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44672074913978577},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"Cancer cell lines","score":0.42497682571411133},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4138805866241455},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40781858563423157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40550485253334045},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4049557149410248},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4041544198989868},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37883561849594116},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.31693118810653687},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14750298857688904},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10717910528182983}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8402911424636841},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.795025110244751},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48303279280662537},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4528138041496277},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44672074913978577},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.42497682571411133},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4138805866241455},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40781858563423157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40550485253334045},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4049557149410248},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4041544198989868},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37883561849594116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31693118810653687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14750298857688904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10717910528182983}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2016.7493327","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493327","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:49296","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49296","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: Proceedings (Proceedings / IEEE 13th International Symposium on Biomedical Imaging (ISBI), 13-16 April 2016, Prague, Czech Republic). IEEE, 2016.","raw_type":""},{"id":"pmh:oai:push-zb.helmholtz-munich.de:49296","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=49296","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In:. IEEE, 2016.","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W222722817","https://openalex.org/W1601795611","https://openalex.org/W1994803892","https://openalex.org/W2056476121","https://openalex.org/W2074297921","https://openalex.org/W2163605009","https://openalex.org/W2415033991","https://openalex.org/W2919115771","https://openalex.org/W2953066166","https://openalex.org/W4210273716","https://openalex.org/W6684191040","https://openalex.org/W6764750447"],"related_works":["https://openalex.org/W2087900954","https://openalex.org/W2444555039","https://openalex.org/W2120018986","https://openalex.org/W1988393794","https://openalex.org/W2298093885","https://openalex.org/W2066796216","https://openalex.org/W2060307699","https://openalex.org/W3040425006","https://openalex.org/W2071888273","https://openalex.org/W1972865454"],"abstract_inverted_index":{"Mitochondrial":[0],"functions":[1],"are":[2],"essential":[3],"for":[4],"cell":[5,54,76,93],"survival.":[6],"Pathologic":[7],"situations,":[8],"e.g.":[9],"cancer,":[10],"can":[11],"impair":[12],"mitochondrial":[13,28],"function":[14],"which":[15,78,95],"is":[16,86],"frequently":[17],"reflected":[18],"by":[19],"an":[20],"altered":[21],"morphology.":[22],"So":[23],"far,":[24],"feature":[25],"description":[26],"of":[27,48],"structure":[29,47],"in":[30],"cancer":[31],"remains":[32],"largely":[33],"qualitative.":[34],"In":[35],"this":[36],"study,":[37],"we":[38],"propose":[39],"a":[40,63],"learning-based":[41],"approach":[42],"to":[43,89,100,108],"quantitatively":[44],"assess":[45],"the":[46,79,102],"mitochondria":[49,69],"isolated":[50,68],"from":[51,70,106],"liver":[52],"tumor":[53,75,92,109],"lines":[55,77],"using":[56],"convolutional":[57],"neural":[58],"network":[59],"(CNN).":[60],"Besides":[61],"achieving":[62],"high":[64],"classification":[65],"accuracy":[66],"on":[67],"healthy":[71,107],"tissue":[72],"and":[73],"different":[74],"CNN":[80,85],"model":[81],"was":[82],"trained":[83],"on,":[84],"also":[87],"able":[88],"classify":[90],"unseen":[91],"lines,":[94],"suggests":[96],"its":[97],"superior":[98],"capability":[99],"capture":[101],"intrinsic":[103],"structural":[104],"transition":[105],"mitochondria.":[110]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-03-02T08:37:19.008085","created_date":"2025-10-10T00:00:00"}
