{"id":"https://openalex.org/W2442911556","doi":"https://doi.org/10.1109/isbi.2016.7493281","title":"FASP: A machine learning approach to functional astrocyte phenotyping from time-lapse calcium imaging data","display_name":"FASP: A machine learning approach to functional astrocyte phenotyping from time-lapse calcium imaging data","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2442911556","doi":"https://doi.org/10.1109/isbi.2016.7493281","mag":"2442911556"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493281","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493281","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040372961","display_name":"Yinxue Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinxue Wang","raw_affiliation_strings":["Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102340509","display_name":"Guilai Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guilai Shi","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101739086","display_name":"David J. Miller","orcid":"https://orcid.org/0000-0001-8848-1643"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Miller","raw_affiliation_strings":["Department of Electrical Engineering, Pennsylvania State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Pennsylvania State University, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668418","display_name":"Yizhi Wang","orcid":"https://orcid.org/0000-0001-9456-0743"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yizhi Wang","raw_affiliation_strings":["Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009751100","display_name":"Gerard Joey Broussard","orcid":"https://orcid.org/0000-0003-1636-2615"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard Broussard","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372002","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-1788-1102"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080490976","display_name":"Lin Tian","orcid":"https://orcid.org/0000-0001-7012-6926"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Tian","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076006520","display_name":"Guoqiang Yu","orcid":"https://orcid.org/0000-0002-6743-7413"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoqiang Yu","raw_affiliation_strings":["Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"351","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6070197820663452},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5811909437179565},{"id":"https://openalex.org/keywords/astrocyte","display_name":"Astrocyte","score":0.5382058620452881},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.49286437034606934},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.4772239029407501},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.38025158643722534},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.22639742493629456},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2096826732158661}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6070197820663452},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5811909437179565},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5382058620452881},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49286437034606934},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.4772239029407501},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38025158643722534},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.22639742493629456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2096826732158661},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2016.7493281","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493281","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1973361488","https://openalex.org/W1995254774","https://openalex.org/W1995360097","https://openalex.org/W2047423254","https://openalex.org/W2054079425","https://openalex.org/W2069498125","https://openalex.org/W2076310752","https://openalex.org/W2094045132","https://openalex.org/W2106924853","https://openalex.org/W2107617294","https://openalex.org/W2123480521","https://openalex.org/W2136994190","https://openalex.org/W2504767107","https://openalex.org/W6678432778"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W3107602296","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"We":[0,135,175],"propose":[1],"a":[2],"machine":[3],"learning":[4],"approach":[5],"to":[6,91,108,112,122,132,141],"characterize":[7],"the":[8,13,70,84,97,123,150,177],"functional":[9],"status":[10],"of":[11,78,126,179],"astrocytes,":[12,117],"most":[14],"abundant":[15],"cells":[16],"in":[17,28,44,55,96,116,154],"human":[18],"brain,":[19],"based":[20],"on":[21,68,181],"time-lapse":[22,71],"Ca2+":[23,31,62,114,127],"imaging":[24,72],"data.":[25,101],"The":[26],"interest":[27],"analyzing":[29],"astrocyte":[30],"dynamics":[32],"is":[33,49,104,119,159],"evoked":[34],"by":[35,51],"recent":[36,52],"discoveries":[37],"that":[38],"astrocytes":[39],"play":[40],"proactive":[41],"regulatory":[42],"roles":[43],"neural":[45],"information":[46,94],"processing,":[47],"and":[48,58,74,129,148,161,169,184],"enabled":[50],"technical":[53],"advances":[54],"modern":[56],"microscopy":[57],"ultrasensitive":[59],"genetically":[60],"encoded":[61,95],"indicators.":[63],"However,":[64],"current":[65],"analysis":[66,85],"relies":[67],"eyeballing":[69],"data":[73,186],"manually":[75],"drawing":[76],"regions":[77],"interest,":[79],"which":[80,118],"not":[81],"only":[82],"limits":[83],"throughput":[86],"but":[87],"also":[88],"at":[89],"risk":[90],"miss":[92],"important":[93],"big":[98],"complex":[99,124,167],"dynamic":[100],"Thus,":[102],"there":[103],"an":[105,155],"increased":[106],"demand":[107],"develop":[109,136],"sophisticated":[110],"tools":[111],"dissect":[113],"signaling":[115,128],"challenging":[120],"due":[121],"nature":[125],"low":[130],"signal":[131],"noise":[133],"ratio.":[134],"Functional":[137],"AStrocyte":[138],"Phenotyping":[139],"(FASP)":[140],"automatically":[142],"detect":[143],"functionally":[144],"independent":[145],"units":[146],"(FIUs)":[147],"extract":[149],"corresponding":[151],"characteristic":[152],"curves":[153],"integrated":[156],"way.":[157],"FASP":[158,180],"data-driven":[160],"probabilistically":[162],"principled,":[163],"flexibly":[164],"accounts":[165],"for":[166],"patterns":[168],"accurately":[170],"controls":[171],"false":[172],"discovery":[173],"rates.":[174],"demonstrate":[176],"effectiveness":[178],"both":[182],"synthetic":[183],"real":[185],"sets.":[187]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}