{"id":"https://openalex.org/W2033387958","doi":"https://doi.org/10.1109/isbi.2012.6235530","title":"Supervised in-vivo plaque characterization incorporating class label uncertainty","display_name":"Supervised in-vivo plaque characterization incorporating class label uncertainty","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2033387958","doi":"https://doi.org/10.1109/isbi.2012.6235530","mag":"2033387958"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2012.6235530","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235530","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051350171","display_name":"Arna van Engelen","orcid":"https://orcid.org/0000-0003-4145-0406"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Arna van Engelen","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038384386","display_name":"Wiro J. Niessen","orcid":"https://orcid.org/0000-0002-5822-1995"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wiro J Niessen","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052901925","display_name":"Stefan Klein","orcid":"https://orcid.org/0000-0003-4449-6784"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stefan Klein","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023339336","display_name":"Harald C. Groen","orcid":"https://orcid.org/0000-0003-3587-566X"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Harald C Groen","raw_affiliation_strings":["Depts. of Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Depts. of Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004726448","display_name":"Hence J.M. Verhagen","orcid":"https://orcid.org/0000-0002-0589-8329"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hence J M Verhagen","raw_affiliation_strings":["Depts. of Vascular Surgery, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Depts. of Vascular Surgery, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045033034","display_name":"Jolanda J. Wentzel","orcid":"https://orcid.org/0000-0001-9893-3404"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jolanda J Wentzel","raw_affiliation_strings":["Depts. of Vascular Surgery, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Depts. of Vascular Surgery, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006225939","display_name":"Aad van der Lugt","orcid":"https://orcid.org/0000-0002-6159-2228"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aad van der Lugt","raw_affiliation_strings":["Depts. of Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Depts. of Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023677285","display_name":"Marleen de Bruijne","orcid":"https://orcid.org/0000-0002-6328-902X"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marleen de Bruijne","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Depts. of Medical Informatics &amp; Radiology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5051350171"],"corresponding_institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":1.1137,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79693364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.7680846452713013},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6440012454986572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5990350842475891},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5345707535743713},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5280072689056396},{"id":"https://openalex.org/keywords/calcification","display_name":"Calcification","score":0.48087790608406067},{"id":"https://openalex.org/keywords/fibrous-cap","display_name":"Fibrous cap","score":0.4447675347328186},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.43955376744270325},{"id":"https://openalex.org/keywords/training-set","display_name":"Training set","score":0.4194185137748718},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.33963102102279663},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.23579031229019165},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1941688060760498},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12252643704414368}],"concepts":[{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.7680846452713013},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6440012454986572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5990350842475891},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5345707535743713},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5280072689056396},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.48087790608406067},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.4447675347328186},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43955376744270325},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.4194185137748718},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33963102102279663},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23579031229019165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1941688060760498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12252643704414368},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2012.6235530","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2012.6235530","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/595d95e5-0a27-419a-99d8-1f58273f2f02","is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/595d95e5-0a27-419a-99d8-1f58273f2f02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings, 246 - 249","raw_type":"info:eu-repo/semantics/conferencepaper"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/cede5f5b-1145-4959-a80b-17587f61b51c","is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/cede5f5b-1145-4959-a80b-17587f61b51c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Engelen , A V , Niessen , W J , Klein , S , Groen , H C , Verhagen , H J M , Wentzel , J J , van der Lugt , A & de Bruijne , M 2012 , Supervised in-vivo plaque characterization incorporating class label uncertainty . in 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI) . IEEE , pp. 246-249 , 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro , Barcelona , Spain , 02/05/2012 . https://doi.org/10.1109/ISBI.2012.6235530","raw_type":"contributionToPeriodical"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323596","display_name":"Center for Translational Molecular Medicine","ror":"https://ror.org/047wvvg23"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2022427932","https://openalex.org/W2061896040","https://openalex.org/W2077234767","https://openalex.org/W2096082746","https://openalex.org/W2096942540","https://openalex.org/W2099564498","https://openalex.org/W2105397542","https://openalex.org/W2115139789","https://openalex.org/W2140805857","https://openalex.org/W2157848968"],"related_works":["https://openalex.org/W2134232124","https://openalex.org/W3034438778","https://openalex.org/W4401571341","https://openalex.org/W2044488462","https://openalex.org/W2981877337","https://openalex.org/W3203938600","https://openalex.org/W2169074127","https://openalex.org/W2163707935","https://openalex.org/W83146503","https://openalex.org/W202723009"],"abstract_inverted_index":{"We":[0],"segment":[1],"atherosclerotic":[2],"plaque":[3],"components":[4],"in":[5,52],"in-vivo":[6,41],"MRI":[7],"and":[8,78,95,108,120,137],"CT":[9],"data":[10,42],"using":[11],"supervised":[12],"voxelwise":[13],"classification.":[14],"The":[15],"most":[16],"reliable":[17],"ground":[18,54,106],"truth":[19,55,107],"can":[20],"be":[21],"obtained":[22],"from":[23],"histology":[24],"sections,":[25],"however,":[26],"it":[27],"is":[28,85,130],"not":[29],"straightforward":[30],"to":[31],"use":[32],"this":[33],"for":[34,47,63,91,115,118,122,132],"classifier":[35],"training":[36,48],"as":[37],"the":[38,53,74,81,88,102,105,126],"registration":[39,82],"with":[40],"often":[43],"shows":[44],"misalignments.":[45],"Therefore,":[46],"we":[49],"incorporate":[50],"uncertainty":[51],"via":[56],"\u201dsoft\u201d":[57],"labels":[58,67],"that":[59],"indicate":[60],"a":[61],"probability":[62],"each":[64],"class.":[65],"Soft":[66],"are":[68,113],"created":[69],"by":[70,80],"Gaussian":[71],"blurring":[72],"of":[73],"original":[75],"\u201dhard\u201d":[76],"segmentations,":[77],"weighted":[79],"accuracy.":[83],"Classification":[84],"evaluated":[86],"on":[87],"relative":[89],"volumes":[90],"fibrous,":[92],"lipid-rich":[93],"necrotic":[94,123,138],"calcified":[96],"tissue.":[97,124],"Using":[98,125],"conventional":[99],"hard":[100],"labels,":[101],"differences":[103],"between":[104],"classification":[109],"result":[110],"per":[111],"subject":[112],"-0.4\u00b13.6%":[114],"calcification,":[116],"+7.6\u00b114.9%":[117],"fibrous":[119,135],"-7.2\u00b114.5%":[121],"new":[127],"approach":[128],"accuracy":[129],"improved:":[131],"calcification":[133],"-0.6\u00b11.6%,":[134],"+3.6\u00b116.8%":[136],"tissue":[139],"-2.9\u00b116.1%.":[140]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-17T09:09:15.849793","created_date":"2025-10-10T00:00:00"}
