{"id":"https://openalex.org/W1502768362","doi":"https://doi.org/10.1109/isbi.2015.7163830","title":"Parkinsonian differentiation using PCA image correlation scores","display_name":"Parkinsonian differentiation using PCA image correlation scores","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1502768362","doi":"https://doi.org/10.1109/isbi.2015.7163830","mag":"1502768362"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2015.7163830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091505277","display_name":"Phoebe G. Spetsieris","orcid":"https://orcid.org/0000-0001-7368-2354"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phoebe G. Spetsieris","raw_affiliation_strings":["Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030"],"affiliations":[{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]},{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074164462","display_name":"Vijay Dhawan","orcid":"https://orcid.org/0000-0002-2418-5674"},"institutions":[{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]},{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Dhawan","raw_affiliation_strings":["Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030"],"affiliations":[{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]},{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041539272","display_name":"David Eidelberg","orcid":"https://orcid.org/0000-0002-0854-864X"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I4210123128","display_name":"Center for Neurosciences","ror":"https://ror.org/03b5vk392","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123128"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eidelberg","raw_affiliation_strings":["Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030"],"affiliations":[{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset, NY","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]},{"raw_affiliation_string":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091505277"],"corresponding_institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210123128"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02871473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"118","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.7483441829681396},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.7111496329307556},{"id":"https://openalex.org/keywords/pearson-product-moment-correlation-coefficient","display_name":"Pearson product-moment correlation coefficient","score":0.6572067737579346},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6267954111099243},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.5637483596801758},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5338788032531738},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.528488278388977},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.510094940662384},{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.5085035562515259},{"id":"https://openalex.org/keywords/analysis-of-covariance","display_name":"Analysis of covariance","score":0.46153295040130615},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45135247707366943},{"id":"https://openalex.org/keywords/correlation-coefficient","display_name":"Correlation coefficient","score":0.4272492229938507},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4016774892807007},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3848055899143219},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33495986461639404},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.33452874422073364},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.20357266068458557},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.1918734908103943}],"concepts":[{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.7483441829681396},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.7111496329307556},{"id":"https://openalex.org/C55078378","wikidata":"https://www.wikidata.org/wiki/Q1136628","display_name":"Pearson product-moment correlation coefficient","level":2,"score":0.6572067737579346},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6267954111099243},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5637483596801758},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5338788032531738},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.528488278388977},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.510094940662384},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.5085035562515259},{"id":"https://openalex.org/C119340705","wikidata":"https://www.wikidata.org/wiki/Q1628597","display_name":"Analysis of covariance","level":2,"score":0.46153295040130615},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45135247707366943},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.4272492229938507},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4016774892807007},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3848055899143219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33495986461639404},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.33452874422073364},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20357266068458557},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.1918734908103943},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2015.7163830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334395","display_name":"Feinstein Institutes for Medical Research","ror":"https://ror.org/05dnene97"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W8870360","https://openalex.org/W1999694937","https://openalex.org/W2009103351","https://openalex.org/W2044266196","https://openalex.org/W2048207814","https://openalex.org/W2058415227","https://openalex.org/W2061627323","https://openalex.org/W2113952909","https://openalex.org/W2125109427","https://openalex.org/W4236706032","https://openalex.org/W6600367688"],"related_works":["https://openalex.org/W4235479087","https://openalex.org/W357196361","https://openalex.org/W2027314909","https://openalex.org/W1036938216","https://openalex.org/W3109425891","https://openalex.org/W2383820648","https://openalex.org/W2113714434","https://openalex.org/W3096637473","https://openalex.org/W2377792686","https://openalex.org/W4200439127"],"abstract_inverted_index":{"Atypical":[0],"parkinsonian":[1],"syndromes":[2],"are":[3,19],"often":[4,99],"difficult":[5],"to":[6,32,53,88,133,138],"diagnose":[7],"because":[8],"they":[9],"present":[10],"common":[11],"clinical":[12],"symptoms":[13],"and":[14,75],"differences":[15],"in":[16,28,85,107,118],"diagnostic":[17,96],"images":[18],"subtle.":[20],"Multivariate":[21],"covariance":[22],"analysis":[23],"has":[24],"been":[25,51],"previously":[26],"used":[27],"PET":[29],"group":[30],"data":[31,80],"identify":[33],"neurodegenerative":[34],"disease":[35,48,59,92,109],"patterns.":[36],"In":[37],"particular,":[38],"using":[39],"SSM-PCA":[40],"analysis,":[41],"individual":[42],"subject's":[43],"pattern":[44,73,104],"expression":[45],"of":[46,58,70,128],"characteristic":[47],"patterns":[49],"have":[50],"shown":[52],"correlate":[54],"with":[55],"independent":[56],"measures":[57],"status.":[60],"These":[61],"scalar":[62],"subject":[63,79,140],"scores,":[64],"evaluated":[65],"as":[66],"the":[67,71,76,125,134],"inner":[68,126],"product":[69,127],"unitized":[72],"vector":[74],"mean":[77],"centered":[78],"vector,":[81],"can":[82],"be":[83,121],"utilized":[84],"classification":[86,119],"algorithms":[87],"differentiate":[89],"patients":[90],"requiring":[91],"specific":[93],"treatment.":[94],"However,":[95],"accuracy":[97],"is":[98],"compromised":[100],"stemming":[101],"from":[102],"topographic":[103],"similarity":[105],"resulting":[106],"overlapping":[108],"score":[110],"expression.":[111],"Here,":[112],"we":[113],"show":[114],"that":[115],"some":[116],"improvement":[117],"may":[120],"achieved":[122],"by":[123],"utilizing":[124],"standardized":[129],"pattern/patient":[130],"vectors":[131],"equivalent":[132],"Pearson's":[135],"correlation":[136],"coefficient":[137],"evaluate":[139],"class":[141],"scores.":[142]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}