{"id":"https://openalex.org/W1480948843","doi":"https://doi.org/10.1109/isbi.2015.7163862","title":"Quantitative ultrasound spectroscopy and a kernel-based metric in clinical cancer response monitoring","display_name":"Quantitative ultrasound spectroscopy and a kernel-based metric in clinical cancer response monitoring","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1480948843","doi":"https://doi.org/10.1109/isbi.2015.7163862","mag":"1480948843"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2015.7163862","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031884787","display_name":"Mehrdad J. Gangeh","orcid":"https://orcid.org/0000-0002-2907-3014"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"M.J. Gangeh","raw_affiliation_strings":["Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044517600","display_name":"Hadi Tadayyon","orcid":null},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"H. Tadayyon","raw_affiliation_strings":["Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010501409","display_name":"Lakshmanan Sannachi","orcid":"https://orcid.org/0000-0002-9775-0224"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L. Sannachi","raw_affiliation_strings":["Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017745259","display_name":"Ali Sadeghi\u2010Naini","orcid":"https://orcid.org/0000-0001-5055-339X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Sadeghi-Naini","raw_affiliation_strings":["Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068273693","display_name":"Gregory J. Czarnota","orcid":"https://orcid.org/0000-0002-0519-2182"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G.J. Czarnota","raw_affiliation_strings":["Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology and Imaging Research, Sunnybrook Health Sciences Center, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031884787"],"corresponding_institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":1.9954,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.88336776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9034","issue":null,"first_page":"255","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.6156070232391357},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.5197279453277588},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4151558578014374},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3364294171333313},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2701006531715393},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14717280864715576},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.07339298725128174}],"concepts":[{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6156070232391357},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.5197279453277588},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4151558578014374},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3364294171333313},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2701006531715393},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14717280864715576},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.07339298725128174},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2015.7163862","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W47514981","https://openalex.org/W1638081485","https://openalex.org/W1892756525","https://openalex.org/W1966144743","https://openalex.org/W1970082212","https://openalex.org/W1989021837","https://openalex.org/W1991928026","https://openalex.org/W1995322777","https://openalex.org/W2019607817","https://openalex.org/W2026249247","https://openalex.org/W2040711614","https://openalex.org/W2062856359","https://openalex.org/W2101953144","https://openalex.org/W2114264989","https://openalex.org/W2125513860","https://openalex.org/W2130328119","https://openalex.org/W2140207058","https://openalex.org/W2152322845","https://openalex.org/W2159610922","https://openalex.org/W2162915993","https://openalex.org/W2166859022","https://openalex.org/W2169961966","https://openalex.org/W2212660284","https://openalex.org/W6601959561","https://openalex.org/W6636890744","https://openalex.org/W6660566126","https://openalex.org/W6688325169"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"a":[3,112,122,137,144,147,150],"metric":[4,114],"based":[5],"on":[6,66,159],"Hilbert-Schmidt":[7],"independence":[8],"criterion":[9],"(HSIC)":[10],"is":[11,146],"introduced":[12],"in":[13,25,136],"conjunction":[14],"with":[15,99],"quantitative":[16],"ultrasound":[17],"(QUS)":[18],"spectroscopy":[19],"methods":[20],"for":[21],"cancer":[22,29],"response":[23],"monitoring":[24],"locally":[26],"advanced":[27],"breast":[28],"(LABC)":[30],"patients":[31],"receiving":[32],"neoadjuvant":[33],"chemotherapy.":[34],"Midband":[35],"fit":[36],"spectral":[37],"parametric":[38,79,95,104],"maps":[39,80,105],"were":[40,47,75,97,126,134,157],"computed":[41,76],"using":[42,77,111],"QUS":[43],"radiofrequency":[44],"data,":[45],"which":[46,133,164],"obtained":[48,127,158],"from":[49,93,102],"56":[50],"LABC":[51],"patient":[52,145,176],"before":[53],"treatment":[54,110],"and":[55,70,130,155,162],"at":[56],"three":[57],"different":[58],"times":[59],"during":[60,106],"the":[61,83,86,90,103,107,167,174],"course":[62,108],"of":[63,73,109,118,181],"chemotherapy,":[64],"i.e.,":[65,89],"weeks":[67,160],"1,":[68],"4,":[69,163],"8.":[71],"Histograms":[72],"intensities":[74],"2D":[78],"to":[81,141],"represent":[82],"images.":[84],"Subsequently,":[85],"baseline":[87],"features,":[88],"features":[91],"extracted":[92,101],"\u201cpre-treatment\u201d":[94],"maps,":[96],"compared":[98],"those":[100],"kernel-based":[113],"as":[115],"an":[116],"indication":[117],"chemotherapy":[119],"effectiveness.":[120],"As":[121],"result,":[123],"dissimilarity":[124],"measures":[125],"between":[128,173],"\u201cpre-\u201d":[129],"\u201cduring-treatment\u201d":[131],"images,":[132],"used":[135],"supervised":[138],"learning":[139],"paradigm":[140],"estimate":[142],"whether":[143],"responder":[148],"or":[149],"non-responder.":[151],"High":[152],"accuracy,":[153],"sensitivity,":[154],"specificity":[156],"1":[161],"demonstrated":[165],"that":[166],"proposed":[168],"system":[169],"can":[170],"effectively":[171],"discriminate":[172],"two":[175],"populations":[177],"early":[178],"after":[179],"start":[180],"treatment.":[182]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
