{"id":"https://openalex.org/W2126846422","doi":"https://doi.org/10.1109/isbi.2011.5872492","title":"Automatic batch-invariant color segmentation of histological cancer images","display_name":"Automatic batch-invariant color segmentation of histological cancer images","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2126846422","doi":"https://doi.org/10.1109/isbi.2011.5872492","mag":"2126846422","pmid":"https://pubmed.ncbi.nlm.nih.gov/27532016"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2011.5872492","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111775666","display_name":"Sonal Kothari","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonal Kothari","raw_affiliation_strings":["Electrical and Computer Engineering, Georgia Institute of Technology","Electrical and Computer Engineering, Georgia Institute of Technology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Electrical and Computer Engineering, Georgia Institute of Technology, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074230084","display_name":"John H. Phan","orcid":"https://orcid.org/0000-0002-4670-2660"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Phan","raw_affiliation_strings":["Biomedical Engineering, Georgia Institute of Technology and Emory University","Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022550153","display_name":"Richard A. Moffitt","orcid":"https://orcid.org/0000-0003-2723-5902"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Moffitt","raw_affiliation_strings":["Biomedical Engineering, Georgia Institute of Technology and Emory University","Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103552975","display_name":"Todd H. Stokes","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd H. Stokes","raw_affiliation_strings":["Biomedical Engineering, Georgia Institute of Technology and Emory University","Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044961469","display_name":"Shelby E. Hassberger","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelby E. Hassberger","raw_affiliation_strings":["Biomedical Engineering, Georgia Institute of Technology and Emory University","Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050484420","display_name":"Qaiser Chaudry","orcid":"https://orcid.org/0000-0002-8844-1120"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qaiser Chaudry","raw_affiliation_strings":["Electrical and Computer Engineering, Georgia Institute of Technology","Electrical and Computer Engineering, Georgia Institute of Technology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Electrical and Computer Engineering, Georgia Institute of Technology, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112081743","display_name":"Andrew N. Young","orcid":null},"institutions":[{"id":"https://openalex.org/I1305001552","display_name":"Grady Memorial Hospital","ror":"https://ror.org/009hj8759","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1305001552","https://openalex.org/I4210092882"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210092882","display_name":"Grady Health System","ror":"https://ror.org/00k1xr956","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210092882"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew N. Young","raw_affiliation_strings":["Pathology and Laboratory Medicine, Emory University; Grady Health System, Atlanta, GA","Pathology and Laboratory Medicine, Emory University, USA","Grady Health System, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University; Grady Health System, Atlanta, GA","institution_ids":["https://openalex.org/I4210092882","https://openalex.org/I1305001552"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Grady Health System, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210092882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030096887","display_name":"May D. Wang","orcid":"https://orcid.org/0000-0003-3961-3608"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May D. Wang","raw_affiliation_strings":["Biomedical Engineering, Georgia Institute of Technology and Emory University","Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3533,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.97537514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"2011","issue":null,"first_page":"657","last_page":"660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6633642315864563},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6151447296142578},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.6006747484207153},{"id":"https://openalex.org/keywords/invariant","display_name":"Invariant (physics)","score":0.5786741971969604},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5532391667366028},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.547726571559906},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3612039089202881},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24246636033058167}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6633642315864563},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6151447296142578},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.6006747484207153},{"id":"https://openalex.org/C190470478","wikidata":"https://www.wikidata.org/wiki/Q2370229","display_name":"Invariant (physics)","level":2,"score":0.5786741971969604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5532391667366028},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.547726571559906},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3612039089202881},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24246636033058167},{"id":"https://openalex.org/C37914503","wikidata":"https://www.wikidata.org/wiki/Q156495","display_name":"Mathematical physics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2011.5872492","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmid:27532016","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27532016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:3945116","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2060203799","https://openalex.org/W2101061221","https://openalex.org/W2110059894","https://openalex.org/W2132162500","https://openalex.org/W2141690231","https://openalex.org/W2156398782","https://openalex.org/W2159551006","https://openalex.org/W3209544266","https://openalex.org/W6803239612"],"related_works":["https://openalex.org/W4379231730","https://openalex.org/W4389858081","https://openalex.org/W2501551404","https://openalex.org/W4298131179","https://openalex.org/W2113201962","https://openalex.org/W4385583601","https://openalex.org/W4395685956","https://openalex.org/W3159516372","https://openalex.org/W4398146871","https://openalex.org/W1522196789"],"abstract_inverted_index":{"We":[0,104],"propose":[1],"an":[2,30,129],"automatic":[3],"color":[4,49,57,102],"segmentation":[5,16,28,50,95,131],"system":[6,75,91,107,120],"that":[7],"(1)":[8],"incorporates":[9],"domain":[10,42],"knowledge":[11,77],"to":[12,21,24,46,82,118],"guide":[13],"histological":[14],"image":[15],"and":[17,69,84],"(2)":[18],"normalizes":[19],"images":[20,81,114],"reduce":[22],"sensitivity":[23],"batch":[25],"effects.":[26],"Color":[27],"is":[29],"important,":[31],"yet":[32],"difficult,":[33],"component":[34],"of":[35,55,71,111,133],"image-based":[36],"diagnostic":[37,72],"systems.":[38,73],"User-interactive":[39],"guidance":[40,64],"by":[41,96],"experts-i.e.,":[43],"pathologists-often":[44],"leads":[45],"the":[47,66,94,100],"best":[48],"or":[51],"\u201cground":[52],"truth\u201d":[53],"regardless":[54],"stain":[56],"variations":[58],"in":[59,87,99,116],"different":[60],"batches.":[61],"However,":[62],"such":[63],"limits":[65],"objectivity,":[67],"reproducibility":[68],"speed":[70],"Our":[74],"uses":[76],"from":[78],"pre-segmented":[79],"reference":[80],"normalize":[83],"classify":[85],"pixels":[86,98],"patient":[88],"images.":[89],"The":[90],"then":[92],"refines":[93],"re-classifying":[97],"original":[101],"space.":[103],"test":[105],"our":[106],"on":[108],"four":[109],"batches":[110],"H&E":[112],"stained":[113],"and,":[115],"comparison":[117],"a":[119],"with":[121],"no":[122],"normalization":[123],"(39%":[124],"average":[125,130],"accuracy),":[126],"we":[127],"obtain":[128],"accuracy":[132],"85%.":[134]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
