{"id":"https://openalex.org/W2437089822","doi":"https://doi.org/10.1109/isbi.2016.7493280","title":"Dendritic spine shape analysis using disjunctive normal shape models","display_name":"Dendritic spine shape analysis using disjunctive normal shape models","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2437089822","doi":"https://doi.org/10.1109/isbi.2016.7493280","mag":"2437089822"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493280","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493280","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042506283","display_name":"Muhammad Usman Ghani","orcid":"https://orcid.org/0000-0002-6411-423X"},"institutions":[{"id":"https://openalex.org/I134235054","display_name":"Sabanc\u0131 \u00dcniversitesi","ror":"https://ror.org/049asqa32","country_code":"TR","type":"education","lineage":["https://openalex.org/I134235054"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muhammad Usman Ghani","raw_affiliation_strings":["Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey","institution_ids":["https://openalex.org/I134235054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072785230","display_name":"Fitsum Mesadi","orcid":"https://orcid.org/0000-0002-8458-2348"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fitsum Mesadi","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004914972","display_name":"S\u00fcmeyra Demir Kan\u0131k","orcid":"https://orcid.org/0000-0001-5976-0993"},"institutions":[{"id":"https://openalex.org/I134235054","display_name":"Sabanc\u0131 \u00dcniversitesi","ror":"https://ror.org/049asqa32","country_code":"TR","type":"education","lineage":["https://openalex.org/I134235054"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sumeyra Demir Kanik","raw_affiliation_strings":["Sabanci Universitesi, Istanbul, TR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sabanci Universitesi, Istanbul, TR","institution_ids":["https://openalex.org/I134235054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086123959","display_name":"Ali \u00d6zg\u00fcr Argun\u015fah","orcid":"https://orcid.org/0000-0002-3082-3775"},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ali Ozgur Argunsah","raw_affiliation_strings":["Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028230517","display_name":"Inbal Israely","orcid":"https://orcid.org/0000-0001-7234-6359"},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Inbal Israely","raw_affiliation_strings":["Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006754641","display_name":"Devrim \u00dcnay","orcid":"https://orcid.org/0000-0003-3478-7318"},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Devrim Unay","raw_affiliation_strings":["Faculty of Engineering and Computer Sciences, \u0130zmir University of Economics, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Computer Sciences, \u0130zmir University of Economics, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059125158","display_name":"Tolga Ta\u015fdizen","orcid":"https://orcid.org/0000-0001-6574-0366"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tolga Tasdizen","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017228370","display_name":"M\u00fcjdat \u00c7etin","orcid":"https://orcid.org/0000-0002-9824-1229"},"institutions":[{"id":"https://openalex.org/I134235054","display_name":"Sabanc\u0131 \u00dcniversitesi","ror":"https://ror.org/049asqa32","country_code":"TR","type":"education","lineage":["https://openalex.org/I134235054"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mujdat Cetin","raw_affiliation_strings":["Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey","institution_ids":["https://openalex.org/I134235054"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1608,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.75737967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"347","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shape-analysis","display_name":"Shape analysis (program analysis)","score":0.8213086724281311},{"id":"https://openalex.org/keywords/active-shape-model","display_name":"Active shape model","score":0.7290496826171875},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6741403341293335},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6570905447006226},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6536102890968323},{"id":"https://openalex.org/keywords/heat-kernel-signature","display_name":"Heat kernel signature","score":0.6249504685401917},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6099807024002075},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.6084793210029602},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5697168111801147},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.557604193687439},{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.5050037503242493},{"id":"https://openalex.org/keywords/shape-context","display_name":"Shape context","score":0.4830135107040405},{"id":"https://openalex.org/keywords/topological-skeleton","display_name":"Topological skeleton","score":0.4787822961807251},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.452430784702301},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4498346745967865},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.4249945282936096},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4248029589653015},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24695324897766113},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.15328067541122437}],"concepts":[{"id":"https://openalex.org/C112604564","wikidata":"https://www.wikidata.org/wiki/Q7489226","display_name":"Shape