{"id":"https://openalex.org/W1483721262","doi":"https://doi.org/10.1109/isbi.2015.7164080","title":"Genetic analysis of structural brain connectivity using DICCCOL models of diffusion MRI in 522 twins","display_name":"Genetic analysis of structural brain connectivity using DICCCOL models of diffusion MRI in 522 twins","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1483721262","doi":"https://doi.org/10.1109/isbi.2015.7164080","mag":"1483721262","pmid":"https://pubmed.ncbi.nlm.nih.gov/26413210"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2015.7164080","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7164080","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.qut.edu.au/94878/14/94878.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038582366","display_name":"Dajiang Zhu","orcid":"https://orcid.org/0000-0002-6940-3911"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dajiang Zhu","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001309013","display_name":"Liang Zhan","orcid":"https://orcid.org/0000-0002-7920-4828"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Zhan","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005941814","display_name":"Joshua Faskowitz","orcid":"https://orcid.org/0000-0003-1814-7206"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Faskowitz","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069073490","display_name":"Madelaine Daianu","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madelaine Daianu","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036061196","display_name":"Greig I. de Zubicaray","orcid":"https://orcid.org/0000-0003-4506-0579"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Greig I. de Zubicaray","raw_affiliation_strings":["School of Psychology, University of Queensland, Brisbane, Australia","School of Psychology, University of Queensland Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychology, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Psychology, University of Queensland Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006318043","display_name":"Katie L. McMahon","orcid":"https://orcid.org/0000-0002-6357-615X"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210114492","display_name":"National Imaging Facility","ror":"https://ror.org/01kdbsa35","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210114492"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katie L. McMahon","raw_affiliation_strings":["Center for Advanced Imaging, University of Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Imaging, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I4210114492","https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012652688","display_name":"Nicholas G. Martin","orcid":"https://orcid.org/0000-0003-4069-8020"},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas G. Martin","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia","QIMR Berghofer, Medical Research Institute, Brisbane, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"QIMR Berghofer, Medical Research Institute, Brisbane, Australia;","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052245802","display_name":"Margaret J. Wright","orcid":"https://orcid.org/0000-0001-7133-4970"},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Margaret J. Wright","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Brisbane, Australia","QIMR Berghofer, Medical Research Institute, Brisbane, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"QIMR Berghofer, Medical Research Institute, Brisbane, Australia;","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Imaging Genetics Center, University of Southern California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, University of Southern California, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2015","issue":null,"first_page":"1167","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.6633721590042114},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5353057384490967},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.52394038438797},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.320059597492218},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2251397967338562},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11153021454811096},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1101149320602417}],"concepts":[{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.6633721590042114},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5353057384490967},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.52394038438797},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.320059597492218},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2251397967338562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11153021454811096},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1101149320602417},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi.2015.7164080","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7164080","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:26413210","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26413210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:eprints.qut.edu.au:94878","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.qut.edu.au/94878/14/94878.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI 2015)","raw_type":"Chapter in Book, Report or Conference volume"},{"id":"pmh:oai:pubmedcentral.nih.gov:4578156","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578156","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:eprints.qut.edu.au:94878","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.qut.edu.au/94878/14/94878.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI 2015)","raw_type":"Chapter in Book, Report or Conference volume"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G6230295091","display_name":null,"funder_award_id":"R01 HD050735","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7326523540","display_name":null,"funder_award_id":"U54 EB020403","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7862106776","display_name":null,"funder_award_id":"P41 EB015922","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1483721262.pdf"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1912948831","https://openalex.org/W1933931696","https://openalex.org/W1964802316","https://openalex.org/W1987653354","https://openalex.org/W1992990017","https://openalex.org/W1998594057","https://openalex.org/W1999816351","https://openalex.org/W2020797894","https://openalex.org/W2040769201","https://openalex.org/W2102521965","https://openalex.org/W2109434518","https://openalex.org/W2110065044","https://openalex.org/W2116668074","https://openalex.org/W2118347577","https://openalex.org/W2122173473","https://openalex.org/W2140054173","https://openalex.org/W2153283712","https://openalex.org/W2154054253","https://openalex.org/W2160371232","https://openalex.org/W2171251197","https://openalex.org/W6680797439"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"Genetic":[0],"and":[1,12,96],"environmental":[2,94],"factors":[3],"affect":[4],"white":[5,69],"matter":[6,70],"connectivity":[7,20,64,114,142],"in":[8,17,35,50,105],"the":[9,36,43,68,102],"normal":[10],"brain,":[11],"they":[13],"also":[14],"influence":[15],"diseases":[16],"which":[18],"brain":[19,30,106],"is":[21,24],"altered.":[22],"Little":[23],"known":[25],"about":[26],"genetic":[27,91,137],"influences":[28,138],"on":[29,139],"connectivity,":[31,49],"despite":[32],"wide":[33],"variations":[34,104],"brain's":[37],"neural":[38],"pathways.":[39],"Here":[40],"we":[41,81],"applied":[42],"\u201cDICCCOL\u201d":[44],"framework":[45],"to":[46,88],"analyze":[47],"structural":[48,85,141],"261":[51],"twin":[52],"pairs":[53],"(522":[54],"participants,":[55],"mean":[56],"age:":[57],"21.8":[58],"y":[59],"\u00b1":[60],"2.7SD).":[61],"We":[62,108],"encoded":[63],"patterns":[65],"by":[66],"projecting":[67],"(WM)":[71],"bundles":[72],"of":[73,101,124,136],"all":[74],"\u201cDICCCOLs\u201d":[75],"as":[76],"a":[77],"tracemap":[78],"(TM).":[79],"Next":[80],"fitted":[82],"an":[83],"A/C/E":[84],"equation":[86],"model":[87],"estimate":[89],"additive":[90],"(A),":[92],"common":[93],"(C),":[95],"unique":[97],"environmental/error":[98],"(E)":[99],"components":[100],"observed":[103],"connectivity.":[107],"found":[109],"44":[110],"\u201cheritable":[111],"DICCCOLs\u201d":[112],"whose":[113],"was":[115],"genetically":[116],"influenced":[117],"(\u03b1":[118,129],"<sup":[119,130],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[120,131],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[121,132],">1%);":[122],"half":[123],"them":[125],"showed":[126],"significant":[127],"heritability":[128,145],">20%).":[133],"Our":[134],"analysis":[135],"WM":[140,148],"suggests":[143],"high":[144],"for":[146,154],"some":[147],"projection":[149],"patterns,":[150],"yielding":[151],"new":[152],"targets":[153],"genome-wide":[155],"association":[156],"studies.":[157]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}