{"id":"https://openalex.org/W1995487368","doi":"https://doi.org/10.1109/isbi.2014.6868141","title":"Automated surface segmentation of internal limiting membrane in spectral-domain optical coherence tomography volumes with a deep cup using a 3-D range expansion approach","display_name":"Automated surface segmentation of internal limiting membrane in spectral-domain optical coherence tomography volumes with a deep cup using a 3-D range expansion approach","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1995487368","doi":"https://doi.org/10.1109/isbi.2014.6868141","mag":"1995487368"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2014.6868141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6868141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066834423","display_name":"Abhay Shah","orcid":"https://orcid.org/0000-0001-5005-7273"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Shah","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045926452","display_name":"Jui-Kai Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jui-Kai Wang","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032968409","display_name":"Mona K. Garvin","orcid":"https://orcid.org/0000-0003-3299-3150"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210132647","display_name":"Iowa City VA Health Care System","ror":"https://ror.org/04hgm3062","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona K. Garvin","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","Dept. of Veterans Affairs, VA Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Dept. of Veterans Affairs, VA Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I4210132647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836634","display_name":"Milan Sonka","orcid":"https://orcid.org/0000-0002-9613-9968"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milan Sonka","raw_affiliation_strings":["Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","Dept. of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Dept. of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101702310","display_name":"Xiaodong Wu","orcid":"https://orcid.org/0000-0002-8005-6738"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Wu","raw_affiliation_strings":["Dept. of Radiation and Oncology, University of Iowa, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Radiation and Oncology, University of Iowa, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4342,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81020734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"29","issue":null,"first_page":"1405","last_page":"1408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.831659197807312},{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.6540754437446594},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5936099290847778},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5785858631134033},{"id":"https://openalex.org/keywords/optic-nerve","display_name":"Optic nerve","score":0.5393808484077454},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5180121064186096},{"id":"https://openalex.org/keywords/optic-cup","display_name":"Optic cup (embryology)","score":0.4515376389026642},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.44890493154525757},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4036623537540436},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3606069087982178},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.26018548011779785},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1724953055381775},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17120808362960815},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.15171554684638977}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.831659197807312},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6540754437446594},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5936099290847778},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5785858631134033},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.5393808484077454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5180121064186096},{"id":"https://openalex.org/C96021297","wikidata":"https://www.wikidata.org/wiki/Q7098791","display_name":"Optic cup (embryology)","level":5,"score":0.4515376389026642},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.44890493154525757},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4036623537540436},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3606069087982178},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.26018548011779785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1724953055381775},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17120808362960815},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.15171554684638977},{"id":"https://openalex.org/C114696181","wikidata":"https://www.wikidata.org/wiki/Q5422650","display_name":"Eye development","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2014.6868141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6868141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1549946184","https://openalex.org/W2106255562","https://openalex.org/W2106809923","https://openalex.org/W2113137767","https://openalex.org/W2127318120","https://openalex.org/W2140502500","https://openalex.org/W2164774194","https://openalex.org/W4245839829","https://openalex.org/W4293101293","https://openalex.org/W6633064582"],"related_works":["https://openalex.org/W2500847435","https://openalex.org/W2914110926","https://openalex.org/W4225246715","https://openalex.org/W4296965207","https://openalex.org/W2802544014","https://openalex.org/W2534129789","https://openalex.org/W2947981745","https://openalex.org/W2337624925","https://openalex.org/W3132016183","https://openalex.org/W2588475615"],"abstract_inverted_index":{"Spectral-domain":[0],"optical":[1],"coherence":[2],"tomography":[3],"(SD-OCT)":[4],"is":[5,79],"used":[6,164],"clinically":[7],"for":[8,98,211],"the":[9,16,30,35,43,46,94,133,162,176,193],"diagnosis":[10],"and":[11,53,74,140,191,218],"management":[12],"of":[13,25,34,40,45,58,71,105,112],"glaucoma,":[14,42],"with":[15,107,148],"internal":[17],"limiting":[18],"membrane":[19],"(ILM)":[20],"being":[21],"one":[22,156],"important":[23],"structure":[24],"interest":[26],"as":[27],"it":[28],"reflects":[29],"upper":[31],"bounding":[32],"surface":[33,63,136,144,216],"optic":[36,47,119],"cup.":[37],"In":[38,82],"cases":[39,70],"severe":[41,108],"boundary":[44],"cup":[48,77],"can":[49],"become":[50],"very":[51],"steep":[52],"difficult":[54],"to":[55,150,161,185,202,214],"segment.":[56],"Because":[57],"this":[59,83,113],"difficulty,":[60],"current":[61],"automated":[62],"segmentation":[64,90,101,217],"algorithms":[65],"will":[66],"frequently":[67],"fail":[68],"in":[69,102,175,192],"deep":[72],"cupping":[73],"provide":[75],"a":[76,87,172],"that":[78],"too":[80],"shallow.":[81],"work,":[84],"we":[85],"propose":[86],"3-D":[88],"graph-theoretic":[89],"method":[91,170],"based":[92],"on":[93,117],"range":[95],"expansion":[96],"algorithm":[97],"accurate":[99],"ILM":[100],"SD-OCT":[103],"volumes":[104,125],"subjects":[106],"glaucoma.":[109],"The":[110],"performance":[111],"approach":[114],"was":[115,180,197],"validated":[116],"10":[118,128],"nerve":[120],"head":[121],"(ONH)":[122],"centered":[123],"OCT":[124],"obtained":[126],"from":[127,155,182,199],"glaucomatous":[129],"subjects.":[130],"We":[131],"computed":[132],"unsigned":[134,141],"mean":[135],"positioning":[137],"(UMSP)":[138],"error":[139,147,178,195],"average":[142],"symmetric":[143],"distance":[145],"(UASSD)":[146],"respect":[149],"manual":[151],"tracings":[152],"(ground":[153],"truth)":[154],"independent":[157],"expert":[158],"observer.":[159],"Comparing":[160],"widely":[163],"graph":[165],"search":[166],"method,":[167],"our":[168],"proposed":[169],"achieved":[171],"significant":[173],"improvement":[174],"UMSP":[177],"which":[179,196],"reduced":[181,198],"7.69\u00b13.23":[183],"\u03bcm":[184,187,201],"6.35\u00b11.35":[186],"(p":[188,204],"<;":[189,205],"0.04),":[190],"UASSD":[194],"3.86\u00b10.54":[200],"3.40\u00b10.17\u03bcm":[203],"0.07).":[206],"It":[207],"has":[208],"high":[209],"potential":[210],"future":[212],"extension":[213],"multiple":[215],"clinical":[219],"applicability.":[220]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}