{"id":"https://openalex.org/W2441509556","doi":"https://doi.org/10.1109/isbi.2016.7493253","title":"Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration","display_name":"Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2441509556","doi":"https://doi.org/10.1109/isbi.2016.7493253","mag":"2441509556"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2016.7493253","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493253","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/files/178266875/Network-attack-simulations-in-alzheimers-disease.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063326468","display_name":"Matteo Mancini","orcid":"https://orcid.org/0000-0001-7194-4568"},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Matteo Mancini","raw_affiliation_strings":["Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","institution_ids":["https://openalex.org/I119003972"]},{"raw_affiliation_string":"Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084092338","display_name":"Marcel A. de Reus","orcid":null},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel A. de Reus","raw_affiliation_strings":["Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060367347","display_name":"Laura Serra","orcid":"https://orcid.org/0000-0002-2717-1286"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Serra","raw_affiliation_strings":["Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078205854","display_name":"Marco Bozzali","orcid":"https://orcid.org/0000-0002-0568-2026"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Bozzali","raw_affiliation_strings":["Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009949271","display_name":"Martijn P. van den Heuvel","orcid":"https://orcid.org/0000-0003-1570-1195"},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martijn P. van den Heuvel","raw_affiliation_strings":["Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","institution_ids":["https://openalex.org/I119003972"]},{"raw_affiliation_string":"Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032032723","display_name":"Mara Cercignani","orcid":"https://orcid.org/0000-0002-4550-2456"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I100063501","display_name":"Brighton and Sussex Medical School","ror":"https://ror.org/01qz7fr76","country_code":"GB","type":"education","lineage":["https://openalex.org/I100063501","https://openalex.org/I162608824","https://openalex.org/I71637028"]},{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Mara Cercignani","raw_affiliation_strings":["Brighton & Sussex Medical School, University of Sussex, Brighton, United Kingdom","Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Brighton & Sussex Medical School, University of Sussex, Brighton, United Kingdom","institution_ids":["https://openalex.org/I100063501","https://openalex.org/I162608824"]},{"raw_affiliation_string":"Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041313475","display_name":"Silvia Conforto","orcid":"https://orcid.org/0000-0001-7323-5220"},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Conforto","raw_affiliation_strings":["Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Rome \u201cRoma Tre\u201d, Rome, Italy","institution_ids":["https://openalex.org/I119003972"]},{"raw_affiliation_string":"Department of Engineering, University of Rome \"Roma Tre\", Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5063326468"],"corresponding_institution_ids":["https://openalex.org/I119003972"],"apc_list":null,"apc_paid":null,"fwci":0.9971,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75328028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"31","issue":null,"first_page":"237","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5968765616416931},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5769205093383789},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.5536266565322876},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.5535861253738403},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5411137938499451},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.5080878734588623},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.47181737422943115},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.46399709582328796},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.3526087999343872},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.34735745191574097},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33677423000335693},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.2818893492221832},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2341209352016449},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10881191492080688}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5968765616416931},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5769205093383789},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5536266565322876},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5535861253738403},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5411137938499451},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.5080878734588623},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47181737422943115},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.46399709582328796},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3526087999343872},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.34735745191574097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33677423000335693},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.2818893492221832},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2341209352016449},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10881191492080688},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi.2016.7493253","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2016.7493253","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/e8508d64-b6bb-498c-b3f5-a82d08994c0c","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e8508d64-b6bb-498c-b3f5-a82d08994c0c","pdf_url":"https://pure.amsterdamumc.nl/files/178266875/Network-attack-simulations-in-alzheimers-disease.