{"id":"https://openalex.org/W2131602268","doi":"https://doi.org/10.1109/isbi.2011.5872741","title":"Topology preserving automatic segmentation of the spinal cord in magnetic resonance images","display_name":"Topology preserving automatic segmentation of the spinal cord in magnetic resonance images","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2131602268","doi":"https://doi.org/10.1109/isbi.2011.5872741","mag":"2131602268","pmid":"https://pubmed.ncbi.nlm.nih.gov/27293519"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2011.5872741","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4902292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337209","display_name":"Min Chen","orcid":"https://orcid.org/0000-0002-0960-4447"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Chen","raw_affiliation_strings":["Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University; Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke"],"affiliations":[{"raw_affiliation_string":"Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University; Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075622613","display_name":"Aaron Carass","orcid":"https://orcid.org/0000-0003-4939-5085"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802946424","display_name":"Johns Hopkins University Applied Physics Laboratory","ror":"https://ror.org/029pp9z10","country_code":"US","type":"facility","lineage":["https://openalex.org/I145311948","https://openalex.org/I2802946424"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Carass","raw_affiliation_strings":["Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University","institution_ids":["https://openalex.org/I2802946424","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079671980","display_name":"Jennifer L. Cuzzocreo","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Cuzzocreo","raw_affiliation_strings":["The Laboratory of Medical Image Computing, Dept. of Radiology, Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"The Laboratory of Medical Image Computing, Dept. of Radiology, Johns Hopkins University","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052428372","display_name":"Pierre\u2010Louis Bazin","orcid":"https://orcid.org/0000-0002-0141-5510"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre-Louis Bazin","raw_affiliation_strings":["The Laboratory of Medical Image Computing, Dept. of Radiology, Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"The Laboratory of Medical Image Computing, Dept. of Radiology, Johns Hopkins University","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024904743","display_name":"Daniel S. Reich","orcid":"https://orcid.org/0000-0002-2628-4334"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Reich","raw_affiliation_strings":["Dept. of Neurology, Johns Hopkins University; Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke"],"affiliations":[{"raw_affiliation_string":"Dept. of Neurology, Johns Hopkins University; Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066682675","display_name":"Jerry L. Prince","orcid":"https://orcid.org/0000-0002-6553-0876"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802946424","display_name":"Johns Hopkins University Applied Physics Laboratory","ror":"https://ror.org/029pp9z10","country_code":"US","type":"facility","lineage":["https://openalex.org/I145311948","https://openalex.org/I2802946424"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Prince","raw_affiliation_strings":["Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Image Analysis and Communications Laboratory, Dept. of ECE, Johns Hopkins University","institution_ids":["https://openalex.org/I2802946424","https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100337209"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210110767"],"apc_list":null,"apc_paid":null,"fwci":1.5035,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82493141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"1737","last_page":"1740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord","display_name":"Spinal cord","score":0.8426439762115479},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7490180134773254},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6497687101364136},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5178987979888916},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47607865929603577},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4715338349342346},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.46199917793273926},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4409114122390747},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.43636026978492737},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4142676591873169},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4020805060863495},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2668381929397583},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.19183489680290222},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.16283905506134033},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1508495807647705}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.8426439762115479},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7490180134773254},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6497687101364136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5178987979888916},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47607865929603577},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4715338349342346},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.46199917793273926},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4409114122390747},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.43636026978492737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4142676591873169},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4020805060863495},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2668381929397583},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19183489680290222},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16283905506134033},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1508495807647705},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2011.5872741","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmid:27293519","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27293519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4902292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4902292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4902292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4902292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W104325171","https://openalex.org/W127371030","https://openalex.org/W1499038423","https://openalex.org/W1592707575","https://openalex.org/W1966247331","https://openalex.org/W1970557382","https://openalex.org/W1982973387","https://openalex.org/W1988382024","https://openalex.org/W2000439270","https://openalex.org/W2004537679","https://openalex.org/W2012066226","https://openalex.org/W2038390259","https://openalex.org/W2045782417","https://openalex.org/W2053980954","https://openalex.org/W2103275591","https://openalex.org/W2105456967","https://openalex.org/W2108707886","https://openalex.org/W2141619730","https://openalex.org/W2142568997","https://openalex.org/W2156021245","https://openalex.org/W6604211215","https://openalex.org/W6605138295","https://openalex.org/W6629963262","https://openalex.org/W6647383776","https://openalex.org/W6659916107"],"related_works":["https://openalex.org/W2043188193","https://openalex.org/W2001086120","https://openalex.org/W3021493803","https://openalex.org/W2257755506","https://openalex.org/W1975416403","https://openalex.org/W2011111248","https://openalex.org/W2462603952","https://openalex.org/W4256129901","https://openalex.org/W2046365012","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Magnetic":[0],"resonance":[1],"images":[2],"of":[3,26,60,97],"the":[4,35,54,94,98,107],"spinal":[5,19,36,55,99],"cord":[6,20,37,56],"play":[7],"an":[8,42,49],"important":[9],"role":[10],"in":[11],"studying":[12],"neurological":[13],"diseases,":[14],"particularly":[15],"multiple":[16],"sclerosis,":[17],"where":[18],"atrophy":[21],"can":[22,40],"provide":[23],"a":[24,58],"measure":[25],"disease":[27],"progression":[28],"and":[29,44,65],"disability.":[30],"Current":[31],"practices":[32],"involve":[33],"segmenting":[34],"manually,":[38],"which":[39],"be":[41,78],"inconsistent":[43],"time-consuming":[45],"process.":[46],"We":[47],"present":[48],"automatic":[50],"segmentation":[51],"method":[52,74],"for":[53],"using":[57],"combination":[59],"deformable":[61],"atlas":[62],"based":[63],"registration":[64],"topology":[66,96],"preserving":[67],"classification.":[68],"Using":[69],"real":[70],"MR":[71],"data,":[72],"our":[73,90],"is":[75],"shown":[76],"to":[77,83],"highly":[79],"accurate":[80],"when":[81],"compared":[82],"segmentations":[84,103],"by":[85],"manual":[86],"raters.":[87],"In":[88],"addition,":[89],"results":[91],"always":[92],"maintain":[93],"correct":[95],"cord,":[100],"therefore":[101],"providing":[102],"more":[104],"consistent":[105],"with":[106],"known":[108],"anatomy.":[109]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}