{"id":"https://openalex.org/W2057793809","doi":"https://doi.org/10.1109/isbi.2014.6868030","title":"Improved resolution and reliability in dynamic PET using Bayesian regularization of MRTM2","display_name":"Improved resolution and reliability in dynamic PET using Bayesian regularization of MRTM2","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2057793809","doi":"https://doi.org/10.1109/isbi.2014.6868030","mag":"2057793809"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2014.6868030","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6868030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024945943","display_name":"Mikael Agn","orcid":"https://orcid.org/0000-0002-4266-023X"},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Mikael Agn","raw_affiliation_strings":["DTU Compute, Technical University of Denmark, Denmark","Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark"],"affiliations":[{"raw_affiliation_string":"DTU Compute, Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015994033","display_name":"Claus Svarer","orcid":"https://orcid.org/0000-0001-7811-1825"},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus Svarer","raw_affiliation_strings":["Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark"],"affiliations":[{"raw_affiliation_string":"Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029788021","display_name":"Vibe G. Fr\u00f8kj\u00e6r","orcid":"https://orcid.org/0000-0002-9321-2365"},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Vibe G. Frokjaer","raw_affiliation_strings":["Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark"],"affiliations":[{"raw_affiliation_string":"Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065328764","display_name":"Douglas N. Greve","orcid":"https://orcid.org/0000-0002-0610-0155"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas N. Greve","raw_affiliation_strings":["MGH, Harvard Medical School, USA"],"affiliations":[{"raw_affiliation_string":"MGH, Harvard Medical School, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015895924","display_name":"Gitte M. Knudsen","orcid":"https://orcid.org/0000-0003-1508-6866"},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Gitte M. Knudsen","raw_affiliation_strings":["Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark"],"affiliations":[{"raw_affiliation_string":"Neurobiology Research Unit and Cimbi, Copenhagen University Hospital, Rigshospitalet, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047520245","display_name":"Koen Van Leemput","orcid":"https://orcid.org/0000-0001-6466-5309"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["DK","FI","US"],"is_corresponding":false,"raw_author_name":"Koen Van Leemput","raw_affiliation_strings":["DTU Compute, Technical University of Denmark, Denmark","Departments of Information and Computer Science and of Biomedical Engineering and Computational Science, Aalto University, Finland","MGH, Harvard Medical School, USA"],"affiliations":[{"raw_affiliation_string":"DTU Compute, Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Departments of Information and Computer Science and of Biomedical Engineering and Computational Science, Aalto University, Finland","institution_ids":["https://openalex.org/I9927081"]},{"raw_affiliation_string":"MGH, Harvard Medical School, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024945943"],"corresponding_institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I96673099"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13894318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":null,"first_page":"955","last_page":"958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5844958424568176},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5842452049255371},{"id":"https://openalex.org/keywords/multilinear-map","display_name":"Multilinear map","score":0.568484365940094},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.48372653126716614},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.4820419251918793},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.47148558497428894},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.4661743640899658},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.4603343904018402},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44658780097961426},{"id":"https://openalex.org/keywords/gaussian-process","display_name":"Gaussian process","score":0.4215050935745239},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.40130603313446045},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3840321898460388},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3191528916358948}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5844958424568176},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5842452049255371},{"id":"https://openalex.org/C84392682","wikidata":"https://www.wikidata.org/wiki/Q1952404","display_name":"Multilinear map","level":2,"score":0.568484365940094},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.48372653126716614},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.4820419251918793},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.47148558497428894},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.4661743640899658},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.4603343904018402},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44658780097961426},{"id":"https://openalex.org/C61326573","wikidata":"https://www.wikidata.org/wiki/Q1496376","display_name":"Gaussian process","level":3,"score":0.4215050935745239},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.40130603313446045},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3840321898460388},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3191528916358948},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2014.6868030","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6868030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:publications/ec029c04-d0f4-44ed-b1d4-b07727caefa5","is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/ec029c04-d0f4-44ed-b1d4-b07727caefa5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Agn , M , Svarer , C , Frokjaer , V G , Greve , D N , Knudsen , G M &amp; Van Leemput , K 2014 , Improved resolution and reliability in dynamic PET using Bayesian regularization of MRTM2 . in Proceedings of the 11th IEEE International Symposium on Biomedical Imaging (ISBI 2014 ) . IEEE , pp. 955-658 , 2014 IEEE International Symposium on Biomedical Imaging , Beijing , China , 29/04/2014 . https://doi.org/10.1109/ISBI.2014.6868030","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2001452654","https://openalex.org/W2030773481","https://openalex.org/W2051036431","https://openalex.org/W2053923183","https://openalex.org/W2055879584","https://openalex.org/W2066297854","https://openalex.org/W2086448634","https://openalex.org/W2105355656","https://openalex.org/W2133257322","https://openalex.org/W2144035325","https://openalex.org/W2145587059","https://openalex.org/W2151227755","https://openalex.org/W2159912858","https://openalex.org/W2165269558","https://openalex.org/W4212863985","https://openalex.org/W4241074797","https://openalex.org/W6681609668"],"related_works":["https://openalex.org/W4318719034","https://openalex.org/W37958683","https://openalex.org/W1999178348","https://openalex.org/W2396820687","https://openalex.org/W4295021234","https://openalex.org/W3035010459","https://openalex.org/W4298178514","https://openalex.org/W4296311369","https://openalex.org/W3151212431","https://openalex.org/W2364569551"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"a":[3,13,69,93,101],"mathematical":[4],"model":[5,19,44,76],"that":[6,35,74],"regularizes":[7],"dynamic":[8],"PET":[9,58],"data":[10],"by":[11,68,111],"using":[12],"Bayesian":[14],"framework.":[15],"We":[16,72],"base":[17],"the":[18,21,33,48,53,75,84,89],"on":[20,32,106],"well":[22],"known":[23],"two-parameter":[24],"multilinear":[25],"reference":[26],"tissue":[27],"method":[28],"MRTM2":[29],"and":[30],"regularize":[31],"assumption":[34],"spatially":[36],"close":[37],"regions":[38],"have":[39],"similar":[40],"parameters.":[41],"The":[42],"developed":[43],"is":[45],"compared":[46],"to":[47],"conventional":[49,85],"approach":[50],"of":[51,57,63,80],"improving":[52],"low":[54],"signal-to-noise":[55],"ratio":[56],"data,":[59,109],"i.e.,":[60],"spatial":[61],"filtering":[62],"each":[64],"time":[65,91],"frame":[66],"independently":[67],"Gaussian":[70],"kernel.":[71],"show":[73],"handles":[77],"high":[78],"levels":[79],"noise":[81],"better":[82],"than":[83],"approach,":[86],"while":[87],"at":[88],"same":[90],"retaining":[92],"higher":[94,102],"resolution.":[95],"In":[96],"addition,":[97],"it":[98],"results":[99],"in":[100],"reliability":[103],"between":[104],"scans":[105],"individual":[107],"subject":[108],"measured":[110],"intraclass":[112],"correlation":[113],"for":[114],"absolute":[115],"agreement.":[116]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