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mancini, M, De Reus, M A, Serra, L, Bozzali, M, Van Den Heuvel, M P, Cercignani, M & Conforto, S 2016, Network attack simulations in Alzheimer's disease : The link between network tolerance and neurodegeneration. in 2016 IEEE International Symposium on Biomedical Imaging : From Nano to Macro, ISBI 2016 - Proceedings., 7493253, Proceedings - International Symposium on Biomedical Imaging, vol. 2016-June, IEEE Computer Society, pp. 237-240, 2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016, 15/06/2016. https://doi.org/10.1109/ISBI.2016.7493253","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.uniroma3.it:11590/306989","is_oa":false,"landing_page_url":"http://hdl.handle.net/11590/306989","pdf_url":null,"source":{"id":"https://openalex.org/S4377196120","display_name":"Iris (Roma Tre University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119003972","host_organization_name":"Roma Tre University","host_organization_lineage":["https://openalex.org/I119003972"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/a69ab803-b866-4a80-a84e-4c4bb64cfefa","is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/a69ab803-b866-4a80-a84e-4c4bb64cfefa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2016 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016 - Proceedings, 237 - 240","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/e8508d64-b6bb-498c-b3f5-a82d08994c0c","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e8508d64-b6bb-498c-b3f5-a82d08994c0c","pdf_url":"https://pure.amsterdamumc.nl/files/178266875/Network-attack-simulations-in-alzheimers-disease.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mancini, M, De Reus, M A, Serra, L, Bozzali, M, Van Den Heuvel, M P, Cercignani, M & Conforto, S 2016, Network attack simulations in Alzheimer's disease : The link between network tolerance and neurodegeneration. in 2016 IEEE International Symposium on Biomedical Imaging : From Nano to Macro, ISBI 2016 - Proceedings., 7493253, Proceedings - International Symposium on Biomedical Imaging, vol. 2016-June, IEEE Computer Society, pp. 237-240, 2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016, 15/06/2016. https://doi.org/10.1109/ISBI.2016.7493253","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5600000023841858}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2441509556.pdf"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1593588070","https://openalex.org/W1973412793","https://openalex.org/W1978450732","https://openalex.org/W1987924998","https://openalex.org/W1995876521","https://openalex.org/W1999653836","https://openalex.org/W2012559638","https://openalex.org/W2014030916","https://openalex.org/W2022891394","https://openalex.org/W2026593185","https://openalex.org/W2065769502","https://openalex.org/W2073433254","https://openalex.org/W2087938247","https://openalex.org/W2088905367","https://openalex.org/W2099797292","https://openalex.org/W2104841736","https://openalex.org/W2116083905","https://openalex.org/W2161493176","https://openalex.org/W2166905390","https://openalex.org/W2167822639","https://openalex.org/W2963615156","https://openalex.org/W3103071483"],"related_works":["https://openalex.org/W2794217300","https://openalex.org/W2764192351","https://openalex.org/W2965213848","https://openalex.org/W2102136350","https://openalex.org/W1886844647","https://openalex.org/W4313648027","https://openalex.org/W4323652623","https://openalex.org/W4327554146","https://openalex.org/W4308332022","https://openalex.org/W2903220633"],"abstract_inverted_index":{"The":[0],"brain":[1,24],"structure":[2],"is":[3,40],"a":[4,26],"complex":[5],"network":[6,54],"of":[7,17,61,133,141],"interconnected":[8],"regions":[9],"with":[10],"specific":[11,139],"topological":[12],"characteristics.":[13],"Since":[14],"the":[15,30,43,58,89,93,109,123,130],"disruption":[16],"this":[18,47,51],"infrastructure":[19],"has":[20],"been":[21],"linked":[22],"to":[23,29,41,85,113],"diseases,":[25],"key":[27],"element":[28],"quest":[31],"for":[32],"understanding":[33],"how":[34],"such":[35],"diseases":[36],"start":[37],"and":[38,68,73,82,87,101,116],"spread":[39],"outline":[42],"degenerative":[44],"pattern.":[45],"In":[46],"paper,":[48],"we":[49],"explored":[50],"aspect":[52],"using":[53],"attack":[55,80,105],"simulation":[56],"on":[57],"structural":[59],"connectomes":[60],"60":[62],"patients":[63,100],"among":[64],"Alzheimer's":[65,134],"disease":[66,135],"(AD)":[67],"mild":[69],"cognitive":[70],"impairment":[71],"(MCI)":[72],"30":[74],"healthy":[75],"subjects.":[76],"We":[77,96],"considered":[78],"different":[79,83,94],"strategies":[81],"metrics":[84],"evaluate":[86],"compare":[88],"induced":[90],"changes":[91],"between":[92],"groups.":[95],"found":[97],"out":[98],"that":[99,117,129],"controls":[102],"share":[103],"common":[104],"tolerance":[106,124],"patterns":[107],"in":[108,122],"peripheral":[110],"connections":[111],"compared":[112],"each":[114],"other,":[115],"hubs":[118],"played":[119],"analogous":[120],"role":[121],"impact.":[125],"These":[126],"results":[127],"suggest":[128],"spreading":[131],"pattern":[132],"does":[136],"not":[137],"target":[138],"class":[140],"regions.":[142]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-03-17T17:19:04.345684","created_date":"2025-10-10T00:00:00"}
