{"id":"https://openalex.org/W2440104083","doi":"https://doi.org/10.1109/isbi.2016.7493276","title":"Automatic detection of neurons in high-content microscope images using machine learning approaches","display_name":"Automatic detection of neurons in high-content microscope images using machine learning approaches","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2440104083","doi":"https://doi.org/10.1109/isbi.2016.7493276","mag":"2440104083"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493276","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036169141","display_name":"Gadea Mata","orcid":"https://orcid.org/0000-0002-5567-8463"},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Gadea Mata","raw_affiliation_strings":["Departamento de Matem\u00e1ticas y Computaci\u00f3n, Universidad de La Rioja, Spain"],"affiliations":[{"raw_affiliation_string":"Departamento de Matem\u00e1ticas y Computaci\u00f3n, Universidad de La Rioja, Spain","institution_ids":["https://openalex.org/I168974976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069090518","display_name":"Miroslav Radojevi\u0107","orcid":"https://orcid.org/0000-0003-4480-1232"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Miroslav Radojevic","raw_affiliation_strings":["Erasmus University Medical Center, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026507016","display_name":"Ihor Smal","orcid":"https://orcid.org/0000-0001-7576-7028"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ihor Smal","raw_affiliation_strings":["Erasmus University Medical Center, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013057115","display_name":"Miguel Morales","orcid":"https://orcid.org/0000-0002-8885-2333"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Morales","raw_affiliation_strings":["Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023548565","display_name":"Erik Meijering","orcid":"https://orcid.org/0000-0001-8015-8358"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik Meijering","raw_affiliation_strings":["Erasmus University Medical Center, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034271146","display_name":"Julio Rubio","orcid":"https://orcid.org/0000-0002-4282-3692"},"institutions":[{"id":"https://openalex.org/I168974976","display_name":"Universidad de La Rioja","ror":"https://ror.org/0553yr311","country_code":"ES","type":"education","lineage":["https://openalex.org/I168974976"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio Rubio","raw_affiliation_strings":["Departamento de Matem\u00e1ticas y Computaci\u00f3n, Universidad de La Rioja, Spain"],"affiliations":[{"raw_affiliation_string":"Departamento de Matem\u00e1ticas y Computaci\u00f3n, Universidad de La Rioja, Spain","institution_ids":["https://openalex.org/I168974976"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5036169141"],"corresponding_institution_ids":["https://openalex.org/I168974976"],"apc_list":null,"apc_paid":null,"fwci":2.4104,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90716374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"99","issue":null,"first_page":"330","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.796431303024292},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7801473140716553},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.691802442073822},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5804370641708374},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.5780825614929199},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5379669070243835},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.5191113948822021},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4949466586112976},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4800654351711273},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.4439865052700043},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.432503879070282},{"id":"https://openalex.org/keywords/content","display_name":"Content (measure theory)","score":0.42937564849853516},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.42454084753990173},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09837156534194946}],"concepts":[{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.796431303024292},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7801473140716553},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.691802442073822},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5804370641708374},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.5780825614929199},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5379669070243835},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.5191113948822021},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4949466586112976},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4800654351711273},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.4439865052700043},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.432503879070282},{"id":"https://openalex.org/C2778152352","wikidata":"https://www.wikidata.org/wiki/Q5165061","display_name":"Content (measure theory)","level":2,"score":0.42937564849853516},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.42454084753990173},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09837156534194946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2016.7493276","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W145108504","https://openalex.org/W160351337","https://openalex.org/W1966570479","https://openalex.org/W1972552638","https://openalex.org/W1984214648","https://openalex.org/W1988878611","https://openalex.org/W2003357296","https://openalex.org/W2009086942","https://openalex.org/W2021094532","https://openalex.org/W2057418611","https://openalex.org/W2085596800","https://openalex.org/W2099540110","https://openalex.org/W2103658758","https://openalex.org/W2107326450","https://openalex.org/W2133990480","https://openalex.org/W2141626980","https://openalex.org/W2145023731","https://openalex.org/W2151103935","https://openalex.org/W2156012604","https://openalex.org/W4313152550"],"related_works":["https://openalex.org/W1542224353","https://openalex.org/W1661087619","https://openalex.org/W2116854923","https://openalex.org/W2750730210","https://openalex.org/W2236974868","https://openalex.org/W4312766348","https://openalex.org/W4233939244","https://openalex.org/W2730764323","https://openalex.org/W3123806511","https://openalex.org/W1976727107"],"abstract_inverted_index":{"The":[0,57,106],"study":[1],"of":[2,15,43,49,66,80],"neuronal":[3],"cell":[4],"morphology":[5],"and":[6,22,91,93,116],"function":[7],"in":[8,40,60,69],"relation":[9],"to":[10,98],"neurological":[11],"disease":[12],"processes":[13],"is":[14,63],"high":[16],"importance":[17],"for":[18,29],"developing":[19],"suitable":[20],"drugs":[21],"therapies.":[23],"To":[24],"accelerate":[25],"discovery,":[26],"biological":[27],"experiments":[28],"this":[30,61,74],"purpose":[31],"are":[32,55],"increasingly":[33],"scaled":[34],"up":[35],"using":[36],"high-content":[37,71],"screening,":[38],"resulting":[39],"vast":[41],"amounts":[42],"image":[44],"data.":[45],"For":[46],"the":[47,64,70,78,112],"analysis":[48],"these":[50],"data":[51],"fully":[52],"automatic":[53],"methods":[54,121],"needed.":[56],"first":[58],"step":[59],"process":[62],"detection":[65,84,125],"neuron":[67],"regions":[68],"images.":[72],"In":[73],"paper":[75],"we":[76,94],"investigate":[77],"potential":[79],"two":[81],"machine-learning":[82,119],"based":[83,86,102,120],"approaches":[85],"on":[87,103],"different":[88],"feature":[89,114],"sets":[90],"classifiers":[92],"compare":[95],"their":[96],"performance":[97],"an":[99],"alternative":[100],"method":[101],"hysteresis":[104],"thresholding.":[105],"experimental":[107],"results":[108],"indicate":[109],"that":[110],"with":[111],"right":[113],"set":[115],"training":[117],"procedure,":[118],"may":[122],"yield":[123],"superior":[124],"performance.":[126]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
