{"id":"https://openalex.org/W1975357038","doi":"https://doi.org/10.1109/isbi.2012.6235587","title":"Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions","display_name":"Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W1975357038","doi":"https://doi.org/10.1109/isbi.2012.6235587","mag":"1975357038","pmid":"https://pubmed.ncbi.nlm.nih.gov/23743800"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2012.6235587","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235587","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113631335","display_name":"Carlos S. Mendoza","orcid":null},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. S. Mendoza","raw_affiliation_strings":["Universidad de Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064775862","display_name":"George R. Washko","orcid":"https://orcid.org/0000-0002-2712-0569"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. R. Washko","raw_affiliation_strings":["Harvard Medical School, Brigham and Women's Hospital, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062538082","display_name":"James C. Ross","orcid":"https://orcid.org/0000-0002-2338-3644"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Ross","raw_affiliation_strings":["Harvard Medical School, Brigham and Women's Hospital, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026585250","display_name":"Alejandro A. D\u00edaz","orcid":"https://orcid.org/0000-0001-5037-2919"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"A. A. Diaz","raw_affiliation_strings":["Harvard Medical School, Brigham and Women's Hospital, USA","Pontificia Universidad Cat\u00f3lica de Chile, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Pontificia Universidad Cat\u00f3lica de Chile, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023897162","display_name":"David A. Lynch","orcid":"https://orcid.org/0000-0002-6329-2325"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Lynch","raw_affiliation_strings":["National Jewish Medical and Research Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Medical and Research Center, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110859173","display_name":"J. D. Crapo","orcid":null},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Crapo","raw_affiliation_strings":["National Jewish Medical and Research Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Medical and Research Center, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. K. Silverman","raw_affiliation_strings":["Harvard Medical School, Brigham and Women's Hospital, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004205811","display_name":"Bego\u00f1a Acha","orcid":"https://orcid.org/0000-0001-7838-5746"},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B. Acha","raw_affiliation_strings":["Universidad de Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013653280","display_name":"Carmen Serrano","orcid":"https://orcid.org/0000-0003-3008-6231"},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Serrano","raw_affiliation_strings":["Universidad de Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002685368","display_name":"Ra\u00fal San Jo\u015be Est\u00e9par","orcid":"https://orcid.org/0000-0002-3677-1996"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. San Jose Estepar","raw_affiliation_strings":["Harvard Medical School, Brigham and Women's Hospital, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.1836,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9985687,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"474","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9621000289916992,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.953499972820282,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histogram","display_name":"Histogram","score":0.7993608117103577},{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.7212487459182739},{"id":"https://openalex.org/keywords/scanner","display_name":"Scanner","score":0.6244784593582153},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.5924195051193237},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.549945592880249},{"id":"https://openalex.org/keywords/pulmonary-disease","display_name":"Pulmonary disease","score":0.5491528511047363},{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.5051057934761047},{"id":"https://openalex.org/keywords/kernel-density-estimation","display_name":"Kernel density estimation","score":0.4914814233779907},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4563066065311432},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4303953945636749},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3175203204154968},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.25073015689849854},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23628833889961243},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07320219278335571},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.07210919260978699},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.06675830483436584}],"concepts":[{"id":"https://openalex.org/C53533937","wikidata":"https://www.wikidata.org/wiki/Q185020","display_name":"Histogram","level":3,"score":0.7993608117103577},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.7212487459182739},{"id":"https://openalex.org/C2779751349","wikidata":"https://www.wikidata.org/wiki/Q1474480","display_name":"Scanner","level":2,"score":0.6244784593582153},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.5924195051193237},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.549945592880249},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.5491528511047363},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5051057934761047},{"id":"https://openalex.org/C71134354","wikidata":"https://www.wikidata.org/wiki/Q458825","display_name":"Kernel density estimation","level":3,"score":0.4914814233779907},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4563066065311432},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4303953945636749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3175203204154968},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.25073015689849854},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23628833889961243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07320219278335571},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.07210919260978699},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06675830483436584},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2012.6235587","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235587","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:23743800","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23743800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:2669423","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3670097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2644038179","display_name":null,"funder_award_id":"U01 HL089897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3074978538","display_name":null,"funder_award_id":"K23 HL089353","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5861375725","display_name":null,"funder_award_id":"U01 HL089856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5967600711","display_name":null,"funder_award_id":"K25 HL104085","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1602966110","https://openalex.org/W1970378963","https://openalex.org/W2015853228","https://openalex.org/W2022564917","https://openalex.org/W2039051707","https://openalex.org/W2059432853","https://openalex.org/W2136361778","https://openalex.org/W2143708007","https://openalex.org/W2153464267","https://openalex.org/W2155662634","https://openalex.org/W2162983381","https://openalex.org/W2169487898","https://openalex.org/W2169907669","https://openalex.org/W3104298728"],"related_works":["https://openalex.org/W2326585857","https://openalex.org/W142525846","https://openalex.org/W2312602415","https://openalex.org/W2312864656","https://openalex.org/W2472126364","https://openalex.org/W2320098543","https://openalex.org/W2585009645","https://openalex.org/W2333131755","https://openalex.org/W4401482945","https://openalex.org/W2372297656"],"abstract_inverted_index":{"This":[0],"article":[1],"investigates":[2],"the":[3,51,88],"suitability":[4],"of":[5,30,54,63,90],"local":[6,55],"intensity":[7,56,92],"distributions":[8],"to":[9,48],"analyze":[10],"six":[11],"emphysema":[12],"classes":[13],"in":[14,34,95],"342":[15],"CT":[16],"scans":[17],"obtained":[18,58],"from":[19,59],"16":[20],"sites":[21],"hosting":[22],"scanners":[23],"by":[24,69],"3":[25],"vendors":[26],"and":[27,73],"a":[28,100],"total":[29],"9":[31],"specific":[32],"models":[33],"subjects":[35],"with":[36,50,80],"Chronic":[37],"Obstructive":[38],"Pulmonary":[39],"Disease":[40],"(COPD).":[41],"We":[42,65,76,86],"propose":[43],"using":[44,91],"kernel":[45],"density":[46],"estimation":[47],"deal":[49],"inherent":[52],"sparsity":[53],"histograms":[57],"scarcely":[60],"populated":[61],"regions":[62],"interest.":[64],"validate":[66],"our":[67,78],"approach":[68],"leave-one-subject-out":[70],"classification":[71],"experiments":[72],"full-lung":[74],"analyses.":[75],"compare":[77],"results":[79],"recently":[81],"published":[82],"LBP":[83],"texture-based":[84],"methodology.":[85],"demonstrate":[87],"efficacy":[89],"information":[93],"alone":[94],"multi-scanner":[96],"cohorts,":[97],"which":[98],"is":[99],"simpler,":[101],"more":[102],"intuitive":[103],"approach.":[104]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}