{"id":"https://openalex.org/W2061978615","doi":"https://doi.org/10.1109/isbi.2013.6556497","title":"Cube propagation for focal brain atrophy estimation","display_name":"Cube propagation for focal brain atrophy estimation","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2061978615","doi":"https://doi.org/10.1109/isbi.2013.6556497","mag":"2061978615"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2013.6556497","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2013.6556497","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE 10th International Symposium on Biomedical Imaging","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102676931","display_name":"Akshay Pai","orcid":"https://orcid.org/0000-0002-0087-1629"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Akshay Pai","raw_affiliation_strings":["DIKU, University of Copenhagen, Denmark","DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051106845","display_name":"Joyce Suhy","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce Suhy","raw_affiliation_strings":["Synarc, Inc., Newark, CA, USA","Synarc Inc., Newark, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synarc, Inc., Newark, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Synarc Inc., Newark, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006195104","display_name":"Jon Sporring","orcid":"https://orcid.org/0000-0003-1261-6702"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jon Sporring","raw_affiliation_strings":["DIKU, University of Copenhagen, Denmark","DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055800699","display_name":"Mads Nielsen","orcid":"https://orcid.org/0000-0003-1535-068X"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mads Nielsen","raw_affiliation_strings":["DIKU, University of Copenhagen, Denmark","DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047828457","display_name":"Lauge S\u00f8rensen","orcid":"https://orcid.org/0000-0002-1181-7150"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lauge Sorensen","raw_affiliation_strings":["DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087093410","display_name":"Sune Darkner","orcid":"https://orcid.org/0000-0001-6114-7100"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sune Darkner","raw_affiliation_strings":["DIKU, University of Copenhagen, Denmark","DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004155897","display_name":"Peter Mysling","orcid":null},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Mysling","raw_affiliation_strings":["DIKU, University of Copenhagen, Denmark","DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045929408","display_name":"Dan Richter J\u00f8rgensen","orcid":"https://orcid.org/0000-0003-3801-4523"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Dan Jorgensen","raw_affiliation_strings":["DIKU University of Copenhagen, Copenhagen, Denmark#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIKU University of Copenhagen, Copenhagen, Denmark#TAB#","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008183217","display_name":"Erik B. Dam","orcid":"https://orcid.org/0000-0002-8888-2524"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik B Dam","raw_affiliation_strings":["Biomediq A/S, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomediq A/S, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022946341","display_name":"Martin Lillholm","orcid":"https://orcid.org/0000-0002-1402-6899"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Lillholm","raw_affiliation_strings":["Biomediq A/S, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomediq A/S, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109256331","display_name":"Joonmi Oh","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joonmi Oh","raw_affiliation_strings":["Synarc, Inc., Newark, CA, USA","Synarc Inc., Newark, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synarc, Inc., Newark, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Synarc Inc., Newark, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022178825","display_name":"Gennan Chen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gennan Chen","raw_affiliation_strings":["Synarc, Inc., Newark, CA, USA","Synarc Inc., Newark, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synarc, Inc., Newark, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Synarc Inc., Newark, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":null,"first_page":"402","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cube","display_name":"Cube (algebra)","score":0.7135990858078003},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.5513078570365906},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.523496687412262},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4338655173778534},{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.4256255328655243},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2100110650062561},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2070474922657013},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12287122011184692},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0857485830783844},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.06586837768554688}],"concepts":[{"id":"https://openalex.org/C53051483","wikidata":"https://www.wikidata.org/wiki/Q861555","display_name":"Cube (algebra)","level":2,"score":0.7135990858078003},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5513078570365906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.523496687412262},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4338655173778534},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4256255328655243},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2100110650062561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2070474922657013},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12287122011184692},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0857485830783844},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.06586837768554688},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2013.6556497","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2013.6556497","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE 10th International Symposium on Biomedical Imaging","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/dafa33db-b617-4a5e-9c0f-bea73a9f2bd2","is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/dafa33db-b617-4a5e-9c0f-bea73a9f2bd2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pai , A S U , S\u00f8rensen , L , Darkner , S , Mysling , P , J\u00f8rgensen , D R , Dam , E B , Lillholm , M , Oh , J , Chen , G , Suhy , J , Sporring , J & Nielsen , M 2013 , Cube propagation for focal brain atrophy estimation . in 2013 IEEE 10th International Symposium on Biomedical Imaging . IEEE , pp. 402-405 , International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 , San Francisco, CA , United States , 07/04/2013 . https://doi.org/10.1109/ISBI.2013.6556497","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1973989244","https://openalex.org/W2004727110","https://openalex.org/W2014710124","https://openalex.org/W2025152196","https://openalex.org/W2051434435","https://openalex.org/W2056898461","https://openalex.org/W2092729012","https://openalex.org/W2093092963","https://openalex.org/W2103481737","https://openalex.org/W2113576511","https://openalex.org/W2119000771","https://openalex.org/W2149128281","https://openalex.org/W6643854598"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4405810791","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4283690284","https://openalex.org/W4396701345","https://openalex.org/W2376932109"],"abstract_inverted_index":{"Precise":[0],"and":[1,6,29,77,93,103,112,126,141,169,177],"robust":[2],"whole":[3,107],"brain,":[4],"ventricle,":[5],"hippocampal":[7],"atrophy":[8,85,92,109],"measurements":[9],"are":[10,21,40],"important":[11],"as":[12,15,23,162,167,174],"they":[13,30],"serve":[14],"biomarkers":[16],"for":[17,87],"Alzheimer's":[18],"disease.":[19],"They":[20],"used":[22,188],"secondary":[24],"outcomes":[25],"in":[26,48],"drug":[27],"trials,":[28],"correlate":[31],"with":[32],"the":[33,45,80,142,145,154,165,175,185,186],"cognitive":[34],"scores.":[35],"When":[36],"two":[37],"successive":[38],"scans":[39],"non-linearly":[41],"aligned":[42],"by":[43,57,130],"registration,":[44],"volume":[46],"change":[47],"a":[49,83,116,124,127,131,137],"region":[50],"of":[51,82,91,100,118,147],"interest":[52],"(ROI)":[53],"is":[54],"typically":[55],"computed":[56],"Jacobian":[58],"integration":[59],"(JI),":[60],"volumetric":[61],"meshing":[62],"(VM),":[63],"or":[64,72,89],"surface":[65,69,73],"based":[66],"methods":[67],"like":[68],"triangulation":[70],"(ST)":[71],"flux":[74],"(SF).":[75],"JI":[76,111,168],"VM":[78,134],"offer":[79,106],"possibility":[81],"voxel-by-voxel":[84],"measure":[86,99],"visualization":[88],"localization":[90,166],"subsequent":[94],"summing":[95],"to":[96,184],"an":[97],"ROI":[98,108],"atrophy.":[101],"ST":[102,143,176],"SF":[104,113],"only":[105],"measures.":[110],"suffer":[114],"from":[115,121,136,144],"lack":[117,146],"precision":[119,161,183],"originating":[120],"respectively":[122],"approximating":[123],"space":[125],"time":[128],"integral":[129],"finite":[132],"sum.":[133],"suffers":[135],"high":[138],"computational":[139,172],"burden":[140],"localization.":[148],"In":[149],"this":[150],"paper":[151],"we":[152],"present":[153],"cube":[155],"propagation":[156],"(CP)":[157],"algorithm":[158],"having":[159],"numerical":[160,182],"VM,":[163,170],"offering":[164],"but":[171],"simplicity":[173],"SF.":[178],"We":[179],"demonstrate":[180],"superior":[181],"commonly":[187],"JI.":[189]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}