{"id":"https://openalex.org/W2093179270","doi":"https://doi.org/10.1109/isbi.2014.6867958","title":"Joint identification of imaging and proteomics biomarkers of Alzheimer's disease using network-guided sparse learning","display_name":"Joint identification of imaging and proteomics biomarkers of Alzheimer's disease using network-guided sparse learning","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2093179270","doi":"https://doi.org/10.1109/isbi.2014.6867958","mag":"2093179270","pmid":"https://pubmed.ncbi.nlm.nih.gov/25408822"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2014.6867958","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6867958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4232946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103218500","display_name":"Jingwen Yan","orcid":"https://orcid.org/0000-0001-9066-4908"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jingwen Yan","raw_affiliation_strings":["Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA"],"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060016795","display_name":"Heng Huang","orcid":"https://orcid.org/0000-0002-3483-8333"},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Huang","raw_affiliation_strings":["Computer Science and Engineering, University of Texas at Arlington, TX, USA"],"affiliations":[{"raw_affiliation_string":"Computer Science and Engineering, University of Texas at Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709686","display_name":"Sungeun Kim","orcid":"https://orcid.org/0000-0002-7558-8502"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sungeun Kim","raw_affiliation_strings":["Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA"],"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Moore","raw_affiliation_strings":["Genetics, Community and Family Medicine, School of Medicine at Dartmouth College, NH, USA"],"affiliations":[{"raw_affiliation_string":"Genetics, Community and Family Medicine, School of Medicine at Dartmouth College, NH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Saykin","raw_affiliation_strings":["Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA"],"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA"],"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, BioHealth Informatics, Indiana University, IN, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103218500"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4134,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64408254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"665","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modalities","display_name":"Modalities","score":0.6907274127006531},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6827583909034729},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6477261781692505},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5812281370162964},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5635493993759155},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5432357788085938},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5172034502029419},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.49493497610092163},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.4582291543483734},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.44304946064949036},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4427736699581146},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4401649236679077},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.4211505055427551},{"id":"https://openalex.org/keywords/dictionary-learning","display_name":"Dictionary learning","score":0.4183049201965332},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19804129004478455},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1592947542667389},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.14004549384117126},{"id":"https://openalex.org/keywords/sparse-approximation","display_name":"Sparse approximation","score":0.12016710638999939},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09872272610664368}],"concepts":[{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.6907274127006531},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6827583909034729},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6477261781692505},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5812281370162964},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5635493993759155},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5432357788085938},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5172034502029419},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.49493497610092163},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4582291543483734},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44304946064949036},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4427736699581146},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4401649236679077},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4211505055427551},{"id":"https://openalex.org/C2988886741","wikidata":"https://www.wikidata.org/wiki/Q25304494","display_name":"Dictionary learning","level":3,"score":0.4183049201965332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19804129004478455},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1592947542667389},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14004549384117126},{"id":"https://openalex.org/C124066611","wikidata":"https://www.wikidata.org/wiki/Q28684319","display_name":"Sparse approximation","level":2,"score":0.12016710638999939},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09872272610664368},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2014.6867958","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2014.6867958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:25408822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25408822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4232946","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4232946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4232946","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4232946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W50186089","https://openalex.org/W1977015023","https://openalex.org/W2007044705","https://openalex.org/W2010176747","https://openalex.org/W2023513683","https://openalex.org/W2102241087","https://openalex.org/W2131215891","https://openalex.org/W2154865814","https://openalex.org/W2157412686","https://openalex.org/W4249565903"],"related_works":["https://openalex.org/W2185469136","https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W2031369865","https://openalex.org/W1969295409","https://openalex.org/W2010715465","https://openalex.org/W2558197048","https://openalex.org/W3150792906","https://openalex.org/W1999883774","https://openalex.org/W2062711653"],"abstract_inverted_index":{"Identification":[0],"of":[1,6,31],"biomarkers":[2,100],"for":[3,29],"early":[4],"detection":[5],"Alzheimer's":[7],"disease":[8],"(AD)":[9],"is":[10],"an":[11],"important":[12],"research":[13],"topic.":[14],"Prior":[15],"work":[16],"has":[17],"shown":[18],"that":[19,86],"multimodal":[20,99],"imaging":[21,80],"and":[22,67,81,84],"biomarker":[23],"data":[24,41],"could":[25],"provide":[26],"complementary":[27,65],"information":[28,66],"prediction":[30],"cognitive":[32,77],"or":[33,46],"AD":[34],"status.":[35],"However,":[36],"the":[37,64,87],"relationship":[38],"among":[39],"multiple":[40],"modalities":[42],"are":[43],"often":[44],"ignored":[45],"oversimplified":[47],"in":[48],"prior":[49],"studies.":[50],"To":[51],"address":[52],"this":[53,73],"issue,":[54],"we":[55],"propose":[56],"a":[57],"network-guided":[58],"sparse":[59],"learning":[60],"model":[61,74,89],"to":[62,75],"embrace":[63],"inter-relationships":[68],"between":[69],"modalities.":[70],"We":[71],"apply":[72],"predict":[76],"outcome":[78],"from":[79],"proteomic":[82],"data,":[83],"show":[85],"proposed":[88],"not":[90],"only":[91],"outperforms":[92],"traditional":[93],"ones,":[94],"but":[95],"also":[96],"yields":[97],"stable":[98],"across":[101],"cross-validation":[102],"trials.":[103]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