analysis (program analysis)","level":3,"score":0.8213086724281311},{"id":"https://openalex.org/C129641003","wikidata":"https://www.wikidata.org/wiki/Q267189","display_name":"Active shape model","level":3,"score":0.7290496826171875},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6741403341293335},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6570905447006226},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6536102890968323},{"id":"https://openalex.org/C45089102","wikidata":"https://www.wikidata.org/wiki/Q5693286","display_name":"Heat kernel signature","level":4,"score":0.6249504685401917},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6099807024002075},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.6084793210029602},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5697168111801147},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.557604193687439},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.5050037503242493},{"id":"https://openalex.org/C2779662243","wikidata":"https://www.wikidata.org/wiki/Q970395","display_name":"Shape context","level":3,"score":0.4830135107040405},{"id":"https://openalex.org/C112785775","wikidata":"https://www.wikidata.org/wiki/Q786441","display_name":"Topological skeleton","level":4,"score":0.4787822961807251},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.452430784702301},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4498346745967865},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.4249945282936096},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4248029589653015},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24695324897766113},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.15328067541122437},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C97686452","wikidata":"https://www.wikidata.org/wiki/Q7604153","display_name":"Static analysis","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2016.7493280","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493280","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:research.sabanciuniv.edu:29329","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402254","display_name":"Sabanci University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134235054","host_organization_name":"Sabanc\u0131 \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I134235054"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Papers in Conference Proceedings"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1550911063","https://openalex.org/W1592074189","https://openalex.org/W1605094393","https://openalex.org/W1975782461","https://openalex.org/W2003493421","https://openalex.org/W2042204212","https://openalex.org/W2048452708","https://openalex.org/W2095782854","https://openalex.org/W2130044532","https://openalex.org/W2137979527","https://openalex.org/W2145768048","https://openalex.org/W2257644880","https://openalex.org/W2298636840","https://openalex.org/W6679507437","https://openalex.org/W6692195741","https://openalex.org/W6698009033"],"related_works":["https://openalex.org/W2736624805","https://openalex.org/W2143519535","https://openalex.org/W2559823020","https://openalex.org/W2501097992","https://openalex.org/W4292771328","https://openalex.org/W2725428154","https://openalex.org/W2255095663","https://openalex.org/W2086074953","https://openalex.org/W1566479180","https://openalex.org/W3142624072"],"abstract_inverted_index":{"Analysis":[0],"of":[1,13,107,135,152],"dendritic":[2,95],"spines":[3],"is":[4,54],"an":[5],"essential":[6],"task":[7],"to":[8,20,35,62,131,146],"understand":[9],"the":[10,115,133,140,150,153],"functional":[11],"behavior":[12],"neurons.":[14],"Their":[15],"shape":[16,28,41,57,76,137,154],"variations":[17],"are":[18],"known":[19],"be":[21,63],"closely":[22],"linked":[23],"with":[24],"neuronal":[25],"activities.":[26],"Spine":[27],"analysis":[29,155],"in":[30,65,139,157],"particular,":[31],"can":[32],"assist":[33],"neuroscientists":[34],"identify":[36],"this":[37,70,74,158],"relationship.":[38],"A":[39],"novel":[40],"representation":[42,58,77],"has":[43,60],"been":[44],"proposed":[45,101],"recently,":[46],"called":[47],"Disjunctive":[48],"Normal":[49],"Shape":[50],"Models":[51],"(DNSM).":[52],"DNSM":[53],"a":[55,79,86,104,129],"parametric":[56,75],"and":[59,110],"proven":[61],"successful":[64],"several":[66],"segmentation":[67],"problems.":[68],"In":[69],"paper,":[71],"we":[72,84],"apply":[73],"as":[78],"feature":[80,118],"extraction":[81],"algorithm.":[82],"Further,":[83],"propose":[85],"kernel":[87],"density":[88],"estimation":[89],"(KDE)":[90],"based":[91,119],"classification":[92],"approach":[93,102,120],"for":[94,121],"spine":[96,122,136],"classification.":[97,123],"We":[98],"evaluate":[99],"our":[100],"on":[103],"data":[105],"set":[106],"242":[108],"spines,":[109],"observe":[111],"that":[112],"it":[113],"outperforms":[114],"classical":[116],"morphological":[117],"Our":[124],"probabilistic":[125],"framework":[126],"also":[127],"provides":[128],"way":[130],"examine":[132],"separability":[134],"classes":[138],"likelihood":[141],"ratio":[142],"space,":[143],"which":[144],"leads":[145],"further":[147],"insights":[148],"about":[149],"nature":[151],"problem":[156],"context.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}