{"id":"https://openalex.org/W2092395555","doi":"https://doi.org/10.1109/isbi.2012.6235846","title":"Automatic quantification of Tree-in-Bud patterns from CT scans","display_name":"Automatic quantification of Tree-in-Bud patterns from CT scans","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2092395555","doi":"https://doi.org/10.1109/isbi.2012.6235846","mag":"2092395555","pmid":"https://pubmed.ncbi.nlm.nih.gov/24443680"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2012.6235846","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3892705","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030188696","display_name":"Ula\u015f Ba\u011fc\u0131","orcid":"https://orcid.org/0000-0001-7379-6829"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ulas Bagci","raw_affiliation_strings":["Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","Center for Infectious Diseases Imaging, National Institutes of Health (NIH)"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]},{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH)","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028453521","display_name":"Kirsten Miller-Jaster","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten Miller-Jaster","raw_affiliation_strings":["Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","Center for Infectious Diseases Imaging, National Institutes of Health (NIH)"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]},{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH)","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695406","display_name":"Jianhua Yao","orcid":"https://orcid.org/0000-0001-9157-9596"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhua Yao","raw_affiliation_strings":["Department of Radiology and Imaging Sciences (NIH)"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004320483","display_name":"Albert W. Wu","orcid":"https://orcid.org/0000-0001-6189-7120"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Wu","raw_affiliation_strings":["Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","Center for Infectious Diseases Imaging, National Institutes of Health (NIH)"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]},{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH)","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101046136","display_name":"Jesus J. Caban","orcid":null},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Caban","raw_affiliation_strings":["Naval Medical Center, NICoE"],"affiliations":[{"raw_affiliation_string":"Naval Medical Center, NICoE","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113147167","display_name":"Kenneth N. Olivier","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161001","display_name":"Infectious Diseases and the Research Institute","ror":"https://ror.org/05x0bqw91","country_code":"US","type":"other","lineage":["https://openalex.org/I4210161001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth. N. Olivier","raw_affiliation_strings":["Laboratory of Clinical Infectious Diseases (NIH)"],"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Infectious Diseases (NIH)","institution_ids":["https://openalex.org/I4210161001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011834144","display_name":"\u00d6mer Aras","orcid":"https://orcid.org/0000-0003-1758-0542"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omer Aras","raw_affiliation_strings":["Department of Radiology and Imaging Sciences (NIH) ; National Cancer Institute (NIH)","Department of Radiology and Imaging Sciences (NIH)"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences (NIH) ; National Cancer Institute (NIH)","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074275355","display_name":"Daniel J. Mollura","orcid":"https://orcid.org/0000-0002-4754-9581"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Mollura","raw_affiliation_strings":["Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","Center for Infectious Diseases Imaging, National Institutes of Health (NIH)"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH) ; Department of Radiology and Imaging Sciences (NIH)","institution_ids":[]},{"raw_affiliation_string":"Center for Infectious Diseases Imaging, National Institutes of Health (NIH)","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5030188696"],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":0.2012,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59868197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"56","issue":null,"first_page":"1459","last_page":"1462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9611999988555908,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.925599992275238,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cad","display_name":"CAD","score":0.7101393342018127},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5880556106567383},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4383925795555115},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39852073788642883},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3597032129764557},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3176116347312927},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2433822751045227},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20501023530960083},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.09277704358100891}],"concepts":[{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.7101393342018127},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5880556106567383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4383925795555115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39852073788642883},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3597032129764557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3176116347312927},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2433822751045227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20501023530960083},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.09277704358100891},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi.2012.6235846","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:24443680","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24443680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:2878451","is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3892705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3892705","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3892705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3892705","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3892705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.699999988079071,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1601740268","https://openalex.org/W1665426383","https://openalex.org/W1989150662","https://openalex.org/W2006265748","https://openalex.org/W2044140763","https://openalex.org/W2044465660","https://openalex.org/W2068934234","https://openalex.org/W2089517195","https://openalex.org/W2099583331","https://openalex.org/W2110290656","https://openalex.org/W2167803594","https://openalex.org/W2319352096","https://openalex.org/W6637145877"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"In":[0,42],"this":[1],"paper,":[2],"we":[3],"present":[4],"a":[5,35,62,94,130],"fully":[6],"automatic":[7],"method":[8,21,90],"to":[9,28,44,74,119,166],"quantify":[10],"Tree-in-Bud":[11],"(TIB)":[12],"patterns":[13,33],"for":[14,54,170,194],"respiratory":[15],"tract":[16],"infections.":[17],"The":[18],"proposed":[19,88,160],"quantification":[20,69,89,161],"is":[22,52,91,163],"based":[23,92],"on":[24,48,93],"our":[25],"previous":[26],"effort":[27],"detect":[29],"and":[30,80,110,151,187,196],"track":[31],"TIB":[32,47,51,79,100,172],"with":[34,129],"computer":[36],"assisted":[37],"detection":[38],"(CAD)":[39],"system":[40,106,162,169],"[9].":[41],"addition":[43],"accurately":[45],"identifying":[46],"CT,":[49],"quantifying":[50],"important":[53],"measuring":[55],"the":[56,75,104,114,127,159,167],"volume":[57,111],"of":[58,65,78,113,122,133,175],"affected":[59],"lung":[60],"as":[61,180],"potantial":[63],"marker":[64],"disease":[66],"severity.":[67],"This":[68],"can":[70],"be":[71],"challenging":[72],"due":[73],"complex":[76],"shape":[77],"high":[81],"intensity":[82],"variation":[83],"contributing":[84],"mixed":[85],"features.":[86],"Our":[87],"local":[95],"scale":[96],"concept":[97],"such":[98],"that":[99,158],"regions":[101,116],"detected":[102],"via":[103],"CAD":[105,168],"are":[107,117,178],"quantified":[108,115],"adaptively,":[109],"percentages":[112],"compared":[118],"visual":[120],"scoring":[121],"participating":[123],"radiologists.":[124],"We":[125],"conducted":[126],"experiments":[128],"data":[131],"set":[132],"94":[134],"chest":[135],"CTs":[136],"(laboratory":[137],"confirmed":[138],"39":[139],"viral":[140],"bronchiolitis":[141],"caused":[142],"by":[143],"human":[144],"parainfluenza":[145],"(HPIV),":[146],"34":[147],"nontuberculous":[148],"mycobacterial":[149],"(NTM),":[150],"21":[152],"normal":[153],"control).":[154],"Experimental":[155],"results":[156],"show":[157],"well":[164],"suited":[165],"detecting":[171],"patterns.":[173],"Correlations":[174],"observer-CAD":[176],"agreements":[177],"reported":[179],"(<i>R</i><sup>2</sup>":[181,188],"=":[182,189],"0.824,":[183],"<i>p</i>":[184,191],"<":[185,192],"0.01)":[186,193],"0.801,":[190],"HPIV":[195],"NTM":[197],"cases,":[198],"respectively.":[199]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}