{"id":"https://openalex.org/W2059229129","doi":"https://doi.org/10.1109/isbi.2013.6556815","title":"A 3D intensity model based on spherical harmonics for automatic 3D segmentation of heterochromatin foci","display_name":"A 3D intensity model based on spherical harmonics for automatic 3D segmentation of heterochromatin foci","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2059229129","doi":"https://doi.org/10.1109/isbi.2013.6556815","mag":"2059229129"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2013.6556815","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2013.6556815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE 10th International Symposium on Biomedical Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072924172","display_name":"Simon Eck","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Simon Eck","raw_affiliation_strings":["BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065703260","display_name":"Karl Rohr","orcid":"https://orcid.org/0000-0001-7673-0999"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Rohr","raw_affiliation_strings":["BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085772120","display_name":"Andreas Biesdorf","orcid":"https://orcid.org/0000-0003-0206-7746"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Biesdorf","raw_affiliation_strings":["BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078701330","display_name":"Katharina M\u00fcller\u2010Ott","orcid":"https://orcid.org/0000-0002-1918-1046"},"institutions":[{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Muller-Ott","raw_affiliation_strings":["BIOQUANT, Research Group Genome Organization & Function, DKFZ Heidelberg, Germany","Res. Group Genome Organ. & Function, DKFZ Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, Research Group Genome Organization & Function, DKFZ Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Res. Group Genome Organ. & Function, DKFZ Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063410783","display_name":"Karsten Rippe","orcid":"https://orcid.org/0000-0001-9951-9395"},"institutions":[{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karsten Rippe","raw_affiliation_strings":["BIOQUANT, Research Group Genome Organization & Function, DKFZ Heidelberg, Germany","Res. Group Genome Organ. & Function, DKFZ Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, Research Group Genome Organization & Function, DKFZ Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Res. Group Genome Organ. & Function, DKFZ Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038055772","display_name":"Stefan W\u00f6rz","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Worz","raw_affiliation_strings":["BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"BIOQUANT, IPMB, and DKFZ Heidelberg, Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Dept. Bioinf. & Functional Genomics, Univ. of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072924172"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":1.2217,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.85663667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"1484","last_page":"1487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spherical-harmonics","display_name":"Spherical harmonics","score":0.8398312330245972},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6251598596572876},{"id":"https://openalex.org/keywords/harmonics","display_name":"Harmonics","score":0.5517041683197021},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5487688779830933},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5351764559745789},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5125798583030701},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5096240043640137},{"id":"https://openalex.org/keywords/parametric-model","display_name":"Parametric model","score":0.49700334668159485},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4908807873725891},{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.4903435707092285},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4809231460094452},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3585798144340515},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34093934297561646},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25563085079193115},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24345514178276062},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.10001766681671143}],"concepts":[{"id":"https://openalex.org/C3768446","wikidata":"https://www.wikidata.org/wiki/Q877100","display_name":"Spherical harmonics","level":2,"score":0.8398312330245972},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6251598596572876},{"id":"https://openalex.org/C188414643","wikidata":"https://www.wikidata.org/wiki/Q3001183","display_name":"Harmonics","level":3,"score":0.5517041683197021},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5487688779830933},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5351764559745789},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5125798583030701},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5096240043640137},{"id":"https://openalex.org/C24574437","wikidata":"https://www.wikidata.org/wiki/Q7135228","display_name":"Parametric model","level":3,"score":0.49700334668159485},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4908807873725891},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.4903435707092285},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4809231460094452},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3585798144340515},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34093934297561646},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25563085079193115},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24345514178276062},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.10001766681671143},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2013.6556815","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2013.6556815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE 10th International Symposium on Biomedical Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W40956716","https://openalex.org/W70082368","https://openalex.org/W1554639917","https://openalex.org/W1680579736","https://openalex.org/W2013772178","https://openalex.org/W2044197339","https://openalex.org/W2046385387","https://openalex.org/W2119463449","https://openalex.org/W2122751628","https://openalex.org/W2124701550","https://openalex.org/W2129465369","https://openalex.org/W2130771648","https://openalex.org/W2176412050","https://openalex.org/W3024018030","https://openalex.org/W3025492942","https://openalex.org/W3142915818","https://openalex.org/W3216003845","https://openalex.org/W6601664907"],"related_works":["https://openalex.org/W2370517014","https://openalex.org/W2039242888","https://openalex.org/W2515867587","https://openalex.org/W1838021708","https://openalex.org/W2379042074","https://openalex.org/W2535445299","https://openalex.org/W2020985248","https://openalex.org/W75722962","https://openalex.org/W2362354458","https://openalex.org/W4214595193"],"abstract_inverted_index":{"We":[0],"introduce":[1],"a":[2,20,28,45],"3D":[3,10,22,57,79],"model-based":[4],"approach":[5,18,72],"for":[6],"automatic":[7],"segmentation":[8],"of":[9,37],"fluorescent":[11],"heterochromatin":[12],"foci":[13,36],"from":[14],"microscopy":[15,80],"images.":[16],"The":[17,71],"employs":[19],"new":[21,50],"parametric":[23],"intensity":[24],"model":[25,51,62],"based":[26],"on":[27],"spherical":[29],"harmonics":[30],"(SH)":[31],"expansion":[32,67],"and":[33,39,60,83],"can":[34],"represent":[35],"regular":[38],"highly":[40],"irregular":[41],"shapes.":[42],"By":[43],"solving":[44],"least-squares":[46],"minimization":[47],"problem,":[48],"the":[49,56,61,65],"is":[52],"directly":[53],"fitted":[54],"to":[55,77,87],"image":[58,81],"data,":[59],"parameters":[63],"including":[64],"SH":[66],"coefficients":[68],"are":[69],"estimated.":[70],"has":[73,84],"been":[74,85],"successfully":[75],"applied":[76],"real":[78],"data":[82],"compared":[86],"previous":[88],"approaches.":[89]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}