{"id":"https://openalex.org/W2130256569","doi":"https://doi.org/10.1109/isbi.2011.5872734","title":"Methods and algorithms for extracting high-content signatures from cells, tissues, and model organisms","display_name":"Methods and algorithms for extracting high-content signatures from cells, tissues, and model organisms","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2130256569","doi":"https://doi.org/10.1109/isbi.2011.5872734","mag":"2130256569"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2011.5872734","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872734","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027416348","display_name":"Jens Rittscher","orcid":"https://orcid.org/0000-0002-8528-8298"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Rittscher","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066313021","display_name":"Dirk Padfield","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Padfield","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027834984","display_name":"Agust\u00edn Santamar\u00eda","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Santamaria","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113698223","display_name":"J. Tu","orcid":"https://orcid.org/0000-0002-9610-9531"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Tu","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102966437","display_name":"Ali Can","orcid":"https://orcid.org/0000-0001-9374-0726"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Can","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228361","display_name":"Musodiq Bello","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Bello","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048360771","display_name":"David Yang Gao","orcid":"https://orcid.org/0000-0002-2245-8050"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Gao","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003948628","display_name":"Anup Sood","orcid":"https://orcid.org/0000-0001-7768-0209"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Sood","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109073611","display_name":"Michael Gerdes","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gerdes","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081260142","display_name":"Fiona Ginty","orcid":"https://orcid.org/0000-0001-6638-683X"},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Ginty","raw_affiliation_strings":["GE Global Research Center, Niskayuna, NY, USA","GE Global Research,Niskayuna,NY,USA"],"affiliations":[{"raw_affiliation_string":"GE Global Research Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]},{"raw_affiliation_string":"GE Global Research,Niskayuna,NY,USA","institution_ids":["https://openalex.org/I4210134512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5027416348"],"corresponding_institution_ids":["https://openalex.org/I4210134512"],"apc_list":null,"apc_paid":null,"fwci":0.7132,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82072424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":null,"first_page":"1712","last_page":"1716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9605000019073486,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6884673833847046},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6754049062728882},{"id":"https://openalex.org/keywords/zebrafish","display_name":"Zebrafish","score":0.6236379146575928},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.5362118482589722},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5175649523735046},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.4960578382015228},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44167348742485046},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4153246581554413},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20738723874092102},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20215937495231628}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6884673833847046},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6754049062728882},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6236379146575928},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.5362118482589722},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5175649523735046},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4960578382015228},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44167348742485046},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4153246581554413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20738723874092102},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20215937495231628},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2011.5872734","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872734","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:c617d605-2507-4157-89d8-9505aa23b4da","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:c617d605-2507-4157-89d8-9505aa23b4da","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320309549","display_name":"University of Houston","ror":"https://ror.org/040vwpm13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1538747122","https://openalex.org/W1556323253","https://openalex.org/W2002089932","https://openalex.org/W2004164430","https://openalex.org/W2066130773","https://openalex.org/W2118255421","https://openalex.org/W2133487501","https://openalex.org/W2137788460","https://openalex.org/W2154917588","https://openalex.org/W2157603905","https://openalex.org/W2158787692","https://openalex.org/W2341512478","https://openalex.org/W6650874451"],"related_works":["https://openalex.org/W2464195423","https://openalex.org/W4304191862","https://openalex.org/W3092406308","https://openalex.org/W3034751833","https://openalex.org/W2021094532","https://openalex.org/W2884937845","https://openalex.org/W2274888953","https://openalex.org/W4313700805","https://openalex.org/W2013003323","https://openalex.org/W1865162173"],"abstract_inverted_index":{"While":[0],"high-content":[1],"screening":[2],"is":[3],"already":[4],"playing":[5],"an":[6],"important":[7],"role":[8],"in":[9],"drug":[10],"discovery,":[11],"a":[12,24],"growing":[13],"number":[14],"of":[15,27,62,79],"academic":[16],"laboratories":[17],"are":[18,39],"applying":[19],"these":[20],"techniques":[21],"to":[22],"conduct":[23],"system-level":[25],"analysis":[26,78],"biological":[28],"processes.":[29],"In":[30],"this":[31],"context":[32],"more":[33],"complex":[34,81],"assays":[35],"and":[36,50,64],"model":[37,52],"systems":[38],"being":[40],"imaged":[41],"at":[42,70],"higher":[43],"throughput.":[44],"Examples":[45],"include":[46],"co-culture":[47],"assays,":[48],"tissues,":[49],"entire":[51],"systems,":[53],"as":[54],"for":[55],"example":[56],"zebrafish.":[57],"This":[58],"summary":[59],"presents":[60],"examples":[61],"methods":[63],"algorithms":[65],"that":[66,74],"have":[67],"been":[68],"developed":[69],"GE":[71],"Global":[72],"Research":[73],"facilitate":[75],"the":[76],"quantitative":[77],"such":[80],"specimens.":[82]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
